Results 111 to 120 of about 93,358 (167)

Correlation of A3A expression with APOBEC-induced mutations in multiple cancer types.

, 2019
RSEM normalized RNA-seq values for A3A (blue) and A3B (red) were obtained for 410 bladder (BLCA), 197 cervical (CESC), and 549 head and neck (HNSC) cancers assessed by the Cancer Genome Atlas.
Christopher D. Collins (2959212), Debra Mitchell (8129844), Amber L. Brown (8129838), Luis M. Cortez (8129835), Alexander J. Brown (6018602), Madeline A. Dennis (8129841), Tony M. Mertz (8129847), Steven A. Roberts (8129850)   +7 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Spatial patterns of APOBEC mutagenesis in the tumour microenvironment of Asian breast cancer

Abstract A germline deletion of the coding region at the APOBEC3B ( A3B ) gene that is common in Asian and Oceanic populations has been found to be correlated with increased APOBEC mutagenesis, immune activation, and tumour heterogeneity in breast
Zi Ching Tan, Yang Wu, Zhen Wei Neo, Mai Chan Lau, Soo-Hwang Teo, Joe Poh Sheng Yeong, Siow-Wee Chang, Jia Wern Pan   +7 more
openaire   +1 more source

Acquisition of APOBEC Mutagenesis and Microsatellite Instability Signatures in the Development of Brain Metastases in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma. [PDF]

JCO Precis Oncol, 2020
Dessources K, Da Cruz Paula A, Pareja F, Stylianou A, Cybulska P, Farmanbar A, Chandarlapaty S, Abu-Rustum NR, Reis-Filho JS, Weigelt B, Mueller JJ.   +10 more
europepmc   +1 more source

Molecular patterns and mechanisms of tumorigenesis in HPV-associated and HPV-independent sinonasal squamous cell carcinoma

Nature Communications
Mechanisms of tumorigenesis in sinonasal squamous cell carcinoma (SNSCC) remain poorly understood due to its rarity. A subset of SNSCC is associated with human papillomavirus (HPV), but it is unclear whether HPV drives tumorigenesis or acts as a neutral ...
Fernando T. Zamuner, Sreenivasulu Gunti, Gabriel J. Starrett, Farhoud Faraji, Tiffany Toni, Anirudh Saraswathula, Kenny Vu, Anuj Gupta, Yan Zhang, Daniel L. Faden, Michael E. Bryan, Theresa Guo, Nicholas R. Rowan, Murugappan Ramanathan, Andrew P. Lane, Carole Fakhry, Gary L. Gallia, Clint T. Allen, Lisa M. Rooper, Nyall R. London   +19 more
doaj   +1 more source

The genomic landscape of Vk*MYC myeloma highlights shared pathways of transformation between mice and humans

Nature Communications
Multiple myeloma (MM) is a heterogeneous disease characterized by frequent MYC translocations. Sporadic MYC activation in the germinal center of genetically engineered Vk*MYC mice is sufficient to induce plasma cell tumors in which a variety of secondary
Francesco Maura, David G. Coffey, Caleb K. Stein, Esteban Braggio, Bachisio Ziccheddu, Meaghen E. Sharik, Megan T. Du, Yuliza Tafoya Alvarado, Chang-Xin Shi, Yuan Xiao Zhu, Erin W. Meermeier, Gareth J. Morgan, Ola Landgren, P. Leif Bergsagel, Marta Chesi   +14 more
doaj   +1 more source

The Use of Mutational Signatures to Decipher the Inter-Relationship of Reactive Oxygen Species with Homologous Recombination and Non-Homologous End-Joining Deficiencies as Well as Their Effects on APOBEC Mutagenesis in Breast Cancer. [PDF]

Cancers (Basel)
Farmanbar A, Kneller R, Firouzi S.
europepmc   +1 more source

Intratumoral Mycobacterium abscessus promotes cytidine deaminase mutagenesis in non-small cell lung cancer. [PDF]

Signal Transduct Target Ther
Li X, Li MT, Ou KP, Gao PQ, Xiao AH, Yang J, Li JN, Deng WY, Bie MJ, Huang AL, Shi XF, Long QX.   +11 more
europepmc   +1 more source

Motif-centered analyses reveal universal and tissue-specific mutagenic mechanisms operating in the human body. [PDF]

NAR Cancer
Sauty SM, Hsiao YC, Klimczak LJ, Gordenin DA.   +3 more
europepmc   +1 more source

Genomic Features Do Not Account for Differences in Multiple Myeloma Risk by Ancestry. [PDF]

Blood Cancer Discov
Maclachlan KH, Papadimitriou M, Blaney P, Baughn LB, Shekarkhand T, Poos AM, Ziccheddu B, Tang H, Yan H, Diamond B, Zhang Y, Cimera R, Dogan A, Gagler D, Boyle E, Hultcrantz M, Mailankody S, Hassoun H, Shah UA, Tan C, Brown EE, Winterkorn L, Chu T, Steinsnyder Z, Vaksman Z, Davies FE, Korde N, Landgren O, Raab MS, Lesokhin AM, Robine N, Weinhold N, Usmani SZ, Maura F, Morgan GJ.   +34 more
europepmc   +1 more source