Results 101 to 110 of about 93,358 (167)

Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma

The EMBO Journal
Two APOBEC DNA cytosine deaminase enzymes, APOBEC3A and APOBEC3B, generate somatic mutations in cancer, thereby driving tumour development and drug resistance.
Nicola J Smith, Ian Reddin, Paige Policelli, Sunwoo Oh, Nur Zainal, Emma Howes, Benjamin Jenkins, Ian Tracy, Mark Edmond, Benjamin Sharpe, Damian Amendra, Ke Zheng, Nagayasu Egawa, John Doorbar, Anjali Rao, Sangeetha Mahadevan, Michael A Carpenter, Reuben S Harris, Simak Ali, Christopher Hanley, Rémi Buisson, Emma King, Gareth J Thomas, Tim R Fenton   +23 more
doaj   +1 more source

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity

, 2018
Elucidation of the proteogenomic evolution of metastatic tumors may offer insight into the poor prognosis of patients harboring metastatic disease. We performed whole-exome and transcriptome sequencing, copy number alterations (CNA) and mass spectrometry-
Ludmila Prokunina-Olsson, Udayan Guha, Anna R. Panchenko, Sivasish Sindiri, Stephen Hewitt, Tapan K. Maity, Xu Zhang, Shaojian Gao, David Kleiner, Constance M. Cultraro, Alexandr Goncearenco, Anish Thomas, Arun Rajan, Corey A. Carter, Nitin Roper, A. Rouf Banday, Abhilash Venugopalan, Rajesh Patidar, Romi Biswas, Javed Khan   +19 more
core   +1 more source

UV- and MMS-induced mutagenesis of lambdaO(am)8 phage under nonpermissive conditions for phage DNA replication. [PDF]

, 2003
Mutagenesis in Escherichia coli, a subject of many years of study is considered to be related to DNA replication. DNA lesions nonrepaired by the error-free nucleotide excision repair (NER), base excision repair (BER) and recombination repair (RR), stop ...
Felczak, Magdalena, Krwawicz, Joanna, Pietrzykowska, Irena, Czajkowska, Anna   +3 more
core   +1 more source

Differential effects on tumor progression by APOBEC3A, APOBEC3B, and APOBEC3H Haplotype I in a breast cancer mouse xenograft model

Frontiers in Genetics
IntroductionThe APOBEC3 family of cytidine deaminases induces somatic mutations that are highly prevalent in cancers, but the functional consequences remain largely unknown.MethodsTo determine these consequences, we exposed MCF7 tumorigenic breast ...
Milaid Granadillo Rodríguez, Lai Wong, Arzhang Shayeganmehr, Diogo Pellegrina, Frederick S. Vizeacoumar, Franco J. Vizeacoumar, Franco J. Vizeacoumar, Mohamed Helmy, Mohamed Helmy, Mohamed Helmy, Linda Chelico   +10 more
doaj   +1 more source

Comprehensive Analyses Reveal Effects on Tumor Immune Infiltration and Immunotherapy Response of APOBEC Mutagenesis and Its Molecular Mechanisms in Esophageal Squamous Cell Carcinoma. [PDF]

Int J Biol Sci, 2023
Yang J, Xiang T, Zhu S, Lao Y, Wang Y, Liu T, Li K, Ma Y, Zhong C, Zhang S, Tan W, Lin D, Wu C.   +12 more
europepmc   +1 more source

APOBEC Mutagenesis and DNA (Mis)Repair [PDF]

, 2019
University of Minnesota Ph.D. dissertation. August 2019. Major: Pharmacology. Advisors: Reuben Harris, Hiroshi Hiasa. 1 computer file (PDF); viii, 126 pages.Cancer imposes a burden on the entire world. As of 2019, cancer accounts for 1 in every 6 deaths
Serebrenik, Artur
core  

Apobec-mediated retroviral hypermutation in vivo is dependent on mouse strain.

PLoS Pathogens
Replication of the complex retrovirus mouse mammary tumor virus (MMTV) is antagonized by murine Apobec3 (mA3), a member of the Apobec family of cytidine deaminases.
Hyewon Byun, Gurvani B Singh, Wendy Kaichun Xu, Poulami Das, Alejandro Reyes, Anna Battenhouse, Dennis C Wylie, Mario L Santiago, Mary M Lozano, Jaquelin P Dudley   +9 more
doaj   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source

APOBEC-induced mutations in human cancers are strongly enriched on the lagging DNA strand during replication

, 2016
APOBEC3A and APOBEC3B, cytidine deaminases of the APOBEC family, are among the main factors causing mutations in human cancers. APOBEC deaminates cytosines in single-stranded DNA (ssDNA).
Soldatov, Ruslan A, Seplyarskiy, Vladimir B, Popadin, Konstantin, Nikolaev, Sergey Igorievich, Ruslan A. Soldatov, Antonarakis, Stylianos, Vladimir B. Seplyarskiy, Konstantin Y. Popadin, Stylianos E. Antonarakis, Sergey I. Nikolaev, Georgii A. Bazykin, Bazykin, Georgii A   +11 more
core   +1 more source

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

PLoS Biology, 2019
Redox stress is a major hallmark of cancer. Analysis of thousands of sequenced cancer exomes and whole genomes revealed distinct mutational signatures that can be attributed to specific sources of DNA lesions.
Natalya P Degtyareva, Natalie Saini, Joan F Sterling, Victoria C Placentra, Leszek J Klimczak, Dmitry A Gordenin, Paul W Doetsch   +6 more
doaj   +1 more source