Results 81 to 90 of about 93,358 (167)

Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma

Nature Communications, 2023
A variety of mutational processes drive cancer development, but their dynamics across the entire disease spectrum from pre-cancerous to advanced neoplasia are poorly understood.
Sujath Abbas, Oriol Pich, Ginny Devonshire, Shahriar A. Zamani, Annalise Katz-Summercorn, Sarah Killcoyne, Calvin Cheah, Barbara Nutzinger, Nicola Grehan, Nuria Lopez-Bigas, OCCAMS Consortium, Rebecca C. Fitzgerald, Maria Secrier   +12 more
doaj   +1 more source

Clonal hematopoiesis in patients with cancer and cancer survivors: From clonal burden to cardiovascular diseases

Cancer, Volume 132, Issue 10, 15 May 2026.
ABSTRACT Over the past decade, clonal hematopoiesis (CH) has gained substantial attention as a prevalent, age‐associated phenomenon with major implications for hematologic malignancy, cardiovascular disease, and mortality. CH arises from the clonal expansion of hematopoietic stem cells and progenitor cells harboring somatic mutations, most commonly in ...
Christian H. Nenninger, Keith Anderson, Jenaro Espitia‐Corredor, Brittany Echevarria, Vertica Agnihotri, Zhao Wang, Scott R. Goldsmith, June‐Wha Rhee   +7 more
wiley   +1 more source

Genomic characterization of tumor mutational burden-high breast carcinomas

npj Precision Oncology
Tumor mutational burden (TMB) has emerged as a potential surrogate for neoantigen load and an indicator of immune checkpoint (IC)-blockade response; however, its precise significance in breast cancer (BC) is not fully understood. Here, we comprehensively
Theodore Vougiouklakis, Chad Vanderbilt, Satshil Rana, Abhinita Mohanty, Fresia Pareja, Edi Brogi, Christopher Schwartz, Maria E. Arcila, Marc Ladanyi, Hanna Y. Wen, Dara S. Ross   +10 more
doaj   +1 more source

Predictive modelling of response to neoadjuvant therapy in HER2+ breast cancer

npj Breast Cancer, 2023
HER2-positive (HER2+) breast cancer accounts for 20–25% of all breast cancers. Predictive biomarkers of neoadjuvant therapy response are needed to better identify patients with early stage disease who may benefit from tailored treatments in the adjuvant ...
Nicola Cosgrove, Alex J. Eustace, Peter O’Donovan, Stephen F. Madden, Bruce Moran, John Crown, Brian Moulton, Patrick G. Morris, Liam Grogan, Oscar Breathnach, Colm Power, Michael Allen, Janice M. Walshe, Arnold D. Hill, Anna Blümel, Darren O’Connor, Sudipto Das, Małgorzata Milewska, Joanna Fay, Elaine Kay, Sinead Toomey, Bryan T. Hennessy, Simon J. Furney   +22 more
doaj   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, Volume 13, Issue 20, 9 April 2026.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis

ABSTRACT Mutations in somatic cells are inflicted by both extrinsic and intrinsic sources and contribute over time to cancer. Tobacco smoke contains chemical carcinogens that have been causatively implicated with cancers of the lung and head & neck 1,2 .
Cameron Durfee, Erik N. Bergstrom, Marcos Díaz-Gay, Yufan Zhou, Nuri Alpay Temiz, Mahmoud A. Ibrahim, Shuvro P. Nandi, Yaxi Wang, Xingyu Liu, Christopher D. Steele, Joshua Proehl, Rachel I. Vogel, Prokopios P. Argyris, Ludmil B. Alexandrov, Reuben S. Harris   +14 more
openaire   +3 more sources

EBV Genome Variations and Association With Diseases

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT The Epstein‐Barr virus (EBV) is associated with a range of diseases, including malignancies and autoimmune disorders. Driven by advances in deep sequencing technologies, recent studies have systematically characterized EBV genomic landscapes in diverse clinical specimens, uncovering distinct geographic patterns in strain distribution. However,
Xueer Lin, Jingtong Liang, Qiuting Zhang, Qinyao Huang, Xinyu Zhang, Miao Xu   +5 more
wiley   +1 more source

A PRESPECTIVE STUDY ON APOBEC PROTEIN FAMILY [PDF]

, 2019
Apobec is an apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like" is a family of deaminases. It has two types of APOBEC enzymes n-terminal of apobec enzyme and C-terminal of APOBEC enzyme.
KOMAL, S., GEJALAKSHMI, S., HARIKRISHNAN, N.   +2 more
core   +1 more source

When R‐Loops Go Awry: Genome Instability and Neurological Diseases

European Journal of Neuroscience, Volume 63, Issue 8, April 2026.
DNA normally exists as a double helix formed by two complementary strands. During gene transcription, however, one strand of DNA can bind to RNA, causing the other DNA strand to be displaced. This creates a structure called an R‐loop. R‐loops play important roles in normal cellular processes such as gene expression, DNA replication, and transcription ...
Nur Rasyiqin Rasli, Yu Katsuyama
wiley   +1 more source

Recombination Is Responsible for the Increased Recovery of Drug-Resistant Mutants with Hypermutated Genomes in Resting Yeast Diploids Expressing APOBEC Deaminases

Frontiers in Genetics, 2017
DNA editing deaminases (APOBECs) are implicated in generation of mutations in somatic cells during tumorigenesis. APOBEC-dependent mutagenesis is thought to occur during transient exposure of unprotected single-stranded DNA. Mutations frequently occur in
Artem G. Lada, Artem G. Lada, Elena I. Stepchenkova, Elena I. Stepchenkova, Elena I. Stepchenkova, Anna S. Zhuk, Anna S. Zhuk, Sergei F. Kliver, Igor B. Rogozin, Igor B. Rogozin, Dmitrii E. Polev, Alok Dhar, Youri I. Pavlov, Youri I. Pavlov, Youri I. Pavlov, Youri I. Pavlov   +15 more
doaj   +1 more source