Results 71 to 80 of about 93,358 (167)

The dark side of DNA repair

eLife, 2014
The BER pathway is widely used to repair DNA damage in cells, but it can also introduce unwanted mutations and is sometimes hijacked by other pathways.
Samuel H Wilson
doaj   +1 more source

High‐density mutation tracks are associated with proton‐beam irradiation patterns in Sorghum bicolor

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract Induced mutagenesis is a cornerstone of crop functional genomics, yet the extent to which distinct radiation sources reshape the spatial distribution of mutations remains difficult to evaluate in reduced‐representation datasets. Here, we analyze a published genotyping‐by‐sequencing (GBS) panel (192,040 loci) to compare proton‐beam and gamma ...
Ezekiel Ahn, Insuck Baek, Seunghyun Lim, Louis K. Prom, Moon S. Kim, Lyndel W. Meinhardt, Clint Magill   +6 more
wiley   +1 more source

APOBEC and Cancer Viroimmunotherapy: Thinking the Unthinkable

, 2021
The apolipoprotein B mRNA editing enzyme catalytic polypeptide (APOBEC) family protects against infection by degrading incoming viral genomes through cytosine deamination.
Richard G. Vile, Hardev Pandha, Harrington, KJ, Pulido, JS, Vile, RG, Pandha, H, Melcher, A, Kevin J. Harrington, Alan Melcher, Jose S. Pulido   +9 more
core   +1 more source

Deep learning model accurately classifies metastatic tumors from primary tumors based on mutational signatures

Scientific Reports, 2023
Metastatic propagation is the leading cause of death for most cancers. Prediction and elucidation of metastatic process is crucial for the treatment of cancer.
Weisheng Zheng, Mengchen Pu, Xiaorong Li, Zhaolan Du, Sutong Jin, Xingshuai Li, Jielong Zhou, Yingsheng Zhang   +7 more
doaj   +1 more source

The chromatin network helps prevent cancer-associated mutagenesis at transcription-replication conflicts

Nature Communications, 2023
Genome instability is a feature of cancer cells, transcription being an important source of DNA damage. This is in large part associated with R-loops, which hamper replication, especially at head-on transcription-replication conflicts (TRCs).
Aleix Bayona-Feliu, Emilia Herrera-Moyano, Nibal Badra-Fajardo, Iván Galván-Femenía, María Eugenia Soler-Oliva, Andrés Aguilera   +5 more
doaj   +1 more source

SDM-assist software to design site-directed mutagenesis primers introducing "silent" restriction sites [PDF]

, 2013
BACKGROUND:Over the past decades site-directed mutagenesis (SDM) has become an indispensable tool for biological structure-function studies. In principle, SDM uses modified primer pairs in a PCR reaction to introduce a mutation in a cDNA insert.
Karnik, Abhijit, Grefen, Christopher, Karnik, Rucha   +2 more
core   +4 more sources

Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy

MedComm, Volume 7, Issue 7, July 2026.
Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu, Zhixing Hao, Lili Li, Huiying Liu, Chenghui Yang, Zhen Wang   +5 more
wiley   +1 more source

Lamin B1 safeguards the B cell genome and shapes lymphoma outcome

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Lamin B1 is a structural component of the nuclear lamina that participates in genome organization and transcriptional control. During adaptive immune responses, B lymphocytes in germinal centers (GCs) undergo clonal expansion and programmed DNA damage at immunoglobulin loci, while simultaneously downregulating Lamin B1.
Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko   +12 more
wiley   +1 more source

APOBEC3 SNPs Predict APOBEC Mutagenesis and Cancer Risk [PDF]

Cancer Discovery, 2016
Abstract SNPs in APOBEC3 alter expression of APOBEC3A/APOBEC3B to affect somatic APOBEC-signature mutations.
openaire   +1 more source

APOBEC3B, a molecular driver of mutagenesis in human cancers

Cell & Bioscience, 2017
Human cancers results in large part from the accumulation of multiple mutations. The progression of premalignant cells is an evolutionary process in which mutations provide the fundamental driving force for genetic diversity.
Jun Zou, Chen Wang, Xiangyi Ma, Edward Wang, Guang Peng   +4 more
doaj   +1 more source