Results 61 to 70 of about 93,358 (167)

MicroRNAs regulate APOBEC gene expression [PDF]

, 2018
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) is a family of evolutionarily conserved cytidine deaminases, encoded by eleven genes located in the human genome.
Cao, Wei, Wu, Wei
core   +1 more source

Within-Host Variations of Human Papillomavirus Reveal APOBEC Signature Mutagenesis in the Viral Genome [PDF]

Journal of Virology, 2018
ABSTRACT Persistent infection with oncogenic human papillomaviruses (HPVs) causes cervical cancer, accompanied by the accumulation of somatic mutations into the host genome. There are concomitant genetic changes in the HPV genome during viral infection; however, their relevance to cervical carcinogenesis is poorly understood ...
Yusuke, Hirose, Mamiko, Onuki, Yuri, Tenjimbayashi, Seiichiro, Mori, Yoshiyuki, Ishii, Takamasa, Takeuchi, Nobutaka, Tasaka, Toyomi, Satoh, Tohru, Morisada, Takashi, Iwata, Shingo, Miyamoto, Koji, Matsumoto, Akihiko, Sekizawa, Iwao, Kukimoto   +13 more
openaire   +2 more sources

APOBEC Mutagenesis as a Driver of Tumor Evolution through Genetic Heterogeneity and Immunogenicity

, 2021
The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family of cytidine deaminases is one of the most common endogenous sources of single base substitution mutations in human cancer.
DiMarco, Ashley
core   +1 more source

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

Cancer Science, EarlyView.
UV irradiation induces two major types of pyrimidine dimers, CPDs and 6–4PPs. Whereas 6–4PPs efficiently induce cell‐cycle arrest, CPDs do not and frequently persist into S phase. As a result, DSBs can arise in the presence of unrepaired CPDs after 6–4PPs have been repaired, increasing the risk of genomic instability.
Ken‐ichi Yoshioka, Yusuke Matsuno, Rika Kusumoto‐Matsuo   +2 more
wiley   +1 more source

APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response

, 2017
BackgroundThe APOBEC family of enzymes is responsible for a mutation signature characterized by a TCW>T/G mutation. APOBEC-mediated mutagenesis is implicated in a wide variety of tumors, including bladder cancer.
Kalen J. Rimar, Joshua J. Meeks, Damiano Fantini, Alexander P. Glaser   +3 more
core   +1 more source

Cumulative Antigen Suppression Reduces Clonal Plasma Cell Evolution in Gaucher Disease

American Journal of Hematology, Volume 101, Issue 9, Page 2197-2213, September 2026.
ABSTRACT Chronic antigenic stimulation is implicated in the pathogenesis of monoclonal gammopathy and multiple myeloma, yet longitudinal human evidence linking sustained antigen exposure to modifiable clonal plasma cell evolution remains limited. Gaucher disease (GD), caused by biallelic GBA1 pathogenic variants, is characterized by accumulation of ...
Noor Ul Ain, Noffar Bar, Lilu Guo, Katherine Klinger, Punita Gupta, Atta Ur Rahman, Ruhua Yang, Yanhong Deng, Natalia Neparidze, Shiny Nair, Pramod K. Mistry   +10 more
wiley   +1 more source

Analysis of somatic mutations and key driving factors of cervical cancer progression

Open Medicine, 2023
We investigated the somatic mutations and key driving factors of cervical cancer by whole exome sequencing . We found 22,183 somatic single nucleotide variations (SNVs) in 52 paired samples.
Niyazi Mayinuer, Han Lili, Husaiyin Sulaiya, Aishanjiang Ayimila, Guo Min, Muhaimati Gulibanu, Rozi Hankez, Sun Haiyan, Lu Jing, Ma Chunhua, Rouzi Nuermangul, Liu Xiaowan, Zhu Kaichun   +12 more
doaj   +1 more source

STK11 Mutations and Deletions Define an Aggressive Molecular Subgroup of Cervical Adenocarcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
STK11 alterations, including mutations, focal deletions, and structural disruption of chromosome 19p, define a distinct molecular subgroup of cervical adenocarcinoma associated with younger age at diagnosis, poorer survival, and reduced benefit from immune checkpoint inhibitors, supporting improved molecular classification and future precision ...
Emma W. Robinson, Elisabeth A. Murphy, Anaseidy Albanez, Sonam Tulsyan, Hong Lou, Yi Xie, Weiyin Zhou, Qian Yang, Tawnjerae Joe, Tongwu Zhang, Jia Liu, Wen Luo, Dongjing Wu, Herbert Higson, Mathias Viard, Mary Carrington, Matthew Oberley, Hesler Morales, Lisa Mirabello, Enrique Alvirez, Roberto Orozco, Eduardo Gharzouzi, Michael Dean   +22 more
wiley   +1 more source

APOBEC3-mediated mutagenesis in cancer: causes, clinical significance and therapeutic potential

Journal of Hematology & Oncology, 2023
Apolipoprotein B mRNA-editing enzyme, catalytic polypeptides (APOBECs) are cytosine deaminases involved in innate and adaptive immunity. However, some APOBEC family members can also deaminate host genomes to generate oncogenic mutations.
Kelly Butler, A. Rouf Banday
doaj   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, Volume 3, Issue 3, September 2026.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source