Results 91 to 100 of about 93,358 (167)

Advances in CRISPR Base Editing: From Molecular Evolution to Therapeutic Applications in Genomic Medicine

Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.
ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan, Ezgi Erbasan, Fulya Erendor, Salih Sanlioglu   +3 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, Volume 20, Issue 3, Page 709-726, March 2026.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Genomic and Transcriptomic Landscape of Hyper-Apobec Multiple Myeloma

, 2023
Introduction APOBEC mutational signatures are one of the most important mutational signatures in newly diagnosed multiple myeloma (NDMM). APOBEC mutagenesis primarily works through two enzymes, APOBEC3A (A3A) and APOBEC3B (A3B).
Papadimitriou, Marios, Meads, Mark B, Weinhold, Niels, Usmani, Saad Z, Landgren, Ola, Ziccheddu, Bachisio, Maura, Francesco, Poos, Alexandra Maria, Raab, Marc S., Maclachlan, Kylee H, Morgan, Gareth J., Tauro, Marilena, Landgren, Carl, Alaoui, Abdessamad Youssfi, Shain, Kenneth H.   +14 more
core   +1 more source

Interplay between RNA‐protein interactions and RNA structures in gene regulation

FEBS Open Bio, Volume 16, Issue 2, Page 299-313, February 2026.
Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko, Mauro Scaravilli, Minna‐Liisa Änkö   +2 more
wiley   +1 more source

HPV meets APOBEC: New players in head and neck cancer [*Biolatti M, Dell'Oste V* co-last authors].

, 2021
Besides smoking and alcohol, human papillomavirus (HPV) is a factor promoting head and neck squamous cell carcinoma (HNSCC). In some human tumors, including HNSCC, a number of mutations are caused by aberrantly activated DNA-modifying enzymes, such as ...
Dell'Oste, V., Gugliesi, F., Biolatti, M., Matteo Biolatti, Camilla Albano, Selina Pasquero, Valentina Dell’Oste, Landolfo, S., Francesca Gugliesi, Albano, C., Giuseppe Riva, Giancarlo Pecorari, Sergio Fernando Castillo Pacheco, Pecorari, G., Pasquero, S., Santo Landolfo   +15 more
core   +1 more source

The role of APOBEC proteins in HPV-induced carcinogenesis [PDF]

, 2022
Apolipoprotein B mRNA editing enzyme, catalytic polypeptide (APOBEC) are a family of evolutionarily conserved cytidine deaminases with the ability to bind and modify RNA and/or ssDNA. APOBEC1-4 have a number of functions in cells.
Frolíková, Daniela
core  

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

APOBEC affects tumor evolution and age at onset of lung cancer in smokers

Nature Communications
Most solid tumors harbor somatic mutations attributed to off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B). However, how APOBEC3A/B enzymes affect tumor evolution in the presence of exogenous mutagenic processes is largely unknown.
Tongwu Zhang, Jian Sang, Phuc H. Hoang, Wei Zhao, Jennifer Rosenbaum, Kofi Ennu Johnson, Leszek J. Klimczak, John McElderry, Alyssa Klein, Christopher Wirth, Erik N. Bergstrom, Marcos Díaz-Gay, Raviteja Vangara, Frank Colon-Matos, Amy Hutchinson, Scott M. Lawrence, Nathan Cole, Bin Zhu, Teresa M. Przytycka, Jianxin Shi, Neil E. Caporaso, Robert Homer, Angela C. Pesatori, Dario Consonni, Marcin Imielinski, Stephen J. Chanock, David C. Wedge, Dmitry A. Gordenin, Ludmil B. Alexandrov, Reuben S. Harris, Maria Teresa Landi   +30 more
doaj   +1 more source

Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis [PDF]

, 2019
Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate ...
Zotova, Irina, Pavlov, Youri, Stepchenkova, Elena   +2 more
core   +1 more source

Viral N protein hijacks deaminase-containing RNA granules to enhance SARS-CoV-2 mutagenesis

The EMBO Journal
Host cell-encoded deaminases act as antiviral restriction factors to impair viral replication and production through introducing mutations in the viral genome. We sought to understand whether deaminases are involved in SARS-CoV-2 mutation and replication,
Zhean Li, Lingling Luo, Xiaohui Ju, Shisheng Huang, Liqun Lei, Yanying Yu, Jia Liu, Pumin Zhang, Tian Chi, Peixiang Ma, Cheng Huang, Xingxu Huang, Qiang Ding, Yu Zhang   +13 more
doaj   +1 more source