Results 101 to 110 of about 121,312 (312)

'Good' platform-political reasons for 'bad' platform data. Zur sozio-technischen Geschichte der Plattformaktivitäten 'Fav', 'Retweet' und 'Like'

, 2014
In this article, we explore the relation between platform activities and their usage practices. Taking departure from predefined activities offered by social media platforms, this paper inquires into what may happen if platform features cater to opposing user practices.
Paßmann, Johannes, Gerlitz, Carolin
openaire   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

''Η ηθικοπολιτική ύπαρξη των Μ.Κ.Ο.''

, 2022
Στην παρούσα έρευνα θα επιχειρήσουμε, με σημείο εκκίνησης την ιστορική αναδρομή στη σύσταση των Μη Κυβερνητικών Οργανώσεων, να θέσουμε ως αντικείμενο συζήτησης τη φιλοσοφική αντίληψη του ωφελιμισμού και της πρακτικής της εφαρμογής στις ΜΚΟ. Έτσι, αρχής γενομένης από την ανάλυση του τρόπου και των βασικών αρχών μέσω των οποίων οι εν λόγω οργανώσεις ...
openaire   +1 more source

Quantification of apolipoprotein E receptors in human brain-derived cell lines by real-time polymerase chain reaction

, 2004
Apolipoprotein (apo) E4 is a risk factor for Alzheimer's disease (AD) and other neurodegenerative diseases, compared to wild-type apoE3. The mechanism(s) is unknown.
Owen, JS, Everett, D M, Murdock, P R, Everett, DM, Murdock, PR, Owen, J S, Dingwall, C, Thilakawardhana, S   +7 more
core   +1 more source

Clinical Significance of PD‐L1 and HLA Expression in Esophageal Squamous Cell Carcinoma in Response to Immunotherapy

Annals of Gastroenterological Surgery, EarlyView.
This study evaluated immune‐related biomarkers in esophageal squamous cell carcinoma treated with immune checkpoint inhibitors after postoperative recurrence. PD‐L1 expression in tumor‐associated macrophages and tumor cells, together with HLA class I downregulation and HLA‐DR expression, were associated with favorable responses to immunotherapy.
Kosuke Kanemitsu, Yoshiyuki Tagayasu, Yoshihiro Komohara, Cheng Pan, Rin Yamada, Yukio Fujiwara, Kazuto Harada, Keisuke Kosumi, Yoshifumi Baba, Masaaki Iwatsuki   +9 more
wiley   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Secondary Site Ligand for Integrin αVβ3 Enables Targeted mRNA Delivery

Angewandte Chemie, EarlyView.
Non‐orthosteric, low‐affinity ligands for integrin αVβ3, identified by fragment screening, achieve superselective nanoparticle targeting (ακ ≈ 3) of αVβ3‐overexpressing endothelial cells. Unlike traditional arginine–glycine–aspartate decorated particles, these fragment‐functionalized LNPs discriminate cells by receptor density and deliver mRNA to ...
Sebastian Bayer, María García‐García, Raffaele Senatore, Maria Stratoudaki, Alina Markhof, Angelika Berger‐Becvar, Anna Sophia Parianou, Christoph Rademacher   +7 more
wiley   +2 more sources

A protocol for the study of environmental risk factors and candidate gene–environment interactions in neurodegenerative disorders in Nigeria (SERGEND): A cross-sectional descriptive study

Journal of Clinical Sciences
Introduction: The risk of developing neurodegenerative disorders (NDDs) such as Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease and atypical parkinsonism (PDAP), has been alluded to arise predominantly from the interplay between ...
Oluwadamilola Omolara Ojo, Osigwe P Agabi, Ismail O Ishola, Olajumoke O Oshinaike, Sani A Abubakar, Kolawole W Wahab, Abiodun H Bello, Rufus O Akinyemi, Uduak Williams, Simon I Ozomma, Oluchi Ekenze, Emmanuel Iwuozo, Yakub W Nyandaiti, Francis I Ojini, Henry Houlden, John Hardy, Njideka Ulunma Okubadejo   +16 more
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

''Αλλαγή εννοιών στην ιστορία της τεχνολογίας: Η περίπτωση των εννοιών ''ήπιες'', ''εναλλακτικές'' και ''ανανεώσιμες'' ''μορφές'' ή ''πηγές'' ενέργειας.''

, 2016
Η εννοιολογική αλλαγή και εξέλιξη των εννοιών ''ήπιες'', ''εναλλακτικές'' και ''ανανεώσιμες'' ''μορφές'' ή ''πηγές'' ενέργειας όπως εντοπίζεται σε τεχνικά συγγράμματα και περιοδικά, συνέδρια του Ινστιτούτου Ηλιακής Τεχνολογίας και εφημερίδες.
openaire   +1 more source