Results 81 to 90 of about 121,312 (312)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

ApoE Allele Frequencies and Regional Richness of Intracellular Pathogens and Extracellular Pathogens

, 2020
Research into the genetic factors that contribute to human health and longevity has found that individual's apolipoprotein E (APOE) genotype is linked to their risk for developing Alzheimer's disease and cardiovascular diseases.
Mueller, Alison
core  

Summary statistics from epigenome-wide association studies and meta-analysis comparing APOE ε4 and APOE ε2 allele carriers in Generation Scotland

, 2020
These datasets contain full summary statistics for epigenome-wide association studies (EWASs) carried out using two methylation samples from the Generation Scotland: Scottish Family Health Study to investigate associations between blood-based DNA ...
Evans, Kathryn, Bermingham, Mairead, Amador, Carmen, Walker, Rosie, Campbell, Archie, Haley, Chris, Zeng, Yanni, Bretherick, Andrew, Marioni, Riccardo, Vaher, Kadi, McIntosh, Andrew, Rawlik, Konrad, Porteous, David, Morris, Stewart, Hayward, Caroline   +14 more
core   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

ApoE gene therapy: an overview and update

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix

, 2019
Rabbits with naturally high levels of cholesterol ester transfer protein (CETP), unlike rodents, have become an interesting animal model for the study of lipid metabolism and atherosclerosis, as they have similarities to humans in lipid metabolism ...
Claudius Thomé (488641), Christian Kremser, Monika Hunjadi, Andreas Ritsch, Christian Kremser (685496), Anja Beierfuß, Demissew Shenegelegn Mern (3753319), Demissew Shenegelegn Mern, Anja Beierfuß (488640), Monika Hunjadi (4571062), Andreas Ritsch (367896), Claudius Thomé   +11 more
core   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely hyperlipidemic mice

Journal of Lipid Research, 2002
We have previously reported that the introduction of macrophage apoE into mice lacking both apoE and the LDL receptor (apoE−/−/LDLR−/−) through bone marrow transplantation (apoE+/+/LDLR−/−→apoE−/−/LDLR−/−) produces progressive accumulation of apoE in ...
Sergio Fazio, Vladimir R. Babaev, Michael E. Burleigh, Amy S. Major, Alyssa H. Hasty, MacRae F. Linton   +5 more
doaj   +1 more source

Apolipoprotein E delivery by peritoneal implantation of encapsulated recombinant cells improves the hyperlipidaemic profile in apoE-deficient mice

, 2005
Plasma apolipoprotein E (apoE) is a 34-kDa polymorphic protein which has atheroprotective actions by clearing remnant lipoproteins and sequestering excess cellular cholesterol.
Dickson, G, Owen, JS, Heald, KA, Tagalakis, AD, Graham, IR, Diakonov, IA, Harris, JD, Mulcahy, JV   +7 more
core  

Anatomically-distinct genetic associations of APOE e{open}4 allele load with regional cortical atrophy in Alzheimer's disease

, 2009
APOE ɛ4 is the best-established genetic risk factor for sporadic Alzheimer's disease (AD). However, while homozygotes show greater disease susceptibility and earlier age of onset than heterozygotes, they may not show faster rates of clinical progression.
Williams, J., Nichols, T., Rao, A., Gibson, R.A., Whitcher, B., Borrie, M., Matthews, P.M., Filippini, N., Guzman, D., Loy-English, I., Wetten, S., Kertesz, A.   +11 more
core   +1 more source