Results 61 to 70 of about 43,185 (162)

Macrophage-specific apoE gene repair reduces diet-induced hyperlipidemia and atherosclerosis in hypomorphic Apoe mice. [PDF]

PLoS ONE, 2012
Apolipoprotein (apo) E is best known for its ability to lower plasma cholesterol and protect against atherosclerosis. Although the liver is the major source of plasma apoE, extra-hepatic sources of apoE, including from macrophages, account for up to 10 ...
Nathalie Gaudreault, Nikit Kumar, Victor R Olivas, Delphine Eberlé, Joseph H Rapp, Robert L Raffai   +5 more
doaj   +1 more source

Polymorphism of PPARG (P12A), APOA1 (G75A), and APOE (C112A and A158C) Genes in Children with Obesity and Arterial Hypertension: A Case-Control Study

Вопросы современной педиатрии, 2018
Background. The genetic nature of a comorbid development of obesity and arterial hypertension (AH) in children is poorly studied. In this regard, it is important to study genes, the polymorphism of which is associated with disturbances in both metabolic ...
Olga P. Kovtun, Margarita A. Ustyuzhanina   +1 more
doaj   +1 more source

PHARMACOGENETIC FEATURES OF THERAPY OF PATIENTS WITH ATHEROSCLEROSIS

Архивъ внутренней медицины, 2018
The complexity of therapy of lipid metabolism disorders is not only in comorbidity and polypragmasia, but also in predicting a genetically determined response to the treatment.
A. L. Khokhlov, A. N. Yavorsky, N. O. Pozdnyakov, J. V. Rybachkova, E. S. Emelianov, A. A. Khokhlov, A. E. Miroshnikov, S. O. Pozdnyakov   +7 more
doaj   +1 more source

Effects of toxic apolipoprotein E fragments on Tau phosphorylation and cognitive impairment in neonatal mice under sevoflurane anesthesia

Brain and Behavior, 2022
Background Anesthesia induces Tau phosphorylation and cognitive impairment in young, but not adult, mice. Apolipoprotein E (ApoE) may play a protective role in neuronal activity and injury repair, whereas its toxic fragments are reported to induce ...
Yang Yu, Man Yang, Xiaoli Zhuang, Jiacheng Pan, Yue Zhao, Yonghao Yu   +5 more
doaj   +1 more source

ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut–Brain Axis

, 2019
Sesamol, an antioxidant lignan from sesame oil, possesses neuroprotective bioactivities. The present work was aimed to elucidate the systemic protective effects of sesamol on cognitive deficits and to determine the possible link between gut and brain ...
Xinglin Zhang (146553), Rubing Shi (6743387), Tianlin Cui, Xiaoshuang Dai (6743399), Rubing Shi, Xuebo Liu (525911), Rui Qian (3328473), Zhigang Liu, Xinglin Zhang, Zhigang Liu (265354), Xu Shi (216330), Chuanqi Chu (6743384), Tianlin Cui (6743390), Chuanqi Chu, Yihang Zhao, Xuebo Liu, Tian Yuan, Junru Pan, Yan Hui, Tian Yuan (693527), Rui Qian, Xiaoshuang Dai, Yihang Zhao (6743393), Yan Hui (3749878), Junru Pan (6743396), Xu Shi   +25 more
core   +1 more source

Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico

Diabetes, Metabolic Syndrome and Obesity, 2020
Karina Gonzalez-Aldaco, Sonia Roman, Luis A Torres-Reyes, Arturo Panduro Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Health Sciences Center, University of Guadalajara, Guadalajara ...
Gonzalez-Aldaco K, Roman S, Torres-Reyes LA, Panduro A   +3 more
doaj  

APOE GENE POLYMORPHISM: THE IMPACT OF APOE4 ALLELE ON SYSTEMIC INFLAMMATION AND ITS ROLE IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE

Медицинская иммунология, 2018
ApoE is a member of lipoprotein family. It is the most common lipoprotein in the central nervous system (CNS), secreted by astrocytes, microglia, neurons and immunocompetent cells, including lymphocytes, monocytes and macrophages.
I. K. Malashenkova, S. A. Krynskiy, M. V. Mamoshina, N. A. Didkovskiy   +3 more
doaj   +1 more source

Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer’s Disease in the Lithuanian Population

Medicina, 2019
Background and objective: Neuroinflammation is one of the pathological pathways of Alzheimer’s disease (AD), mediating the progression of neurodegeneration.
Greta Pšemeneckienė, Kęstutis Petrikonis, Daiva Rastenytė   +2 more
doaj   +1 more source

Live Observation of Atherosclerotic Plaque Disruption in Apolipoprotein E-Deficient Mouse

Ultrasound International Open, 2015
Aim: The actual occurrence of spontaneous plaque rupture in mice has been a matter of debate. We report on an in vivo observation of the actual event of possible plaque disruption in a living ApoE-/- mouse.
V. Daeichin, J. C. Sluimer, K. van der Heiden, I. Skachkov, K. Kooiman, A. Janssen, B. Janssen, J. G. Bosch, N. de Jong, M. J. A. P. Daemen, A. F. W. van der Steen   +10 more
doaj   +1 more source

A protocol for the study of environmental risk factors and candidate gene–environment interactions in neurodegenerative disorders in Nigeria (SERGEND): A cross-sectional descriptive study

Journal of Clinical Sciences
Introduction: The risk of developing neurodegenerative disorders (NDDs) such as Alzheimer’s disease and related dementias (ADRD) and Parkinson’s disease and atypical parkinsonism (PDAP), has been alluded to arise predominantly from the interplay between ...
Oluwadamilola Omolara Ojo, Osigwe P Agabi, Ismail O Ishola, Olajumoke O Oshinaike, Sani A Abubakar, Kolawole W Wahab, Abiodun H Bello, Rufus O Akinyemi, Uduak Williams, Simon I Ozomma, Oluchi Ekenze, Emmanuel Iwuozo, Yakub W Nyandaiti, Francis I Ojini, Henry Houlden, John Hardy, Njideka Ulunma Okubadejo   +16 more
doaj   +1 more source