Results 171 to 180 of about 132,750 (308)

ApolipoproteinE⁺ Kupffer cells maintain immune homeostasis following liver transplantation by inducing CD8⁺ T cell exhaustion. [PDF]

iScience
Jia Z, Li X, Wang X, Zhou X, Cai H, Jiang P, Ding R, Liu H, Wang Y, Li S, Cai J.   +10 more
europepmc   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Divergent biological consequences of APOE isoforms across industrialized and non-industrial environments. [PDF]

PLoS Genet
Watowich MM, Petersen RM, Brassington L, Arner AM, Rodenberg G, Tan Boon Huat TBTA, Tam KL, Schellenberg E, Bin Mohd Sayed I, John E, Kahumbu JC, Muhoya B, Gurven M, Trumble BC, Njeru SN, Martins D, Ayroles JF, Lim YAL, Venkataraman VV, Wallace IJ, Kraft TS, Lea AJ.   +21 more
europepmc   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Hepatocyte-Specific <i>Nrf2</i> Deficiency Alters Cholesterol Metabolism, Leading to Mitigated Atherosclerosis in <i>ApoE</i>-Knockout Mice. [PDF]

Antioxidants (Basel)
Jiao J, Xu N, Hong Z, Chang L, Huang D, Yu Y, Wang Z, Li Y, Yu J, Guo J, Wang Y, Kuang L, Wang Y, Yang B, Zhao R, Hou Y, Wang H, Zhang Q, Xu P, Xu Y, Pi J, Fu J.   +21 more
europepmc   +1 more source

Connecting the dots: A narrative review of the relationship between heart failure and cognitive impairment

ESC Heart Failure, Volume 12, Issue 2, Page 1119-1131, April 2025.
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi, Maria Giulia Bellicini, Marianna Adamo, Andrea Pilotto, Marco Metra, Alessandro Padovani, Riccardo Proietti   +6 more
wiley   +1 more source

Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis

ESC Heart Failure, Volume 12, Issue 2, Page 1374-1385, April 2025.
Abstract Aims Inflammation plays a critical role in both the development and progression of heart failure (HF), which is a leading cause of morbidity and mortality worldwide. However, the causality between specific inflammation‐related proteins and HF risk remains unclear.
Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin   +9 more
wiley   +1 more source

ACE I/D polymorphism in Alzheimer’s disease

Open Life Sciences, 2008
Trebunova Marianna, Slaba Eva, Habalova Viera, Gdovinova Zuzana   +3 more
doaj   +1 more source

Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease. [PDF]

Alzheimers Dement
Shvetcov A, Thomson S, Graham ME, Hauger B, Keller JE, Smoyer CJ, Tague SE, Cho AN, Imam FB, Krish V, Global Neurodegeneration Proteomics Consortium (GNPC), Taylor MK, Mahnken JD, Sullivan DK, Reed JH, Burns JM, Slawson C, Swerdlow RH, Wilkins HM, Finney CA.   +19 more
europepmc   +1 more source

Engineering mRNA‐LNP Medicines for the Ageing Brain: Opportunities and Challenges for Neurodegenerative Diseases

Exploration, EarlyView.
This review highlights recent advances in engineering messenger RNA (mRNA)‐lipid nanoparticles (LNPs) to cross the ageing blood–brain barrier and target neurodegenerative diseases. It outlines design principles, delivery routes, and translational challenges, charting a roadmap towards clinical application of mRNA‐LNP therapeutics for neurodegenerative ...
Abdel Ali Belaidi, Denzil L. Furtado, Francesca Alves, Rebecca M. Nisbet, Scott Ayton, Ashley I. Bush   +5 more
wiley   +1 more source