Results 191 to 200 of about 132,750 (308)

The Endothelial CXCR Family in Vascular Health and Disease

iNew Medicine, EarlyView.
ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu, Yandi Wu, Suowen Xu, Yu Huang, Li Wang   +4 more
wiley   +1 more source

Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease. [PDF]

Nat Aging
Bhattarai P, Yilmaz E, Cakir EÖ, Tayran H, Haq I, Murphy D, Keller JN, Le Grand Q, Eschbach JO, Celikkaya H, Cosacak MI, Yüceer Korkmaz H, Lee AJ, Haage V, Ma Y, Wang X, Nelson N, Lin W, Zhang Y, Turgutalp B, de Leeuw SM, Patel R, Jülich D, İş Ö, Holley SA, De Jager PL, Freudenberg U, Werner C, St George-Hyslop P, Ertekin-Taner N, Debette S, Elahi FM, Fisher ES, Phatnani H, Teich AF, Tubbesing K, Bertucci T, Temple S, Nuriel T, Vardarajan BN, Mayeux R, Kizil C.   +41 more
europepmc   +1 more source

'Ireland'

, 2016
First ...
openaire   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

APOE in subjective cognitive decline: a systematic review and meta-analysis. [PDF]

J Neurol
Alonge P, Baiamonte L, Gerardi G, Torrente A, Lo Mauro E, Veronese N, Labate A, Monastero R.   +7 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

USF2-Mediated APOE-Cholesterol Signaling Promotes CTC Clustering and Metastasis in Non-Small Cell Lung Cancer. [PDF]

Int J Mol Sci
Li Z, Cui M, Sun L, Qin H, Shen X, Gao W.   +5 more
europepmc   +1 more source

Bidirectional Pathological Axis Between Alzheimer's Disease and Circadian Rhythm Disturbance: Mechanisms and Therapeutic Strategies

iNew Medicine, EarlyView.
This graphical abstract illustrates a bidirectional vicious cycle between Alzheimer’s disease (AD) and circadian rhythm disturbance (CRD). On the one hand, AD pathology, including amyloid‐β (Aβ) plaque deposition and tau hyperphosphorylation, may damage the suprachiasmatic nucleus (SCN) and disrupt melatonin signaling, leading to sleep fragmentation ...
Jiajia Qin, Xianfeng Yu, Yayu Wang, Xiaohan Song, Yuehua Wang, Zhixin Wang, Wei Miao, Xudong Yang, Jiajia Zhu, Xiaoqun Zhu, Maria‐Trinidad Herrero   +10 more
wiley   +1 more source

Prosocial helping behaviors attenuate accelerated cognitive decline driven by APOE ε4. [PDF]

Alzheimers Dement
Han SH, Faul JD.
europepmc   +1 more source

FOXC1: A Key Transcription Factor of VSMC‐Derived Foam Cell Formation in Atherosclerotic Plaque Instability

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life‐threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)‐derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC‐derived foam cells and IPH by analyzing data from human ...
Ling‐Lin Qian, Xue‐Ling Li, Li‐Hong Wang, Wei Yang, Yu Jiang   +4 more
wiley   +1 more source