Results 251 to 260 of about 132,750 (308)

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations. [PDF]

Nat Genet
Kurniansyah N, Tasaki S, Rehman H, Zhu C, Farrell J, Sherva R, Hauger R, Merritt VC, Panizzon M, Zhang R, Gaziano JM, Gim J, Lee K, Lee DY, Nho K, Vialle RA, Mukherjee S, Trittschuh EH, Lee AJ, Brickman AM, Cruchaga C, Risacher S, Greve DN, Crane P, Martin E, Bush WS, Mayeux R, Haines JL, Pericak-Vance MA, Logue M, Bennett DA, Barnes LL, Saykin A, Hohman T, Wang LS, Schellenberg GD, Ang TFA, Au R, Mez J, Lunetta KL, Zhang X, Farrer LA.   +41 more
europepmc   +1 more source

The second `'sacred disease'': Earlier euphemistic equivalent of `'Hansen's disease''

, 1996
openaire   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Apolipoprotein E promotes papillary thyroid carcinoma progression by activating PINK1/Parkin-mediated mitophagy. [PDF]

Transl Cancer Res
Sun S, Zuo S, Zhou Y, Song J, Wang Y, Liu S, Xue G, Lin X, Wu J.   +8 more
europepmc   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

Artery tertiary lymphoid organs encode a pathogenic high-affinity autoantibody-autoantigen pair in atherosclerosis. [PDF]

Nat Cardiovasc Res
Zhang C, Zhang X, Ran Y, Wang Z, Li L, Wang S, Zheng J, Zhang Y, Sun T, Li Y, Lu S, Hong M, Ma Z, Steffens S, Hristov M, Blanchet X, Zhu J, Dou X, Deng X, Dornmair K, Hu D, Lahiri S, Imhof A, Sachs N, Maegdefessel L, Xiao J, Zhang J, Wang Y, Hong H, Habenicht L, Weng X, Ge J, Weber C, Santovito D, Bashford-Rogers R, Mohanta SK, Ley K, Habenicht AJR, Yin C.   +38 more
europepmc   +1 more source

Psychological impacts of APOE genotype disclosure among Latinos in New York City: a randomized controlled trial. [PDF]

Alzheimers Dement
Ottman R, Wetmore JB, Leu CS, Uhlmann WR, Goldman J, Rodriguez S, Diaz Caro D, Cabán M, McCain S, Blasco D, Lantigua RA, Abraido-Lanza A, Chung WK, Roberts JS, Siegel K.   +14 more
europepmc   +1 more source

Monotropein mitigates atherosclerotic plaque vulnerability through circ_0140736/miR-495/SIRPα-mediated efferocytosis. [PDF]

iScience
Liu Y, Wu Z, Huang B, Ye W, Xu S, He W, Lan Y, Xiao C, Qin C, Gao W, Ye Z.   +10 more
europepmc   +1 more source

New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors. [PDF]

Psychogeriatrics
Gholami M, Ahmadi AA, Niaki MAA, Asouri M, Saeedi S, Amoli MM, Larijani B.   +6 more
europepmc   +1 more source