Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, EarlyView.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
Apolipoprotein E Gene ϵ4 Allele is Associated with Atherosclerosis in Multiple Vascular Beds
International Journal of General MedicineYouni Lin, Min Yang, Qifeng Liu, Yufu Cai, Zhouhua Zhang, Chongfei Xu, Ming Luo Center for Cardiovascular Diseases, Meizhou People’s Hospital, Meizhou, People’s Republic of ChinaCorrespondence: Youni Lin, Center for Cardiovascular Diseases, Meizhou ...
Lin Y +6 more
doaj
Apolipoprotein E (APOE) Promotes Cell Proliferation and Invasion in Glioma via the PI3K/AKT Signaling Pathway. [PDF]
Cancer Manag ResXia M, Chen K, Chen W, Ren Z, Li X.
europepmc +1 more source
Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research
Mass Spectrometry Reviews, EarlyView.Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik +3 more
wiley +1 more source
Elevated plasma klotho levels attenuate Alzheimer's disease pathologies and cognitive decline in APOE ε4 carriers. [PDF]
Alzheimers DementYang J +22 more
europepmc +1 more source
'Struggle, not destiny': Introduction to Pierre Raymond, 'Althusser's materialism'
, 2015 On the occasion of the publication of the translation of Pierre Raymond's text on Althusser's materialism, we attempt an introduction to his theoretical trajectory. We begin with his conception of the conflict between materialism and idealism in Le passage au matérialisme in 1973 and his thinking on the question of the history of sciences in ...
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Διοικητική μεταρρύθμιση ''Το σύστημα κινητικότητας των δημοσίων υπαλλήλων''
, 2019 The first part of the paper attempts to analyze the status of civil servants post-war and after the rehabilitation of the Republic, through the only tool that the Government had until that time and which was the Civil Service Code and as it was in force until the crisis period.
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Genetic and Pathological Testing Attitudes for Parkinson's Disease in At‐Risk Relatives
Movement Disorders Clinical Practice, EarlyView.Abstract Background Parkinson's disease (PD) is increasingly recognized as a neurodegenerative disorder with a broad clinical spectrum and diverse biomarkers enabling early detection. α‐synuclein seed amplification assays (SAA) and genetic testing now allow identification of PD pathology in asymptomatic individuals.
Tal Weil +5 more
wiley +1 more source
Movement Disorders Clinical Practice, EarlyView.Abstract Background Visuospatial deficits in Parkinson's disease (PD) often precede dementia and complicate daily functioning. Alzheimer's disease (AD) pathology and α‐synuclein aggregation frequently co‐occur in PD, but their combined impact on cognition is unclear.
David Ledingham +8 more
wiley +1 more source