Results 141 to 150 of about 131,925 (308)

''Wist U ervan?''

, 2007
De vuurwerkramp in Enschede, de ingestorte grachttrap in Utrecht, de moord op Theo van Gogh, de aanslagen van 11 september, de Bijlmerramp, de verspreiding van de SARS-pandemie, de Bijlmerramp ... Welke ramp er ook geschiedt, welke fouten er ook worden gemaakt, steevast wordt de vraag gesteld: waren de betrokken autoriteiten op de hoogte en zo ja, had ...
openaire   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Interaction between Testosterone and Apolipoprotein E ε4 Status on Cognition in Healthy Older Men [PDF]

, 2005
Reduced testosterone levels have been implicated as a potential causative factor in cognitive decline with older age. Men who possess the apolipoprotein E (APOE) 4 allele have an increased risk of developing Alzheimer’s disease; however, no studies have
Chubb, S.A.P., Foster, J.K., Drummond, P.D., Burkhardt, M.S., Yeap, B.B., Clarnette, R.M., Bruce, D.G.   +6 more
core  

Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression

Annals of Neurology, EarlyView.
Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low, Jeffrey L. Gunter, Mingzhao Hu, Sheelakumari Raghavan, Scott A. Przybelski, Christopher G. Schwarz, Kejal Kantarci, Val J. Lowe, Ronald C. Petersen, Jonathan Graff‐Radford, Clifford R. Jack Jr, Prashanthi Vemuri   +11 more
wiley   +1 more source

Van 'ancien' naar 'nouveau'

, 2000
"De redactie daagt u uit te reageren op dit stuk. In het volgende nummer zal de auteur de discussie aangaan en uw reacties onder de loep nemen, aan de hand waarvan tevens getracht zal worden een karakterisering te geven van een mogelijk 'nouveau regime'.
openaire   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, EarlyView.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols‐Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius   +24 more
wiley   +1 more source

APOE-E4 and APOE-491A polymorphisms in individuals with subjective memory loss

, 2002
The accurate clinical diagnosis of Alzheimer’s disease can only be made with a high degree of certainty in specialized centres. The identification of predictive or diagnostic genetic factors may improve accuracy of disease prediction or diagnosis.
S. Laws (23325424), David Groth (9263895), R Clarnette (13352523)   +2 more
core  

Blood Biomarkers of Alzheimer's Disease and Patterns of Structural Brain Changes in the Community

Annals of Neurology, EarlyView.
Objective We aimed to investigate the associations between Alzheimer's disease (AD)‐related blood biomarkers and changes in brain volumes and cerebrovascular burden in community‐dwelling older adults. Methods We included 361 dementia‐free participants with a Mini‐Mental State Examination (MMSE) score ≥ 27 and without prior cerebrovascular events from a
Martina Valletta, Davide Liborio Vetrano, Erika J. Laukka, Grégoria Kalpouzos, Javier Oltra, Debora Rizzuto, Marco Canevelli, Claudia Fredolini, Chengxuan Qiu, Bengt Winblad, Laura Fratiglioni, Giulia Grande   +11 more
wiley   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

'Good' platform-political reasons for 'bad' platform data. Zur sozio-technischen Geschichte der Plattformaktivitäten 'Fav', 'Retweet' und 'Like'

, 2014
In this article, we explore the relation between platform activities and their usage practices. Taking departure from predefined activities offered by social media platforms, this paper inquires into what may happen if platform features cater to opposing user practices.
Paßmann, Johannes, Gerlitz, Carolin
openaire   +1 more source