Results 241 to 250 of about 176,190 (308)

Alcohol use and APOE ε4 interaction with cognitive domains among American adults from diverse racial/ethnic groups: A HABS‐HD study

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 2, June 2026.
Abstract Introduction We investigated the interaction between alcohol use behavior and apolipoprotein E (APOE) ε4 on cognitive domains among non‐Hispanic Black (NHB), Hispanic, and non‐Hispanic White (NHW) individuals. Methods Using the Health and Aging Brain Study–Health Disparities data, we analyzed 2143 adults aged 50+ using linear regression ...
Edna P. Mendoza‐Villena, Malinee Neelamegam, Nicole Phillips, Leigh Johnson, Lubnaa Abdullah, James Hall, Sid O'Bryant, Eun‐Young Mun, Shea J. Andrews, Robert Barber, Gita A. Pathak, Mohammad Housini, Kai Zhang, Zhengyang Zhou   +13 more
wiley   +1 more source

Modeling <i>APOE</i>, morbidity, and mortality: a reproducibility challenge for genetic epidemiology. [PDF]

Front Genet
Häggström Gunfridsson E.
europepmc   +1 more source

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1494-1502, June 2026.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

The APOE paradox: divergent genetic influences on hemorrhagic stroke risk-A meta-analysis. [PDF]

Front Stroke
Nath M, Rai A, Misra S, Kumar P.
europepmc   +1 more source

Physiology, pathology and therapeutic potential of microglial triggering receptor expressed on myeloid cells 2 signalling: A narrative update

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
TREM2hi microglia and macrophages exert distinct roles in neurological diseases. Enhancing TREM2 signalling supports pathological protein or debris clearance and mitigates inflammation in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, demyelination disorders and stroke, whereas blocking TREM2 may alleviate tauopathy and ...
Zhe Kong, Libin Shen, Daqing Ma, Jinchao Hou   +3 more
wiley   +1 more source

APOE ε4 and Accelerated Cognitive Decline Among Cognitively Healthy Middle-Aged and Older Adults.

JAMA Netw Open
Chung YE, Chung RH, Hsu CC, Liu YL, Lai RH, Hung WJ, Wu RC, Jiang YJ, Chuang SY, Tsai SF, Kuo CC, Hsiung CA, Chen WJ.   +12 more
europepmc   +1 more source

The second `'sacred disease'': Earlier euphemistic equivalent of `'Hansen's disease''

, 1996
openaire   +1 more source

Glia Are Bussin’: How Single‐Cell and Spatial Transcriptomics Enlighten the Role of Neuroglia in Spinal Cord Injury and Regeneration

Glia, Volume 74, Issue 6, June 2026.
Neuroglia have been extensively profiled using single‐cell genomics, improving our understanding of their dynamics after spinal cord injury. A meta‐analysis of five single‐cell time‐course genomic studies reveals heterogeneity underscoring important challenges for interpretation.
Julio Mejia, Philip J. Horner
wiley   +1 more source

CD80⁺ Macrophage-Induced IL-17⁺CD8⁺ T cells accumulate in hyperlipidemic patients and murine vascular lesions to promote atherosclerotic progression. [PDF]

Cell Commun Signal
Wang Y, Li P, Li W, Zou Y, Zhao Y, Ma L, Zhao T, Chai X, Liu S, Yuan Z, Hassan M, Wang T, Yu C.   +12 more
europepmc   +1 more source

A Cross‐Disease Microglial Transcriptional Program Characterizes Neurodegeneration and Highlights SPP1 as a Biomarker

Glia, Volume 74, Issue 6, June 2026.
Distinct microglial subpopulations are depicted, highlighting variations in gene expression and functional roles in response to specific disease conditions and the complexity of microglial activation and differentiation in neurodegeneration. ABSTRACT Microglial cells are key players in maintaining brain homeostasis and responding to pathological ...
Alessandro Palma, Roberta Stefanelli, Francesco Trenta, Chiara Projetti, Greta Massa, Sonia Canterini, Maria Teresa Fiorenza   +6 more
wiley   +1 more source