Results 231 to 240 of about 176,190 (308)

Uncovering the impact of the cardiovascular system on cerebrovascular health using MRI

open access: yesExperimental Physiology, EarlyView.
Abstract Human cerebrovasculature is finely tuned to enable local changes in blood flow to meet the brain's demands, whilst protecting the brain from systemic changes in blood pressure, both acutely during a heartbeat and chronically over time. This review summarises cerebrovascular structure and function, their role in disease and neurodegeneration ...
Ian D. Driver, Kevin Murphy
wiley   +1 more source

Slc7a11-Mediated Cystine/Glutamate Antiport Reprograms Macrophage Polarization and Ameliorates Atherosclerosis. [PDF]

open access: yesMedComm (2020)
Zhou S   +12 more
europepmc   +1 more source

TREM2+ macrophages accumulate in childhood IgA nephropathy and soluble TREM2 represents a reliable non‐invasive biomarker

open access: yesExperimental Physiology, EarlyView.
Abstract IgA nephropathy (IgAN) is a common type of primary glomerulonephritis in children. The pathogenesis of childhood IgAN remains unclear, and there is a lack of effective non‐invasive biomarkers for this disease. Single‐cell RNA sequencing was performed in children with IgAN to delineate cellular and molecular compositions, and subcluster ...
Ling Yu   +7 more
wiley   +1 more source

Neuroprotective roles of klotho: Molecular pathways and therapeutic implications for cognitive health in neurological and psychiatric diseases

open access: yesExperimental Physiology, EarlyView.
Abstract Klotho, a pleiotropic protein initially identified for its role in kidney function, has garnered significant attention for its neuroprotective properties in various neurodegenerative diseases. It regulates key processes, such as oxidative stress, neuroinflammation, synaptic plasticity and myelination, all crucial for maintaining neuronal ...
Amir Arsalan Ghahari   +7 more
wiley   +1 more source

Blood PCSK9 Impacts Alzheimer's Disease Risk in an <i>APOE</i> Genotype-Dependent Manner: A Prospective Cohort Study. [PDF]

open access: yesHealth Sci Rep
Tao Q   +10 more
europepmc   +1 more source

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