Results 101 to 110 of about 132,444 (256)

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Interconnection at the level of uric acid and apolipoprotein e in the blood of persons with normal and hyper lipidemia

Атеросклероз, 2011
To investigate the levels of uric acid and apoE in patients with normo- and hyperlipidemia. The serum lipids, apolipoproteins and uric acid levels were measured with Chronolab (Switzerland) kits in 78 patients: 53 patients with normolipidemia and 25 ...
E. R. Boijko, A. O. Ovechkin, A. M. Kaneva, N. N. Potolitsyna   +3 more
doaj  

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Association of Apolipoprotein e2 Allele with Insulin Resistance and Risk of Type 2 Diabetes Mellitus Among an Admixed Population of Mexico

Diabetes, Metabolic Syndrome and Obesity, 2020
Karina Gonzalez-Aldaco, Sonia Roman, Luis A Torres-Reyes, Arturo Panduro Department of Molecular Biology in Medicine, Civil Hospital of Guadalajara “Fray Antonio Alcalde”, Health Sciences Center, University of Guadalajara, Guadalajara ...
Gonzalez-Aldaco K, Roman S, Torres-Reyes LA, Panduro A   +3 more
doaj  

Effect of fenofibrate and atorvastatin on VLDL apoE metabolism in men with the metabolic syndrome

Journal of Lipid Research, 2012
We examined the effects of fenofibrate and atorvastatin on very low density lipoprotein (VLDL) apolipoprotein (apo)E metabolism in the metabolic syndrome (MetS). We studied 11 MetS men in a randomized, double-blind, crossover trial.
Esther M.M. Ooi, Theodore W.K. Ng, Gerald F. Watts, Dick C. Chan, P. Hugh R. Barrett   +4 more
doaj   +1 more source

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model [PDF]

, 2012
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases.
Tikva Vogel, Zensi, Anja, von Briesen Hagen, Kreuter Jörg, Worek Franz, Tschickardt, Sabrina E., Sascha L Wien, Jörg Kreuter, Wien Sascha L., Vogel Tikva, Sabrina E Tschickardt, Wladislaw Maier, Vogel, Tikva, Sylvia Wagner, Claus U Pietrzik, Maier Wladislaw, Zensi Anja, Wien, Sascha L., Maier, Wladislaw, Tschickardt Sabrina E., Wagner, Sylvia, Pietrzik Claus U., Anja Zensi, Kreuter, Jörg, Worek, Franz, Hagen von Briesen, Pietrzik, Claus Ulrich, Briesen, Hagen von, Wagner Sylvia, Franz Worek   +29 more
core   +2 more sources

Low SLC8A1 in Colorectal Cancer Dictates Radiotherapy Resistance Through Calcium‐Dependent ANXA2+sEVs Driving M2 Polarization of TAMs

Advanced Science, EarlyView.
SLC8A1 deficiency in colorectal cancer cells increases intracellular calcium signaling, promoting the secretion of ANXA2‐enriched small extracellular vesicles. These vesicles reprogram tumor‐associated macrophages towards an M2 phenotype, which in turn fosters a tumor microenvironment conducive to radioresistance and is associated with poor patient ...
Yimin Fang, Jinghan Zhu, Qian Xiao, Qichun Wei, Xiujing He, Ping Li, Kai Jiang, Yue Liu, Yeting Hu, Weiwei Yu, Chuansheng Guo, Sheng Chen, Jian Zhao, Siqi Dai, Jingsun Wei, Hang Yang, Tongtong Bu, Kefeng Ding, Haiyan Chen   +18 more
wiley   +1 more source

Serial Molecular‐Microstructural Multimodal Intravascular Imaging of Atherosclerotic Plaques in Mice

Advanced Science, EarlyView.
A novel longitudinal molecular and microstructural intravascular imaging approach is developed to study murine atherosclerosis. The technique combines a unique surgical model with a miniaturized multimodal device to detect macrophage activity and lipid simultaneously.
Jiawen Li, Joanne T. M. Tan, Lei Xiang, Jiandi Liu, Ayla Hoogendoorn, Victoria A. Nankivell, Lauren Sandeman, Richard Le, Rouyan Chen, Robert A. McLaughlin, Peter J. Psaltis, Johan W. Verjans, Christina A. Bursill   +12 more
wiley   +1 more source

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix

, 2019
Rabbits with naturally high levels of cholesterol ester transfer protein (CETP), unlike rodents, have become an interesting animal model for the study of lipid metabolism and atherosclerosis, as they have similarities to humans in lipid metabolism ...
Claudius Thomé (488641), Christian Kremser, Monika Hunjadi, Andreas Ritsch, Christian Kremser (685496), Anja Beierfuß, Demissew Shenegelegn Mern (3753319), Demissew Shenegelegn Mern, Anja Beierfuß (488640), Monika Hunjadi (4571062), Andreas Ritsch (367896), Claudius Thomé   +11 more
core   +1 more source