The APOE ε2 allele is associated with risk of neovascular age-related macular degeneration in a Russian cohort [PDF]
Вавиловский журнал генетики и селекцииAge-related macular degeneration (AMD) is a progressive disease that leads to blindness and is the cause of visual impairment in an aging population. Apolipoprotein E (ApoE) is one of the key proteins in lipoprotein metabolism.
O. S. Kozhevnikova +5 more
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Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping [PDF]
Alzheimer’s Research & Therapy, 2022 Background Genetic variants within the APOE locus may modulate Alzheimer’s disease (AD) risk independently or in conjunction with APOE*2/3/4 genotypes.
Michael E. Belloy +28 more
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The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients [PDF]
Journal of Medical Biochemistry, 2023 Background: Besides good glycemic control, also control of lipid levels can effectively prevent or delay late type 2 diabetes (T2D) complications. As apolipoprotein E (APOE) and paraoxonase 1 (PON1) were shown to suppress atherosclerosis, we investigated
Klen Jasna, Goričar Katja, Dolžan Vita
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Familial dysbetalipoproteinemia: highly atherogenic and underdiagnosed disorder
Кардиоваскулярная терапия и профилактика, 2021 Familial dysbetalipoproteinemia (FD) is a genetic, highly atherogenic disorder. The penetrance of FD depends on the patient’s lifestyle and concomitant diseases. Despite the fact that FD was described almost half a century ago, it is still insufficiently
A. V. Blokhina +3 more
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Journal of Integrative Neuroscience, 2022 Background: Cognitive interventions (CIs) in the elderly are activities that seek to improve cognitive performance and delay its deterioration. Our objectives were to study potential genetic predictors of how a CI program may influence immediate and ...
Pedro Montejo Carrasco +4 more
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Effects of prolactin on movement disorders and APOE, GFAP, and PRL receptor gene expression following intracerebral hemorrhage in rats [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Intracerebral hemorrhage (ICH) occurs mostly in the striatum. In ICH, blood prolactin level increases 3-fold. The effects of intracerebroventricular injection (ICV) of prolactin on motor disorders will be investigated. Materials and Methods:
Shiba Yousefvand +6 more
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The Suggestive Effect of Apo A, Apo B, and Apo A/Apo B on Erectile Dysfunction [PDF]
The Journal of Sexual Medicine, 2021 ABSTRACTBackgroundErectile dysfunction (ED) is closely related to coronary heart disease (CHD). Apolipoprotein (Apo) A1, Apo B, and Apo A/Apo B are known to be predictive factors for CHD. They are not yet a definite laboratory marker for the diagnosis of ED in cardiology. Therefore, we investigated the association between Apo A1, Apo B, and Apo A/Apo B,
Xiucheng, Li, Dongjie, Li
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APOE4 dysregulates autophagy in cultured cells
Autophagy Reports, 2022 Human APOE4 (apolipoprotein E4 isoform) is a powerful genetic risk factor for late-onset Alzheimer disease (AD). Many groups have investigated the effect of APOE4 on the degradation of amyloid β (Aβ), the main component of plaques found in the brains of ...
Gianna M. Fote, Joan S. Steffan
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تأثیر هشت هفته تمرین هوازی بر برخی عوامل درگیر در متابولیسم کلسترول در هیپوکمپ و نقش آن در بهبود عملکرد شناختی رت‌های نر ویستار [PDF]
فیزیولوژی ورزشی, 2020 در مطالعات به‌طور گسترده به متابولیسم لیپیدهای گردش خون توجه شده است، اما در سال‌های اخیر به متابولیسم لیپید در مغز به‌دلیل ارتباط با برخی اختلال‌های عصبی توجه بیشتری شده است.
زهرا سرلک +3 more
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ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. [PDF]
, 2021 Apolipoprotein E (ApoE), an important mediator of lipid transportation in plasma and the nervous system, plays a large role in diseases such as atherosclerosis and Alzheimer's.
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