Results 141 to 150 of about 121,312 (312)

Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

, 2017
The hepatic anti-inflammatory potential of hexane extracts of Dioscorea batatas Decne edible part(EDH-1e) and bark(EDH-2b) were investigated in Western-type diet-fed apolipoprotein E null [ApoE(-/-)] mice and HepG2 cells. EDH-1e and EDH-2b suppressed the 
표석능, 강세찬, 손은수, 이성률, 구현정, 손은화, 장광진   +6 more
core  

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference. [PDF]

INTRODUCTION: The apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimers disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid-beta and tau pathologies but also lipid
Davis, Albert A, Saleh, Rasha N M, Huang, Yadong, Sible, Isabel, Paolo, Gilbert Di, Bowman, Gregory, Blue, Elizabeth E., Johnson, Lance, Lawler, Paige E., Sible, Isabel J., Soranno, Andrea, Liu, Chia Chen, Ramachandran, Kapil V., Lamb, Bruce, Davis, Albert A., Marino, Claudia, Tuckey, Ryan A, Gate, David, Wellington, Cheryl L, Zhao, Na, Ramachandran, Kapil, Narayan, Priyanka, Miller, Justin, Raulin, Ana-Caroline, Narayan, Priyanka S., Oosthoek, Marlies, Guen, Yann, Tsai, Li-Huei, Michaelson, Danny M, Shah, Nilomi, Herz, Joachim, Paolo, Gilbert, Belloy, Michael, Weninger, Stacie C., Weninger, Stacie C, Strickland, Michael, Di Paolo, Gilbert, Chen, Xiaoying, Marcora, Edoardo, Carrillo, Maria C., Garretti, Francesca, Johnson, Lance A, Mahinrad, Simin, Golden, Lesley R., Johnson, Lance A., Lamb, Bruce T., Saleh, Rasha N.M., Goate, Alison M, Bowman, Gregory R, Golden, Lesley, Karch, Celeste, Wellington, Cheryl L., Naslavsky, Michel S., Belloy, Michael E., Raulin, Ana Caroline, Blue, Elizabeth E, Goate, Alison, Sexton, Claire, Davis, Albert, Guen, Yann Le, Sible, Isabel J, Naslavsky, Michel, Wellington, Cheryl, Miller, Justin J., Saleh, Rasha, Iadecola, Costantino, Lawler, Paige, Heinecke, Jay, Weninger, Stacie, Kloske, Courtney, Koppes-den Hertog, Sascha, Tuckey, Ryan A., van der Kant, Rik, Thierry, Manon, Kloske, Courtney M., Karch, Celeste M, Michaelson, Danny M., Tuckey, Ryan, Ulrich, Jason, Bowman, Gregory R., Carrillo, Maria C, Belloy, Michael E, Ulrich, Jason D., Holtzman, David, Heinecke, Jay W, Koppes-den Hertog, Sascha J, Narayan, Priyanka S, Naslavsky, Michel S, Liu, Chia-Chen, Yassine, Hussein N., Le Guen, Yann, Kloske, Courtney M, Miller, Justin J, Tcw, Julia, Strickland, Michael R., Holtzman, David M., Strickland, Michael R, Kanekiyo, Takahisa, Bu, Guojun, Morganti, Josh, Blue, Elizabeth, Litvinchuk, Alexandra, Ramakrishnan, Abhirami, Wang, Na, Yassine, Hussein, Morganti, Josh M., Lawler, Paige E, Goate, Alison M., Lamb, Bruce T, Michaelson, Danny, Heinecke, Jay W., Yassine, Hussein N, Koppes-den Hertog, Sascha J., Ramachandran, Kapil V, Shue, Francis, Chiba-Falek, Ornit, Carrillo, Maria, Ulrich, Jason D, Saleh, Rasha N. M., Holtzman, David M, Khvorova, Anastasia, Karch, Celeste M., Tsai, Li Huei, Robert, Aiko   +123 more
core   +1 more source

Progressive myoclonus epilepsy in Down syndrome with Alzheimer's disease: An 11‐year longitudinal study and proposed diagnostic red flags

Epilepsia Open, EarlyView.
Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi, Ezio Calò, Maria Teresa Di Claudio, Carmela Pia Ferro, Umberto Costantino, Elio Perrone, Raffaela Rita Latino   +6 more
wiley   +1 more source

Van 'ancien' naar 'nouveau'

, 2000
"De redactie daagt u uit te reageren op dit stuk. In het volgende nummer zal de auteur de discussie aangaan en uw reacties onder de loep nemen, aan de hand waarvan tevens getracht zal worden een karakterisering te geven van een mogelijk 'nouveau regime'.
openaire   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Beckett's and Murakami's 'Vaguened' Worlds

, 2022
APPROVED
openaire   +1 more source

Structural and resting-state MRI detects regional brain differences in young and mid-age healthy APOE-e4 carriers compared with non-APOE-e4 carriers

, 2016
The presence of the e4 allele of the apolipoprotein E (APOE) gene is the best-known genetic risk factor for Alzheimer's disease. In this study, we investigated the link between functional and behavioural differences and regional brain volume and cortical
Sarah King (4460617), Jennifer Rusted (4460485), Simon L Evans (16039634), Naji Tabet (4461808), Nicholas Dowell (4462081), Paul S Tofts (16048253)   +5 more
core  

ApoE-calypse tau: ApoE–tau synergy in Alzheimer’s disease

International audienceAlzheimer’s disease (AD), the most common cause of dementia, is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles.
Holtzman, David, Gratuze, Maud, Bordier, Chiara, Ulrich, Jason D, Lennol, Matthew Paul, Holtzman, David M, Kamelher, Léana, Ulrich, Jason   +7 more
core   +1 more source

Interaction between Testosterone and Apolipoprotein E ε4 Status on Cognition in Healthy Older Men

, 2005
Reduced testosterone levels have been implicated as a potential causative factor in cognitive decline with older age. Men who possess the apolipoprotein E (APOE) 4 allele have an increased risk of developing Alzheimer’s disease; however, no studies have
Chubb, S.A.P., Foster, J.K., Drummond, P.D., Burkhardt, M.S., Yeap, B.B., Clarnette, R.M., Bruce, D.G.   +6 more
core   +1 more source

Gut microbiota‐mediated immune and metabolic dysregulation in coronary artery disease progression and prognosis

iMeta, EarlyView.
The gut microbiota has emerged as a metabolically active endocrine‐like organ with a crucial role in coronary artery disease (CAD), yet its contribution to adverse clinical outcomes remains incompletely understood. In this prospective cohort of 319 participants, we integrated metagenomic and metabolomic profiling with longitudinal follow‐up over a ...
Honghong Liu, Siqin Feng, Lifeng Liang, Muyun Tang, Yifei Wang, Yiyang Wang, Zhiyu Zhang, Haiping Xing, Chenhong Zhang, Ran Tian, Shuyang Zhang   +10 more
wiley   +1 more source