Results 11 to 20 of about 122,052 (212)

Apolipoprotein D [PDF]

Gene, 2020
ApoD is a 25 to 30 kDa glycosylated protein, member of the lipocalin superfamily. As a transporter of several small hydrophobic molecules, its known biological functions are mostly associated to lipid metabolism and neuroprotection. ApoD is a multi-ligand, multi-function protein that is involved lipid trafficking, food intake, inflammation ...
Eric Rassart, Frederik Desmarais, Ouafa Najyb, Karl-F. Bergeron, Catherine Mounier   +4 more
openaire   +2 more sources

Apolipoprotein M [PDF]

Lipids in Health and Disease, 2004
AbstractApolipoprotein M (apoM) is a 26-kDa protein that is mainly associated with high-density lipoprotein (HDL) in human plasma, with a small proportion present in triglyceride-rich lipoproteins (TGRLP) and low-density lipoproteins (LDL). Human apoM gene is located in p21.31 on chromosome 6 (chromosome 17, in mouse).
Nilsson-Ehle Peter, Zhang Xiaoying, Luo Guanghua, Xu Ning   +3 more
openaire   +3 more sources

Liver X receptors are regulators of adipocyte gene expression but not differentiation

Journal of Lipid Research, 2004
The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not well defined.
Sarah Hummasti, Bryan A. Laffitte, Michael A. Watson, Cristin Galardi, Lily C. Chao, Lakshman Ramamurthy, John T. Moore, Peter Tontonoz   +7 more
doaj   +1 more source

Varied Relationship of Lipid and Lipoprotein Profiles to Liver Fat Content in Phenotypes of Metabolic Associated Fatty Liver Disease

Frontiers in Endocrinology, 2021
BackgroundProgressive overloads of intrahepatic triglycerides are related to metabolic dysregulation of multiple lipid and lipoprotein profiles, but whether similar dose effects are found in each subtype of metabolic associated fatty liver disease (MAFLD)
Tingfeng Wu, Junzhao Ye, Congxiang Shao, Fuxi Li, Yansong Lin, Qianqian Ma, Wei Wang, Shiting Feng, Bihui Zhong   +8 more
doaj   +1 more source

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

Journal of Lipid Research, 2019
The pharmacologic inhibition of proprotein convertase subtilisin-kexin type 9 (PCSK9) lowers lipoprotein (a) [Lp(a)] concentrations. However, the impact of genetic PCSK9 loss-of-function variants (LOFVs) on Lp(a) is uncertain.
Matthew T. Mefford, Santica M. Marcovina, Vera Bittner, Mary Cushman, Todd M. Brown, Michael E. Farkouh, Sotirios Tsimikas, Keri L. Monda, J. Antonio G. López, Paul Muntner, Robert S. Rosenson   +10 more
doaj   +1 more source

D-4F, an apoA-1 mimetic, decreases airway hyperresponsiveness, inflammation, and oxidative stress in a murine model of asthma[S]

Journal of Lipid Research, 2011
Asthma is characterized by oxidative stress and inflammation of the airways. Although proinflammatory lipids are involved in asthma, therapies targeting them remain lacking. Ac-DW F KA F YDKVAEK F KEA F NH2 (4F) is an apolipoprotein (apo)A-I mimetic that
S.D. Nandedkar, D. Weihrauch, H. Xu, Y. Shi, T. Feroah, W. Hutchins, D.A. Rickaby, N. Duzgunes, C.A. Hillery, K.S. Konduri, Jr.K.A. Pritchard   +10 more
doaj   +1 more source

Cellular cholesterol efflux in heterozygotes for Tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size

Journal of Lipid Research, 2000
Tangier disease (TD), caused by mutations in the ATP-binding cassette 1 (ABC-1) gene, is a rare genetic disorder characterized by severe deficiency of high density lipoproteins (HDL) in the plasma, hypercatabolism of HDL, and defective apolipoprotein ...
Margaret E. Brousseau, Gretchen P. Eberhart, Josée Dupuis, Bela F. Asztalos, Allison L. Goldkamp, Ernst J. Schaefer, Mason W. Freeman   +6 more
doaj   +1 more source

Apolipoproteins and cancer [PDF]

Cancer Medicine, 2019
AbstractThe role of apolipoproteins in cardiovascular disease has been well investigated, but their participation in cancer has only been explored in a few published studies which showed a close link with certain kinds of cancer. In this review, we focused on the function of different kinds of apolipoproteins in cancers, autophagy, oxidative stress ...
Liwen Ren, Jie Yi, Wan Li, Xiangjin Zheng, Jinyi Liu, Jinhua Wang, Guanhua Du   +6 more
openaire   +3 more sources

Dyslipidemia and its relationship with chronic non-communicable diseases (according to the MERIDIAN-RO study)

Медицинский совет, 2015
MERIDIAN-RO, a prospective cohort cross-sectional study with retrospective component, aimed to evaluate the incidence of lipid metabolism disorders in the Ryazan region and their relationship with chronic non-communicable diseases. In 2011, 1,622 people (
E. V. Filippov, Y. A. Balanova
doaj   +1 more source

A Current Update on the Role of HDL-Based Nanomedicine in Targeting Macrophages in Cardiovascular Disease

Pharmaceutics, 2023
High-density lipoproteins (HDL) are complex endogenous nanoparticles involved in important functions such as reverse cholesterol transport and immunomodulatory activities, ensuring metabolic homeostasis and vascular health. The ability of HDL to interact
Alankrita Rani, Gunther Marsche
doaj   +1 more source