Results 21 to 30 of about 122,052 (212)

Interaction between SNPs in the RXRA and near ANGPTL3 gene region inhibits apoB reduction after statin-fenofibric acid therapy in individuals with mixed dyslipidemia

Journal of Lipid Research, 2012
The mixed dyslipidemia phenotype is characterized by elevated triglycerides (TG), low HDL cholesterol (HDL-C), increased ApoB levels, and premature coronary atherosclerosis.
Li Ma, Christie M. Ballantyne, John W. Belmont, Alon Keinan, Ariel Brautbar   +4 more
doaj   +1 more source

Особенности дислипидемических нарушений у больных с шизофренией при терапии галоперидолом и рисперидоном в зависимости от носительства некоторых генетических полиморфизмов

Современная терапия психических расстройств, 2019
Цель исследования – определение роли полиморфизма некоторых генов в развитии дислипидемических нарушений при психофармакотерапии у больных параноидной шизофренией.
Штань, М.С., Озорнин, А.С., Говорин, Н.В.   +2 more
doaj   +1 more source

Age-related behavioural abnormalities in C57BL/6.KOR–Apoe shl mice

Translational Neuroscience
Spontaneously hyperlipidaemic (Apoeshl) mice were discovered in 1999 as mice lacking apolipoprotein E (ApoE) owing to a mutation in the Apoe gene. However, age-related behavioural changes in commercially available Apoeshl mice have not yet been clarified.
Ueno Hiroshi, Takahashi Yu, Mori Sachiko, Kitano Eriko, Murakami Shinji, Wani Kenta, Miyazaki Tetsuji, Matsumoto Yosuke, Okamoto Motoi, Ishihara Takeshi   +9 more
doaj   +1 more source

Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis

Journal of Lipid Research, 2011
Expression of apoE in adipocytes has been shown to have an important role in modulating adipocyte triglyceride (TG) metabolism and gene expression that is independent of circulating and extracellular apoE.
Zhi H. Huang, Nobuyo Maeda, Theodore Mazzone   +2 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content

Journal of Lipid Research, 2015
ApoA5 has a critical role in the regulation of plasma TG concentrations. In order to determine whether ApoA5 also impacts ectopic lipid deposition in liver and skeletal muscle, as well as tissue insulin sensitivity, we treated mice with an antisense ...
João Paulo G. Camporez, Shoichi Kanda, Max C. Petersen, François R. Jornayvaz, Varman T. Samuel, Sanjay Bhanot, Kitt Falk Petersen, Michael J. Jurczak, Gerald I. Shulman   +8 more
doaj   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Research advances of correlation between apolipoprotein C3 and diabetes mellitus and diabetic kidney disease

Linchuang shenzangbing zazhi
Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia due to multiple etiological factors. In diabetics, lipid accumulation may cause lipid peroxidation and cell membrane lipid oxidation, leading to cellular injuries and ...
Ling-zhi Li, Xiao-yi Cai, Qi-jun Wan, Xiu-li Zhang   +3 more
doaj   +1 more source

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Archives of Medical Science, 2019
Introduction Psoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance.
Aldona Pietrzak, Paweł Chabros, Ewelina Grywalska, Paweł Kiciński, Kinga Franciszkiewicz-Pietrzak, Dorota Krasowska, Grzegorz Kandzierski   +6 more
doaj   +1 more source

Apolipoprotein A5 and Hypertriglyceridemia [PDF]

Clinical Chemistry, 2005
Hypertriglyceridemia is associated with increased risk of coronary heart disease (CHD) (1)(2)(3)(4)(5), and it is an integral component of the overlapping syndromes of familial combined hyperlipidemia, insulin resistance syndrome, atherogenic lipoprotein profile, and hyperapobetalipoproteinemia (6).
Charlton-Menys, Valentine, Durrington, Paul N.   +1 more
openaire   +2 more sources