Results 31 to 40 of about 2,196 (157)

An apolipoprotein A-I mimetic dose-dependently increases the formation of preβ1 HDL in human plasma

Journal of Lipid Research, 2008
Preβ1 HDL is the initial plasma acceptor of cell-derived cholesterol in reverse cholesterol transport. Recently, small amphipathic peptides composed of D-amino acids have been shown to mimic apolipoprotein A-I (apoA-I) as a precursor for HDL formation ...
Jason S. Troutt, William E. Alborn, Marian K. Mosior, Jiannong Dai, Anthony T. Murphy, Thomas P. Beyer, Youyan Zhang, Guoqing Cao, Robert J. Konrad   +8 more
doaj   +1 more source

The apoA-I mimetic peptide 4F protects apolipoprotein A-I from oxidative damage [PDF]

Chemistry and Physics of Lipids, 2019
High density lipoprotein (HDL) is prone to modification by the oxidizing and chlorinating agent hypochlorite anion (OCl-). Oxidation of apolipoprotein (apo) A-I, the major protein in HDL, reduces ABCA-1 mediated cholesterol efflux and other protective responses to HDL.
C Roger, White, Geeta, Datta, Landon, Wilson, Mayakonda N, Palgunachari, G M, Anantharamaiah   +4 more
openaire   +2 more sources

D-4F-mediated reduction in metabolites of arachidonic and linoleic acids in the small intestine is associated with decreased inflammation in low-density lipoprotein receptor-null mice

Journal of Lipid Research, 2012
To test the hypothesis that intestine is a major site of action for D-4F, LDLR−/− mice were fed a Western diet (WD) and administered the peptide subcutaneously (SQ) or orally.
Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Greg Hough, Georgette M. Buga, Jan Danciger, Alan M. Fogelman   +6 more
doaj   +1 more source

D-4F decreases brain arteriole inflammation and improves cognitive performance in LDL receptor-null mice on a Western diet

Journal of Lipid Research, 2006
LDL receptor-null mice on a Western diet (WD) have inflammation in large arteries and endothelial dysfunction in small arteries, which are improved with the apolipoprotein A-I mimetic D-4F. The role of hyperlipidemia in causing inflammation of very small
Georgette M. Buga, Joy S. Frank, Giuliano A. Mottino, Michael Hendizadeh, Ashkan Hakhamian, Jan H. Tillisch, Srinivasa T. Reddy, Mohamad Navab, G.M. Anantharamaiah, Louis J. Ignarro, Alan M. Fogelman   +10 more
doaj   +1 more source

Transintestinal transport of the anti-inflammatory drug 4F and the modulation of transintestinal cholesterol efflux[S]

Journal of Lipid Research, 2016
The site and mechanism of action of the apoA-I mimetic peptide 4F are incompletely understood. Transintestinal cholesterol efflux (TICE) is a process involved in the clearance of excess cholesterol from the body. While TICE is responsible for at least 30%
David Meriwether, Dawoud Sulaiman, Alan Wagner, Victor Grijalva, Izumi Kaji, Kevin J. Williams, Liqing Yu, Spencer Fogelman, Carmen Volpe, Steven J. Bensinger, G.M. Anantharamaiah, Ishaiahu Shechter, Alan M. Fogelman, Srinivasa T. Reddy   +13 more
doaj   +1 more source

Apolipoprotein-AI mimetic peptides D-4F and L-5F decrease hepatic inflammation and increase insulin sensitivity in C57BL/6 mice.

PLoS ONE, 2020
BACKGROUND:Apolipoprotein-AI (apo-AI) is the major apolipoprotein found in high density lipoprotein particles (HDLs). We previously demonstrated that apo-AI injected directly into high-fat diet fed mice improved insulin sensitivity associated with ...
Kristine C McGrath, Xiaohong Li, Stephen M Twigg, Alison K Heather   +3 more
doaj   +1 more source

D-4F reduces EO6 immunoreactivity, SREBP-1c mRNA levels, and renal inflammation in LDL receptor-null mice fed a Western diet

Journal of Lipid Research, 2008
LDL receptor-null (LDLR−/−) mice on a Western diet (WD) develop endothelial dysfunction and atherosclerosis, which are improved by the apolipoprotein A-I (apoA-I) mimetic peptide D-4F.
Georgette M. Buga, Joy S. Frank, Giuliano A. Mottino, Ashkan Hakhamian, Ajay Narasimha, Andrew D. Watson, Babak Yekta, Mohamad Navab, Srinivasa T. Reddy, G.M. Anantharamaiah, Alan M. Fogelman   +10 more
doaj   +1 more source

Role of enterocyte Enpp2 and autotaxin in regulating lipopolysaccharide levels, systemic inflammation, and atherosclerosis

Journal of Lipid Research, 2023
Conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA) by autotaxin, a secreted phospholipase D, is a major pathway for producing LPA. We previously reported that feeding Ldlr−/− mice standard mouse chow supplemented with unsaturated LPA or
Arnab Chattopadhyay, Pallavi Mukherjee, Dawoud Sulaiman, Huan Wang, Victor Girjalva, Nasrin Dorreh, Jonathan P. Jacobs, Samuel Delk, Wouter H. Moolenaar, Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman   +11 more
doaj   +1 more source

Enhancement by LDL of transfer of L-4F and oxidized lipids to HDL in C57BL/6J mice and human plasma

Journal of Lipid Research, 2011
The apoA-I mimetic peptide L-4F [(Ac-D-W-F-K-A-F-Y-D-K-V-A-E-K-F-K-E-A-F-NH2) synthesized from all L-amino acids] has shown potential for the treatment of a variety of diseases. Here, we demonstrate that LDL promotes association between L-4F and HDL. A 2-
David Meriwether, Satoshi Imaizumi, Victor Grijalva, Greg Hough, Ladan Vakili, G.M. Anantharamaiah, Robin Farias-Eisner, Mohamad Navab, Alan M. Fogelman, Srinivasa T. Reddy, Ishaiahu Shechter   +10 more
doaj   +1 more source

Apolipoprotein A-I mimetic peptide 4F blocks sphingomyelinase-induced LDL aggregation [PDF]

Journal of Lipid Research, 2015
Lipolytic modification of LDL particles by SMase generates LDL aggregates with a strong affinity for human arterial proteoglycans and may so enhance LDL retention in the arterial wall. Here, we evaluated the effects of apoA-I mimetic peptide 4F on structural and functional properties of the SMase-modified LDL particles.
Su Duy Nguyen, Matti Javanainen, Sami Rissanen, Hongxia Zhao, Jenni Huusko, Annukka M. Kivelä, Seppo Ylä-Herttuala, Mohamad Navab, Alan M. Fogelman, Ilpo Vattulainen, Petri T. Kovanen, Katariina Öörni   +11 more
openaire   +5 more sources