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Apolipoprotein C-II Deficiency Revisited

New England Journal of Medicine, 1984
In 1978, Breckenridge et al. described a patient with a deficiency of apolipoprotein C-II, the activator of the enzyme lipoprotein lipase.1 It was predicted that the newly discovered disorder would...
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Electrophoretic screening for human apolipoprotein C-II variants: repeated identification of apolipoprotein C-II(K19T)

Journal of Molecular Medicine, 1995
Screening for apolipoprotein (apo) C-II variants in the plasma of 400 students, 600 patients of a cardiological rehabilitation center, and 1200 patients of an outpatient lipid clinic by isoelectric focusing and subsequent anti-apo C-II immunoblotting led to the identification of four individuals whose plasma samples contained an apo C-II isoform with ...
H, Wiebusch   +7 more
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Plasma apolipoprotein concentrations in familial apolipoprotein A-I and A-II deficiency (Tangier disease)

Metabolism, 1981
Familial apolipoprotein A-I and A-II deficiency (Tangier disease) is characterized by cholesterol ester deposition in histiocytes, decreased plasma cholesterol and low density lipoprotein cholesterol (C-LDL), and a striking deficiency of high density lipoproteins (HDL).
P, Alaupovic   +4 more
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Kinetics of apolipoproteins A-I and A-II

1984
Plasma lipoproteins are a polydisperse collection of particles which range in diameter from 7 to 160 nm. These lipoproteins particles have been classified according to methods of separation1. One system, based on density, divides the lipoproteins into five classes: chylomicrons (ρ < 0.95), very-low-density lipoproteins (VLDL, 0.95 < ρ < 1.006 ...
L. Zech   +4 more
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THE DEVELOPMENT OF AN ELISA FOR CHICKEN APOLIPOPROTEIN II QUANTITATION

Journal of Immunoassay and Immunochemistry, 2002
Polyclonal antibodies raised against chicken apoll was characterised for its use in Western blotting and ELISA detection systems of apoll in chicken plasma. The antibody has a high avidity and specificity for apolipoprotein II (apoII). Western blots show that the antibody reacts with a single band at 15 kDa.
Pool EJ   +4 more
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Apolipoprotein A-II accelerates reactive AA amyloidosis

Amyloid, 2017
During the acute-phase response (APR), there is a dramatic increase in serum amyloid A (SAA) circulating in the blood in high-density lipoproteins (HDL).
Mu, Yang   +8 more
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Hypertriglyceridemia Associated with Deficiency of Apolipoprotein C-II

New England Journal of Medicine, 1978
A 59-year-old man with severe hypertriglyceridemia and no post-heparin lipolytic activity was studied because of a marked fall in plasma triglyceride concentrations after a blood transfusion. An apolipoprotein activator (apolipoprotein C-II) for lipoprotein lipase could not be detected by polyacrylamide-gel electrophoresis of apoproteins ...
W C, Breckenridge   +4 more
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Plasma, apolipoprotein A‐I and A‐II levels in hyperlipidemia

Lipids, 1978
AbstractSome of the component moieties of high denisty lipoproteins (HDL) were analyzed in normal subjects and in patients with hyperlipidemia. Apoproteins A‐I and A‐II were quantified by radioimmunoassay, HDL cholesterol and triglycerides were assessed on heparin‐MnCl2 supernates of fasting plasmas.
G, Schonfeld, A, Bailey, R, Steelman
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A neonatal case of apolipoprotein C-II deficiency

European Journal of Pediatrics, 1989
A neonatal case of apo C-II deficiency with hypertriglyceridaemia and xanthomas is presented. The patient responded well to a special diet formula containing medium-chain triglycerides (MCT). This is the first case of apo C-II deficiency to be discovered during the neonatal period.
M, Ohno   +8 more
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Atherosclerosis in Transgenic Mice Overexpressing Apolipoprotein A-II

Science, 1993
Concentrations of plasma high density lipoprotein (HDL) are inversely correlated with atherosclerotic coronary artery disease. The two most abundant protein constituents of HDL are apolipoproteins A-I and A-II (apoA-I and apoA-II). ApoA-I is required for assembly of HDL and, when overexpressed in transgenic mice, confers resistance to early ...
C H, Warden   +4 more
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