Results 41 to 50 of about 23,930 (202)

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Relationship between Apolipoprotein Superfamily and Parkinson's Disease

Chinese Medical Journal, 2017
Objective: Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life.
Lin Li, Ming-Su Liu, Guang-Qin Li, Jie Tang, Yan Liao, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan   +8 more
doaj   +1 more source

Cross-sectional and longitudinal associations of apolipoprotein A1 and B with glycosylated hemoglobin in Chinese adults

Scientific Reports, 2022
Apolipoproteins exert a key role on glucose metabolism; however, scarce data have examined the relationship between apolipoproteins and glycated haemoglobin (HbA1c) in Chinese adults.
Hongli Dong, Wenqing Ni, Yamin Bai, Xueli Yuan, Yan Zhang, Hongmin Zhang, Yuanying Sun, Jian Xu   +7 more
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation

Lipids in Health and Disease, 2019
Background Hypocholesterolemia is the most frequently encountered lipid abnormality in sickle cell disease (SCD). We enrolled pediatric patients to determine the relationships between lipid profile and parameters of hemolysis, oxidative stress and ...
Ahmet Yalcinkaya, Selma Unal, Yesim Oztas   +2 more
doaj   +1 more source

Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level

Journal of Community Hospital Internal Medicine Perspectives, 2021
Introduction 25-Hydroxy vitamin D (Vit D3) deficiency was found to be associated with vascular dysfunction, arterial stiffening, extent of coronary artery disease and cardiovascular mortality.
Cyrus Elmi, Melton Mingtian Fan, Marjolein Le, Gang Cheng, Koroush Khalighi   +4 more
doaj   +1 more source

Genetic Modifiers of ABCA1 Activity Interact with APOE Isoforms to Mediate Alzheimer's Disease Risk

Annals of Neurology, EarlyView.
Objective ATP‐binding cassette transporter A1 (ABCA1) has been associated with Alzheimer's disease (AD), but the mechanisms by which it impacts disease risk are unknown. ABCA1 is known to bind apolipoprotein E (ApoE) and catalyze apolipoprotein lipidation.
Andrés Peña‐Tauber, Ricardo Hernández Arriaza, Dylan Reil, Manon Muntaner, Junyoung Park, Benjamin Grenier‐Boley, Marc Hulsman, Philippe Amouyel, Céline Bellenguez, Camille Charbonnier, Jean‐François Deleuze, Orio Dols‐Icardo, John Hardy, Henne Holstege, Gaël Nicolas, Simon Mead, Michael Wagner, Alfredo Ramirez, Rebecca Sims, John van Swieten, Julie Willams, Jean‐Charles Lambert, Chaitan Khosla, Yann Le Guen, Michael D Greicius   +24 more
wiley   +1 more source

An abundant dysfunctional apolipoprotein A1 in human atheroma [PDF]

Nature Medicine, 2014
Recent studies have indicated that high-density lipoproteins (HDLs) and their major structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are dysfunctional and are extensively oxidized by myeloperoxidase (MPO). In vitro oxidation of either apoA1 or HDL particles by MPO impairs their cholesterol acceptor function.
Huang, Ying, DiDonato, Joseph A., Levison, Bruce S., Schmitt, Dave, Li, Lin, Wu, Yuping, Buffa, Jennifer, Kim, Timothy, Gerstenecker, Gary, Gu, Xiaodong, Kadiyala, Chandra, Wang, Zeneng, Culley, Miranda K., Hazen, Jennie E., DiDonato, Anthony J., Fu, Xiaoming, Berisha, Stela, Peng, Daoquan, Nguyen, Truc, Liang, Shaohong, Chuang, Chia-Chi, Cho, Leslie, Plow, Edward F., Fox, Paul L., Gogonea, Valentin, Tang, W.H. Wilson, Parks, John S., Fisher, Edward A., Smith, Jonathan D., Hazen, Stanley L.   +29 more
openaire   +2 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Plasma apolipoprotein A1 as a biomarker for Parkinson disease [PDF]

Annals of Neurology, 2013
Objective To identify plasma‐based biomarkers for Parkinson disease (PD) risk. Methods In a discovery cohort of 152 PD patients, plasma levels of 96 proteins were measured by multiplex immunoassay; proteins associated with age at PD ...
Judy K, Qiang, Yvette C, Wong, Andrew, Siderowf, Howard I, Hurtig, Sharon X, Xie, Virginia M-Y, Lee, John Q, Trojanowski, Dora, Yearout, James, B Leverenz, Thomas J, Montine, Matt, Stern, Susan, Mendick, Danna, Jennings, Cyrus, Zabetian, Ken, Marek, Alice S, Chen-Plotkin   +15 more
openaire   +2 more sources