Results 41 to 50 of about 23,783 (200)

Functional Blood‐Brain Barrier Crossing by Biomimetic M13 Phage Vectors for Targeted Neuronal Delivery

Advanced Healthcare Materials, EarlyView.
This study investigates the M13 bacteriophage as a biomimetic nanovector capable of crossing in vitro models of the blood–brain barrier. By exploiting peculiar transcellular pathways, M13 avoids lysosomal degradation and preserves its structural integrity and functionality.
Silvia Vercellino, Lucia Pappagallo, Francesca De Chirico, Luca Boselli, Hazem Ahmed, Luca Spagnoletti, Giovanni Pittaluga, Paolo Emidio Costantini, Matteo Calvaresi, Pier Paolo Pompa, Alberto Danielli, Fabio Benfenati, Valentina Castagnola   +12 more
wiley   +1 more source

The association between blood lipids and cognitive impairment in type 2 diabetes mellitus

European Journal of Medical Research
Objective The study was performed to explore the association between blood lipids and cognitive impairment in patients with type 2 diabetes mellitus (T2DM). Methods This study included 336 patients with T2DM.
Li Ma, Yue-Xing Yuan, Feng-Jin Cheng, Yan Liu, Qiong Wei, You-Fan Peng, Yao Wang   +6 more
doaj   +1 more source

Relationship between Apolipoprotein Superfamily and Parkinson's Disease

Chinese Medical Journal, 2017
Objective: Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life.
Lin Li, Ming-Su Liu, Guang-Qin Li, Jie Tang, Yan Liao, Yang Zheng, Tong-Li Guo, Xin Kang, Mao-Ting Yuan   +8 more
doaj   +1 more source

Cross-sectional and longitudinal associations of apolipoprotein A1 and B with glycosylated hemoglobin in Chinese adults

Scientific Reports, 2022
Apolipoproteins exert a key role on glucose metabolism; however, scarce data have examined the relationship between apolipoproteins and glycated haemoglobin (HbA1c) in Chinese adults.
Hongli Dong, Wenqing Ni, Yamin Bai, Xueli Yuan, Yan Zhang, Hongmin Zhang, Yuanying Sun, Jian Xu   +7 more
doaj   +1 more source

Plasma apolipoprotein A1 as a biomarker for Parkinson disease [PDF]

Annals of Neurology, 2013
Objective To identify plasma‐based biomarkers for Parkinson disease (PD) risk. Methods In a discovery cohort of 152 PD patients, plasma levels of 96 proteins were measured by multiplex immunoassay; proteins associated with age at PD ...
Judy K, Qiang, Yvette C, Wong, Andrew, Siderowf, Howard I, Hurtig, Sharon X, Xie, Virginia M-Y, Lee, John Q, Trojanowski, Dora, Yearout, James, B Leverenz, Thomas J, Montine, Matt, Stern, Susan, Mendick, Danna, Jennings, Cyrus, Zabetian, Ken, Marek, Alice S, Chen-Plotkin   +15 more
openaire   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Altered HDL particle in sickle cell disease: decreased cholesterol content is associated with hemolysis, whereas decreased Apolipoprotein A1 is linked to inflammation

Lipids in Health and Disease, 2019
Background Hypocholesterolemia is the most frequently encountered lipid abnormality in sickle cell disease (SCD). We enrolled pediatric patients to determine the relationships between lipid profile and parameters of hemolysis, oxidative stress and ...
Ahmet Yalcinkaya, Selma Unal, Yesim Oztas   +2 more
doaj   +1 more source

Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level

Journal of Community Hospital Internal Medicine Perspectives, 2021
Introduction 25-Hydroxy vitamin D (Vit D3) deficiency was found to be associated with vascular dysfunction, arterial stiffening, extent of coronary artery disease and cardiovascular mortality.
Cyrus Elmi, Melton Mingtian Fan, Marjolein Le, Gang Cheng, Koroush Khalighi   +4 more
doaj   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Associations of iron status with apolipoproteins and lipid ratios: a cross-sectional study from the China Health and Nutrition Survey

Lipids in Health and Disease, 2020
Background Iron overload has been found to be related with various cardiometabolic disorders, like dyslipidemia, metabolic syndrome, and diabetes.
Bowen Zhou, Huihui Ren, Xinrong Zhou, Gang Yuan   +3 more
doaj   +1 more source