Results 31 to 40 of about 634,093 (256)

Effects of lipid-lowering agents on plasma lipid profile and apolipoprotein B in patients with type 2 diabetes mellitus [PDF]

, 2021
Objectives: Type 2 Diabetes Mellitus (T2DM) accounts for about 90% of all cases of Diabetes Mellitus. Dyslipidaemia has been demonstrated to form a synergy with T2DM as risk factors for cardiovascular events.
Adekoya, A.O., Adesegun, O.A., Amballi, A.A., Amusan, O.O., Ebesunun, M.O., Ehioghae, O., Idowu, A.A., Idowu, A.O., Taiwo, F., Uka, A.   +9 more
core   +2 more sources

Ferritin heavy chain Is the host factor responsible for HCV-Induced inhibition of apoB-100 production and is required for efficient viral infection [PDF]

, 2012
Hepatic fat export occurs by apolipoprotein B-100-containing lipoprotein production, whereas impaired production leads to liver steatosis. Hepatitis C virus (HCV) infection is associated to dysregulation of apoB-100 secretion and steatosis; however, the ...
AMICONE, Laura, Claudia Montaldo, Cristina Di Giacomo, Giuseppe Ippolito, Laura Santangelo, Leopoldo Paolo Pucillo, MANCONE, Carmine, Tonino Alonzi, TRIPODI, Marco, Viviana Costa   +9 more
core   +3 more sources

Mipomersen, an Apolipoprotein B Synthesis Inhibitor, Reduces Atherogenic Lipoproteins in Patients With Severe Hypercholesterolemia at High Cardiovascular Risk A Randomized, Double-Blind, Placebo-Controlled Trial [PDF]

, 2013
ObjectivesThis study sought to examine the efficacy and safety of mipomersen for reducing atherogenic lipids and lipoproteins in patients with hypercholesterolemia.BackgroundMany patients on lipid-lowering therapies remain unable to achieve target low ...
Ali, Shariq, Chin, Wai, Cromwell, William C., Davidson, Michael, Flaim, JoAnn D., Thomas, Gregory S.   +5 more
core   +1 more source

Familial defective apolipoprotein B-100: low density lipoproteins with abnormal receptor binding.

Proceedings of the National Academy of Sciences of the United States of America, 1987
Previous in vivo turnover studies suggested that retarded clearance of low density lipoproteins (LDL) from the plasma of some hypercholesterolemic patients is due to LDL with defective receptor binding.
T. Innerarity, K. Weisgraber, K. Arnold, R. Mahley, Ronald M. Krauss, G. L. Vega, Scott M. Grundy   +6 more
semanticscholar   +1 more source

Decreased VLDL-Apo B 100 fractional synthesis rate despite hypertriglyceridemia in subjects with type 2 diabetes and nephropathy [PDF]

, 2015
Subjects with Type 2 Diabetes Mellitus (T2DM) and diabetic nephropathy (DN) often exhibit hypertriglyceridemia. The mechanism(s) of such an increase are poorly known. OBJECTIVE: We investigated VLDL-Apo B 100 kinetics in T2DM subjects with and without DN,
Barazzoni, Rocco, Cortella, Irene, Gabelli, Carlo, Kiwanuka, Edward, Manesso, Erica, Pasqualetto, Gloria, Puricelli, Lucia, Tessari, Paolo, Toffolo, Gianna M, Vettore, Monica, Zanetti, Michela   +10 more
core   +1 more source

Reduced hippocampal volume in healthy young ApoE4 carriers: an MRI study. [PDF]

, 2012
The E4 allele of the ApoE gene has consistently been shown to be related to an increased risk of Alzheimer's disease (AD). The E4 allele is also associated with functional and structural grey matter (GM) changes in healthy young, middle-aged and older ...
Hampel, Harald, Lamberton, Franck, Matura, Silke, Miller, Julia, O'Dwyer, Laurence, Prvulovic, David, Rujescu, Dan, Scheibe, Monika, Tanner, Colby   +8 more
core   +7 more sources

Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100.

Proceedings of the National Academy of Sciences of the United States of America, 1989
Familial defective apolipoprotein (apo) B-100 is a genetic disease that leads to hypercholesterolemia and to an increased serum concentration of low density lipoproteins that bind defectively to the apoB,E(LDL) receptor.
Luis F. Soria, E. Ludwig, H. R. Clarke, Gloria L. VEGAt, Scott M. Grundyt, B. Mccarthy   +5 more
semanticscholar   +1 more source

The secondary structure of apolipoprotein A-I on 9.6-nm reconstituted high-density lipoprotein determined by EPR spectroscopy. [PDF]

, 2013
Apolipoprotein A-I (ApoA-I) is the major protein component of high-density lipoprotein (HDL), and is critical for maintenance of cholesterol homeostasis.
Borja, Mark S, Budamagunta, Madhu S, Lagerstedt, Jens O, Oda, Michael N, Petrlova, Jitka, Voss, John C   +5 more
core   +1 more source

Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts) [PDF]

, 2005
Apolipoprotein E (apoE) is a multifunctional circulating 34-kDa protein, whose gene encodes single-nucleotide polymorphisms linked to several neurodegenerative diseases.
Dickson, JG, Owen, JS, Simons, JP, Tagalakis, AD   +3 more
core   +1 more source

Familial Defective Apolipoprotein B-100 in 12 Subjects and Their Kindred [PDF]

Clinical Chemistry and Laboratory Medicine, 1992
Twelve unrelated subjects with heterozygous familial defective apolipoprotein B-100 were identified in a group of 252 patients with type IIa hypercholesterolaemia. Approximately 5% of hypercholesterolaemia can be explained by this mutation in the collective studied.
Geisel, J., Schleifenbaum, T., Oette, K., Weisshaar, Bernd   +3 more
openaire   +4 more sources