Results 51 to 60 of about 623 (213)

Chaotropic Surface Arginine Correlates With Protein Corona Formation on Anti‐Fouling Biomaterial Surfaces: A Quantitative Proteomics and Protein Structure Study

Advanced Materials Interfaces, EarlyView.
Why do specific proteins accumulate on “non‐fouling” surfaces? Quantitative proteomics and structural analysis reveal surface‐exposed arginine as the key molecular determinant. ABSTRACT The protein corona determines the biocompatibility of medical devices, yet predicting its composition on anti‐fouling surfaces remains challenging.
Ayano Nomura, Guanghao Hu, Ang Art Wei Yao, Chisato Komura, Hideharu Kurioka, Tomohiro Hayashi   +5 more
wiley   +1 more source

Asymmetric distribution of pause transfer sequences in apolipoprotein B-100

Journal of Lipid Research, 1997
Lipoprotein assembly requires a complex and regulated set of events that includes apolipoprotein B (apoB) translocation across the endoplasmic reticulum (ER) membrane, folding, and association with lipids.
M H Kivlen, C A Dorsey, V R Lingappa, R S Hegde   +3 more
doaj   +1 more source

Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Thrombin cleavage of apolipoprotein Bh of rabbit LDL: structural comparisons with human apolipoprotein B-100.

Journal of Lipid Research, 1992
Rabbit plasma low density lipoprotein (LDL) contains one major apolipoprotein of apparent molecular weight of 320 kDa, designated apolipoprotein (apo) Bh, while another component termed apoB1 of apparent molecular weight of 220 kDa is found in ...
A Leroy, G Castro, G Agnani, R Saïle, A Barkia, JC Fruchart   +5 more
doaj   +1 more source

Determination of the molecular mass of apolipoprotein B-100 A chemical approach [PDF]

Biochemical Journal, 1986
Apolipoprotein B-100 (apo B-100) is the protein ligand in low-density lipoproteins that binds to a specific cell-surface receptor. Its molecular mass has been a subject of controversy. We have determined the molecular mass of the protein by a chemical approach.
C Y, Yang, F S, Lee, L, Chan, D A, Sparrow, J T, Sparrow, A M, Gotto   +5 more
openaire   +2 more sources

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Effect of urotensin II on apolipoprotein B 100 and apolipoprotein A-I expression in HepG2 cell line

Advanced Biomedical Research, 2014
Background: Increased apolipoprotein B100 (apo B) and decreased apolipoprotein A-I (apo A-I) production are important risk factors in atherosclerosis.
Abbas Mohammadi, Ahmad Gholamhoseinian Najar, Amirhosein Khoshi   +2 more
doaj   +1 more source

Human Placenta Secretes Apolipoprotein B-100-containing Lipoproteins [PDF]

Journal of Biological Chemistry, 2004
Supply of lipids from the mother is essential for fetal growth and development. In mice, disruption of yolk sac cell secretion of apolipoprotein (apo) B-containing lipoproteins results in embryonic lethality. In humans, the yolk sac is vestigial. Nutritional functions are instead established very early during pregnancy in the placenta.
Munk-Madsen, Eva, Lindegaard, Marie Louise Skakkebæk, Andersen, Claus B, Damm, Peter, Nielsen, Lars B   +4 more
openaire   +3 more sources

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source