Results 1 to 10 of about 207,429 (294)

Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content [PDF]

Journal of Lipid Research
Apolipoprotein A-V (APOA5) is a critical regulator of circulating triglyceride (TG) levels. Its deletion leads to elevated plasma TG concentrations by altering the metabolism of VLDL particles in vivo.
Pheruza Tarapore, Debi Swertfeger, Jamie Morris, Yi He, Snigdha Sarkar, John T. Melchior, Amy S. Shah, Min Liu, W. Sean Davidson   +8 more
doaj   +2 more sources

Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]

Journal of Integrative Neuroscience, 2021
Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing, Tao Meng, Joseph Therriault, Jing Luo, Hua Zhang, Alzheimer’s Disease Neuroimaging Initiative   +5 more
doaj   +1 more source

LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit [PDF]

, 2012
Apolipoprotein A-I and Apolipoprotein E promote different steps of reverse cholesterol transport, including lecithin-cholesterol acyltransferase stimulation.
A. Carlucci, B. Maresca, G. Di Salvo, L. Cigliano, M. S. Spagnuolo, P. Abrescia, R. Calabrò   +6 more
core   +3 more sources

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Annals of General Psychiatry, 2021
Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of ...
Wenwang Rao, Xiangfei Meng, Keqing Li, Yunshu Zhang, Xiang Yang Zhang   +4 more
doaj   +1 more source

TREM2 coding variants in Slovak Alzheimer's disease patients

Journal of Integrative Neuroscience, 2022
Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of ...
Vladimira Durmanova, Juraj Javor, Zuzana Parnicka, Gabriel Minarik, Agata Ocenasova, Barbora Vaseckova, Iliana Kiralyova, Stanislav Sutovsky, Robert Petrovic, Ivana Shawkatova   +9 more
doaj   +1 more source

Semisynthesis and segmental isotope labeling of the apoE3 N-terminal domain using expressed protein ligation

Journal of Lipid Research, 2009
Apolipoprotein E (apoE) is an exchangeable apolipoprotein that functions as a ligand for members of the LDL receptor family, promoting lipoprotein clearance from the circulation. Productive receptor binding requires that apoE adopt an LDL receptor-active
Paul S. Hauser, Vincent Raussens, Taichi Yamamoto, Gezman E. Abdullahi, Paul M.M. Weers, Brian D. Sykes, Robert O. Ryan   +6 more
doaj   +1 more source

Association of apolipoprotein ε4 allele with intellectual disability in children with cerebral palsy

Archives of Mental Health, 2023
Background: The apolipoprotein E (ApoE) protein is the most essential lipid transporter in the brain which is vital in neurodevelopment. The production of ApoE is regulated by several genes and increases under certain conditions such as cerebral injury.
N Sreedevi, N Swapna, Santosh Maruthy, Rajesh Kundapur, Charles Sylvester   +4 more
doaj   +1 more source

Similar promotion of Aβ_1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms

Journal of Neuroinflammation, 2004
The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D, LeVine Harry, Martins Ralph, Sweeney David, Gandy Sam   +4 more
doaj   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
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core   +1 more source

Apolipoprotein E is secreted by cultured lipocytes of the rat liver.

Journal of Lipid Research, 1991
Hepatic lipocytes, the retinoid-storing cells of the liver, share several characteristics with vascular smooth muscle cells. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA ...
G Friedman, LM Liu, SL Friedman, JK Boyles   +3 more
doaj   +1 more source