Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content [PDF]
Journal of Lipid ResearchApolipoprotein A-V (APOA5) is a critical regulator of circulating triglyceride (TG) levels. Its deletion leads to elevated plasma TG concentrations by altering the metabolism of VLDL particles in vivo.
Pheruza Tarapore +8 more
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Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]
Journal of Integrative Neuroscience, 2021 Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing +5 more
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TREM2 coding variants in Slovak Alzheimer's disease patients
Journal of Integrative Neuroscience, 2022 Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of ...
Vladimira Durmanova +9 more
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Heterozygous transferrin receptor 1 deletion reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. [PDF]
Atheroscler PlusNaito Y +3 more
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White matter differences between healthy young ApoE4 carriers and non-carriers identified with tractography and support vector machines. [PDF]
, 2012 The apolipoprotein E4 (ApoE4) is an established risk factor for Alzheimer's disease (AD). Previous work has shown that this allele is associated with functional (fMRI) changes as well structural grey matter (GM) changes in healthy young, middle-aged and ...
Hampel, Harald +7 more
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LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit [PDF]
, 2011 Apolipoprotein A-I and Apolipoprotein E promote different steps of reverse cholesterol transport, including lecithin-cholesterol acyltransferase stimulation.
A. Carlucci +6 more
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Association of apolipoprotein ε4 allele with intellectual disability in children with cerebral palsy
Archives of Mental Health, 2023 Background: The apolipoprotein E (ApoE) protein is the most essential lipid transporter in the brain which is vital in neurodevelopment. The production of ApoE is regulated by several genes and increases under certain conditions such as cerebral injury.
N Sreedevi +4 more
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Journal of Lipid Research, 2009 Apolipoprotein E (apoE) is an exchangeable apolipoprotein that functions as a ligand for members of the LDL receptor family, promoting lipoprotein clearance from the circulation. Productive receptor binding requires that apoE adopt an LDL receptor-active
Paul S. Hauser +6 more
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Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity
Biomolecules, 2020 Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease.
Anna L. Gharibyan +9 more
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Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Journal of Neuroinflammation, 2004 The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D +4 more
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