Results 1 to 10 of about 334,081 (324)
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]
Journal of Integrative Neuroscience, 2021 Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing +5 more
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Apolipoprotein E and Alzheimer's Disease [PDF]
Annual Review of Neuroscience, 1995 The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrasL the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant
Allen D. Roses, Warren J. Strittmatter
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Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Atherosclerosis is still the leading cause of death in Western world. Development of atherosclerotic plaque involves accumulation of inflammatory cells, lipids, smooth muscle cells and extracellular matrix proteins in the intima ...
Zurnić Irena +5 more
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Annals of General Psychiatry, 2021 Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of ...
Wenwang Rao +4 more
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Apolipoprotein E and Alzheimer's disease
Acta Pharmaceutica Sinica B, 2022 Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk is dose dependent, as those carrying one APOE ε4 allele have a 2-3-fold increased risk, while those carrying two ε4 alleles have a 10-15-fold increased risk.
Benjamin R. Troutwine +4 more
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Apolipoprotein £ and Epilepsy [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1996 The overall frequencies of the apolipoprotein f2, f3 and f4 alleles in the epilepsy patients were no different to those of the control group (Table 1). Subgroups consisting of patients with either an unknown aetiology for epilepsy (71% of patients), a family history of epilepsy (21% of patients), idiopathic generalized epilepsy, or cryptogenic partial ...
Eric S Kilpatrick +3 more
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Indian Journal of Dermatology, 2023 Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities.
Amany I Mustafa +5 more
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Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Journal of Neuroinflammation, 2004 The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D +4 more
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Apolipoprotein E and familial longevity [PDF]
Neurobiology of Aging, 2013 Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently.
Sandra Barral +9 more
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African Journal of Laboratory Medicine, 2023 Background: Dyslipidaemia is a known cause of cardiovascular mortality. Persons living with HIV are at high risk of developing cardiovascular disease due to lipid metabolism disorders associated with HIV or its therapy.
Mercy N. Okunorobo +3 more
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