Results 1 to 10 of about 194,689 (341)
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]
Journal of Integrative Neuroscience, 2021 Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing +5 more
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TREM2 coding variants in Slovak Alzheimer's disease patients
Journal of Integrative Neuroscience, 2022 Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of ...
Vladimira Durmanova +9 more
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Apolipoprotein E and Alzheimer's Disease [PDF]
Annual Review of Neuroscience, 1995 The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrasL the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant
Allen D. Roses, Warren J. Strittmatter
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Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Atherosclerosis is still the leading cause of death in Western world. Development of atherosclerotic plaque involves accumulation of inflammatory cells, lipids, smooth muscle cells and extracellular matrix proteins in the intima ...
Zurnić Irena +5 more
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Association of apolipoprotein ε4 allele with intellectual disability in children with cerebral palsy
Archives of Mental Health, 2023 Background: The apolipoprotein E (ApoE) protein is the most essential lipid transporter in the brain which is vital in neurodevelopment. The production of ApoE is regulated by several genes and increases under certain conditions such as cerebral injury.
N Sreedevi +4 more
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Apolipoprotein E and Alzheimer's disease
Acta Pharmaceutica Sinica B, 2022 Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk is dose dependent, as those carrying one APOE ε4 allele have a 2-3-fold increased risk, while those carrying two ε4 alleles have a 10-15-fold increased risk.
Benjamin R. Troutwine +4 more
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Apolipoprotein £ and Epilepsy [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1996 The overall frequencies of the apolipoprotein f2, f3 and f4 alleles in the epilepsy patients were no different to those of the control group (Table 1). Subgroups consisting of patients with either an unknown aetiology for epilepsy (71% of patients), a family history of epilepsy (21% of patients), idiopathic generalized epilepsy, or cryptogenic partial ...
Eric S Kilpatrick +3 more
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Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Journal of Neuroinflammation, 2004 The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D +4 more
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Apolipoprotein E and familial longevity [PDF]
Neurobiology of Aging, 2013 Exceptional longevity is associated with substantial heritability. The ε4 allele in apolipoprotein E and the linked G allele in rs2075650 of TOMM40 have been associated with increased mortality and the ε2 allele with decreased mortality, although inconsistently.
Sandra Barral +9 more
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Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders [PDF]
Archives of Razi Institute, 2022 Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals,
A Gasmi, A Menzel, S Piscopo, S Noor
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