On the mathematical origin of quantum space-time [PDF]
arXiv, 2007 An Euclidean topological space E is homeomorphic to the subset of delta-functions of the space D'(E) of Schwartz distributions on E. Herewith, any smooth function of compact support on E is extended onto D'(E). One can think of these extensions as sue generis quantum deformations. In quantum models, one therefore should replace integration of functions
arxiv
Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis
Neuron, 2020 Yun Chen +3 more
semanticscholar +1 more source
Comparative proteome analysis of the ligamentum flavum of patients with lumbar spinal canal stenosis
JOR SPINE, Volume 5, Issue 4, December 2022., 2022 This study investigated the pathology of thickened ligamentum flavum in patients with lumbar spinal canal stenosis (LSCS) based on protein expression levels using shotgun proteome analysis. The results showed that tissue repair via fibrosis, chondrometaplasia, and amyloid deposits may be important pathologies that occur in the thickened ligamentum ...
Yutaka Yabe +8 more
wiley +1 more source
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Nature Reviews Neurology, 2013 Chia-Chen Liu +3 more
semanticscholar +1 more source
Nucleotide sequence of the cynomolgus monkey apolipoprotein E cDNA [PDF]
, 1989 K.R. Marotti +4 more
openalex +1 more source
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Cancer Communications, EarlyView.Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan +13 more
wiley +1 more source
Current Medicine Research and PracticeBackground: Apolipoprotein Ɛ4 has been established as a risk factor for cognitive impairment and dementia among Caucasians; however, the relationship among Black Africans has not been consistent.
Isyaku Gwarzo Mukhtar +4 more
doaj +1 more source
Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition
Chemistry &Biodiversity, Accepted Article.Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb +5 more
wiley +1 more source
Lipid Metabolism and Immune Function: Chemical Tools for Insights into T‐Cell Biology
ChemBioChem, EarlyView.This review explores how lipids regulate immune responses, particularly in T‐cell function. Advances in metabolomics and proteomics provide insights into lipid‐mediated immunity. Fluorescent lipids enable single‐cell analysis of lipid uptake and metabolism.
Luuk Reinalda +2 more
wiley +1 more source
Modeling Interconnected Modules in Multivariate Outcomes: Evaluating the Impact of Alcohol Intake on Plasma Metabolomics [PDF]
arXivAlcohol consumption has been shown to influence cardiovascular mechanisms in humans, leading to observable alterations in the plasma metabolomic profile. Regression models are commonly employed to investigate these effects, treating metabolomics features as the outcomes and alcohol intake as the exposure. Given the latent dependence structure among the
arxiv