Results 171 to 180 of about 195,708 (344)
ABSTRACT Objective Possible pleiotropic effects of apolipoprotein E4 (APOE E4) in individuals with congenital brain malformations are relatively unknown. Our goal was to determine if neurodegeneration‐linked brain region volumes differ significantly between E4 carriers and noncarriers in young adults with spina bifida (SB). Methods Eleven individuals (
Joan M. Jasien+8 more
wiley +1 more source
Human apolipoprotein E mRNA. cDNA cloning and nucleotide sequencing of a new variant.
J W McLean+4 more
openalex +1 more source
Apolipoprotein E polymorphism and heterozygous familial hypercholesterolemia. Sex-specific effects. [PDF]
Jean Ferrières+4 more
openalex +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou+6 more
wiley +1 more source
Role of selenium in the pathophysiology of cardiorenal anaemia syndrome
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai+2 more
wiley +1 more source
Serum heat inactivation diminishes ApoE-mediated uptake of D-Lin-MC3-DMA lipid nanoparticles
Nanoparticles play a crucial role in drug delivery research. The protein corona that develops on the surface of nanoparticles after administration has garnered substantial attention due to the significant effects it has on their performance.
Demian van Straten+4 more
doaj +1 more source
A phenomap of TTR amyloidosis to aid diagnostic screening
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos+4 more
wiley +1 more source
Abstract Large clinical data underscore that heart failure is independently associated to an increased risk of negative cognitive outcome and dementia. Emerging evidence suggests that cerebral hypoperfusion, stemming from reduced cardiac output and vascular pathology, may contribute to the largely overlapping vascular dementia and Alzheimer's disease ...
Mauro Massussi+6 more
wiley +1 more source
Abstract We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) evaluating the efficacy of levetiracetam (LEV) compared to placebo in improving cognitive performance in people with cognitive decline. The protocol was pre‐registered with PROSPERO (CRD420250656389) and reporting followed PRISMA guidelines.
Claudia Faini+2 more
wiley +1 more source