Results 11 to 20 of about 334,081 (324)
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders [PDF]
Archives of Razi Institute, 2022 Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals,
A Gasmi, A Menzel, S Piscopo, S Noor
doaj +1 more source
Relationship between Apolipoprotein Superfamily and Parkinson's Disease
Chinese Medical Journal, 2017 Objective: Parkinson's disease (PD) is featured with motor disorder and nonmotor manifestations including psychological symptoms, autonomic nervous system dysfunction, and paresthesia, which results in great inconvenience to the patients' life.
Lin Li +8 more
doaj +1 more source
Apolipoprotein E polymorphism in a Romanian population
Romanian Journal of Cardiology, 2023 Background: Apolipoprotein E (ApoE) is a ubiquitous protein involved in maintaining cholesterol homeostasis and lipoprotein clearance from circulation. It is coded by three alleles (ε2, ε3, ε4) with six genotypes (ε3/ε3, ε3/ε4, ε2/ε3, ε4/ε4, ε2/ε4, and ...
Diaconu Rodica +8 more
doaj +1 more source
Apolipoprotein E and renal disease [PDF]
American Journal of Kidney Diseases, 2004 Apolipoprotein E (ApoE) is a major constituent of plasma lipoproteins with many biological actions of great significance. Beyond the known influence of ApoE polymorphisms on serum lipid profile, the pathogenesis of atherosclerosis, and the development of neurodegenerative disorders, ApoE also has a major role in the pathogenesis and progression of a ...
Liberopoulos, E. +2 more
openaire +3 more sources
Apolipoprotein Mimetic Peptides: A New Approach for the Treatment of Asthma
Frontiers in Pharmacology, 2012 New treatments are needed for severe asthmatics to improve disease control and avoid severe toxicities associated with oral corticosteroids. We have used a murine model of house dust mite (HDM)-induced asthma to identify steroid-unresponsive genes that ...
Xianglan eYao +3 more
doaj +1 more source
Herpes Simplex Virus Type 1 in the Brain, Apolipoprotein E Genotype and Alzheimer’s Disease
McGill Journal of Medicine, 2020 The ε4 allele of apolipoprotein E (apoE) is an important risk factor for Alzheimer's disease (AD), however, it is not required nor sufficient to cause the disease on its own.
Uwe Beffert +4 more
doaj +1 more source
Clinical and Experimental Hypertension, 2021 Objective This study aimed to analyze the influence of SLCO1B1 and APOE gene polymorphisms on coronary heart disease in Mongolian population who living in Ordos area.
Rui-Bing Niu +6 more
doaj +1 more source
Association of APOE gene polymorphism with stroke patients from rural Eastern India
Annals of Indian Academy of Neurology, 2020 Context: Studies from the different ethnic regions of the world have reported variable results on association of APOE gene polymorphism in stroke. Aim: The aim of this study is to find out the possible association of APOE polymorphism in stroke patients ...
Hilal Ahmad Ganaie +5 more
doaj +1 more source
Sequence Analysis of APOE Gene Across Mammalian Species in Thailand
Science Technology and Engineering Journal (STEJ), 2021 The current study utilized five mammalian species, including rhesus monkey (Macaca mulatta), Thai Bangkaew dog (Canis lupus familiaris), Thai domestic cat (Felis catus), tiger (Panthera tigris) and Thai domestic rabbit (Oryctolagus cuniculus) to survey ...
Dechawut Bunyaluk +2 more
doaj +1 more source