Results 11 to 20 of about 20,685,408 (374)

Apolipoprotein E: from cardiovascular disease to neurodegenerative disorders. [PDF]

Journal of molecular medicine, 2016
Apolipoprotein (apo) E was initially described as a lipid transport protein and major ligand for low density lipoprotein (LDL) receptors with a role in cholesterol metabolism and cardiovascular disease.
Mahley, Robert W
core   +2 more sources

Apolipoprotein E and Alzheimer’s disease: The influence of apolipoprotein E on amyloid- and other amyloidogenic proteins [PDF]

Journal of Lipid Research, 2017
Alzheimer’s disease (AD) is one of the fastest-growing causes of death and disability in persons 65 years of age or older, affecting more than 5 million Americans alone.
Agosta, Alata, Albert A. Davis, Aleshkov, Allen, Alzheimer, Anderson, Atagi, Bailey, Bales, Bales, Bales, Basak, Bateman, Beffert, Beffert, Beffert, Bell, Bell, Benilova, Benjamin, Bernardi, Bertram, Bien-Ly, Bien-Ly, Biere, Brecht, Brunden, Bu, Caselli, Castellano, Castellano, Cedazo-Mínguez, Cheng, Cirrito, Cirrito, Cole, Cooper, Corder, Corder, Cotman, David M. Holtzman, de la Torre, Deane, Deane, DeMattos, Drory, Emamzadeh, Engelborghs, Esparza, Evans, Fabre, Fagan, Fagan, Farrer, Fryer, Fryer, Funato, Gallardo, Gallyas, Games, Gao, Garai, Govone, Greenberg, Grehan, Guerreiro, Gustafson, Halliday, Hardy, Harris, Harris, Heinonen, Hirsch-Reinshagen, Hirsch-Reinshagen, Holtzman, Holtzman, Holtzman, Holtzman, Hone, Hong, Hu, Huang, Huang, Huang, Hughes, Irizarry, Irwin, Irwin, Irwin, Iwai, Jakes, Jarrett, Jason D. Ulrich, Jellinger, Ji, Jiang, Jonsson, Josephs, Kanekiyo, Kehoe, Kim, Kim, Kim, Klunk, Klunk, Koistinaho, Koldamova, Korczyn, Kotzbauer, Lacomblez, LaDu, LaDu, Lashuel, Lee, Li, Li, Li, Li, Liao, Lill, Lippa, Liu, Liu, Ma, Mahley, Mahley, Mak, Mandrekar, Marchesi, Marder, Martin, Masliah, Mathis, Mattila, Mauch, McKee, Mikolaenko, Morris, Mui, Nalivaeva, Namba, Narita, Nathan, Nelson, Nielsen, Ohm, Panegyres, Paresce, Paresce, Pfeifer, Pfrieger, Pitas, Poirier, Praline, Rebeck, Rebeck, Reiman, Riemenschneider, Rockenstein, Roses, Roychaudhuri, Saavedra, Sabbagh, Saito, Sanan, Schmechel, Shaffer, Shibata, Siderowf, Srinivasan, Strittmatter, Strittmatter, Strittmatter, Sullivan, Sunderland, Szaruga, Tamamizu-Kato, Tesseur, Thal, Theendakara, Tien-Phat V. Huynh, Tiraboschi, Tokuda, Tsuang, Ulrich, Van Gool, van Horssen, Verghese, Wahrle, Wahrle, Wakabayashi, Wang, Watanabe, Wilson, Wisniewski, Wisniewski, Withers, Wood, Wyss-Coray, Yang, Ye, Yeh, Yuan, Zerbinatti, Zhang, Zhang, Zlokovic   +207 more
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Apolipoprotein E [PDF]

Definitions, 2020
openaire   +2 more sources

Apolipoprotein E in lipid metabolism and neurodegenerative disease.

Trends in endocrinology and metabolism, 2023
Dysregulation of lipid metabolism has emerged as a central component of many neurodegenerative diseases. Variants of the lipid transport protein, apolipoprotein E (APOE), modulate risk and resilience in several neurodegenerative diseases including late ...
Linda G. Yang, Z. March, R. Stephenson, P. Narayan   +3 more
semanticscholar   +1 more source

Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy

Molecular Psychiatry, 2022
Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer’s disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is characteristic of AD CSF, and predicts cognitive decline.
A. Belaidi, S. Masaldan, A. Southon, P. Kalinowski, Karla Acevedo, A. T. Appukuttan, S. Portbury, P. Lei, Puja Agarwal, S. Leurgans, J. Schneider, M. Conrad, A. Bush, Scott Ayton   +13 more
semanticscholar   +1 more source

Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB–Mediated Production of CXCL1

Cancer Research, 2021
This study shows that elevated apolipoprotein E in PDAC mediates immune suppression and high serum apolipoprotein E levels correlate with poor patient survival. Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with few effective therapeutic
Samantha B. Kemp, Eileen S. Carpenter, N. Steele, Katelyn L. Donahue, Z. Nwosu, Amanda Pacheco, Ashley Velez-Delgado, Rosa E. Menjivar, Fatima Lima, Stephanie The, Carlos E Espinoza, Kristee L Brown, Daniel Long, C. Lyssiotis, A. Rao, Yaqing Zhang, M. Pasca di Magliano, H. Crawford   +17 more
semanticscholar   +1 more source

Apolipoprotein E and Alzheimer's disease

Acta Pharmaceutica Sinica B, 2021
Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk. APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD.
B. Troutwine, Laylan Hamid, Colton R. Lysaker, Taylor A. Strope, Heather M. Wilkins   +4 more
semanticscholar   +1 more source

Apolipoprotein E is secreted by cultured lipocytes of the rat liver.

Journal of Lipid Research, 1991
Hepatic lipocytes, the retinoid-storing cells of the liver, share several characteristics with vascular smooth muscle cells. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA ...
G Friedman, LM Liu, SL Friedman, JK Boyles   +3 more
doaj   +1 more source

Association between clinical symptoms and apolipoprotein A1 or apolipoprotein B levels is regulated by apolipoprotein E variant rs429358 in patients with chronic schizophrenia

Annals of General Psychiatry, 2021
Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of ...
Wenwang Rao, Xiangfei Meng, Keqing Li, Yunshu Zhang, Xiang Yang Zhang   +4 more
doaj   +1 more source

Apolipoprotein E related Co-Morbidities and Alzheimer’s disease [PDF]

, 2016
The primary goal of advancement in clinical services is to provide a health care system that enhances an individual’s quality of life. Incidence of diabetes mellitus, cardiovascular disease and associated dementia coupled with the advancing age of the ...
Akiyama, Alharbi, Armitage, Armitage, Armitage, Balin, Barbieri, Bergdahl, Berliner, Borilova Linhartova, Borrell-Pages, Bowling, Braak, Braak, Brown, Bu, Buchanan, Burt, Cambell, Cavrini, Chiu, Chukkapalli, Chukkapalli, Chukkapalli, Cole, Corder, Corrada, Curtiss, Cutler, De Oliveira, DeFronzo, DeStefano, Desvarieux, Duarte, Epel, Farrer, Forner, Foster, Freitag-Wolf, Galbraith, Gan, Gao, Genco, Grehan, Grossi, Habib, Haffajee, Hajishengalis, Hajishengalis, Haraszthy, Hardardottir, Hardy, Harold, Harper, Hayashi, Hayden, Heiduschka, Helfand, Het, Hitt, Holt, Hu, Huang, Hunter, Hutton, Imhof, Iqbal, Itzhaki, Jagannathachary, Joiner, Kamer, Kamer, Kamer, Katz, Khovidhunkit, Klein, Kliegel, Kolovou, Kornman, Kozarov, Kubota, Lalla, Lambert, Lesne, Leszcynska, Libby, Machado, Mahley, Mahley, Mahley, Mahley, Maney, Marti, McGeer, Michalowicz, Miklossy, Miklossy, Miller, Mooradian, Moutsopoulos, Nagpal, Neto, Nicoll, Noble, Okuda, Olsen, Ono, O’Brien, Papapanou, Perls, Pitas, Pizzo, Poirier, Poling, Poole, Poole, Rivera, Riviere, Rogers, Rohn, Roses, Roses, Rowe, Saito, Saunders, Scannapieco, Schuett, Shao, Singhrao, Singhrao, Singhrao, Singhrao, Small, Smit, Socransky, Soscia, Stein, Strittmatter, Strittmatter, Sullivan, Velsko, Walsh, Walsh, Watkins, Weisgraber, Wetterau, Wilson, Young   +147 more
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