Results 211 to 220 of about 103,941 (262)
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Apolipoprotein in E in Myasthenia Gravis
Annals of the New York Academy of Sciences, 1998It is believed that apo E may moderate T lymphocytes by activation of mitogens or antigens. In that way, it has an influence on immune processes and it is reasonable to study the relationship between apo E genotypes and myasthenia gravis phenotypes. We tried to find any feature connected to the development of a different intensity of myasthenia gravis.
Šoštarko, Marija +5 more
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Genotyping of Apolipoprotein E
2003Apolipoprotein E (apo E) is a 299-amino acid plasma protein involved in cholesterol transport and is found in chylomicrons, very low density lipopro-tein, intermediate-density lipoprotein, and high-density lipoprotein (1,1).
I C, Ozturk, N, Akel, A A, Killeen
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Current Opinion in Neurology, 1996
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
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Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
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2013
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
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For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M. +2 more
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Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease
Ageing Research Reviews, 2009The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
SERIPA D +6 more
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Apolipoprotein E polymorphism and gallstones
Gastroenterology, 1996Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
A, Bertomeu +9 more
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Molecular biology of apolipoprotein E
Current Opinion in Lipidology, 2002Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein.
Warren J, Strittmatter, Carol, Bova Hill
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Apolipoprotein E genotype and psychosis
Biological Psychiatry, 1997Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD).
R, Igata-Yi +7 more
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ApolipoproteinE and Alzheimer's Disease
Biochemical Society Transactions, 1996Abstract: The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform‐ specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems.
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