Results 231 to 240 of about 20,685,408 (374)

Navigating the cholesterol maze: Key insights on use of statins in neurodegenerative disorders

Neuroprotection, EarlyView.
The graphical abstract encapsulates the dual neuroprotective mechanisms of statins in neurodegenerative diseases, highlighting both cholesterol‐dependent and cholesterol‐independent pathways. By inhibiting 3‐hydroxy‐3‐methylglutaryl coenzyme A (HMG‐CoA) reductase, statins reduce cholesterol synthesis, leading to altered lipid raft structures that ...
Jun Han Kuan, Roshan S. Raghavan, Dawn Li Wei Koh, Wing Yeng Tan, Igor Iezhitsa, Renu Agarwal   +5 more
wiley   +1 more source

Apolipoprotein E (APOE) regulates the transport of monosialotetrahexosylganglioside (GM1). [PDF]

J Biol Chem
Zhang DY, Wang J, Huang G, Dokholyan M, Willcox S, Griffith J, Ding F, Dokholyan NV.   +7 more
europepmc   +1 more source

Adipose Tissue‐Derived Small Extracellular Vesicles in Plasma Reveal Molecular Circuitries Underlying Glucose Intolerance

Obesity, EarlyView.
ABSTRACT Objective Glucose tolerance (GT) is a major effector for adipose tissue (AT) remodeling in obesity, yet its molecular mechanisms remain incompletely defined. We hypothesized that the biophysical and molecular profiles of AT‐derived small extracellular vesicles (sEVAT) change in response to glucose availability and differ by GT status.
Shalini Mishra, Yixin Su, Ashish Kumar, Sangeeta Singh, Brian S. Finlin, Fang‐Chi Hsu, Jingyun Lee, Cristina M. Furdui, Philip A. Kern, Swapan K. Das, Gagan Deep   +10 more
wiley   +1 more source

Editorial: Alzheimer’s disease [PDF]

Exploration of Neuroscience
Ryszard Pluta
doaj   +1 more source

Effect of saponins from gynostemma pentaphyllum on iron metabolism in apolipoprotein E deficient mice. [PDF]

Eur J Med Res
Huang T, Xiao X, Ma J, Fang J, Bao Y.
europepmc   +1 more source

Alzheimer's disease related senile plaque accumulation and apolipoprotein-E genotype in a non-demented population

, 2016
Tiia Miettinen
openalex   +1 more source

Cyclic AMP Induces Apolipoprotein E Binding Activity and Promotes Cholesterol Efflux from a Macrophage Cell Line to Apolipoprotein Acceptors

, 1996
Jonathan D. Smith, Masaaki Miyata, Michael D. Ginsberg, Claire Grigaux, Eric Shmookler, Andrew Plump   +5 more
openalex   +1 more source

Protein deglycosylation can drastically affect the cellular uptake [PDF]

, 2019
Ghazaryan, A., Landfester, K., Mailänder, V.   +2 more
core   +2 more sources

Single‐Cell Nanodroplet Processing Proteomics Pipeline for Analysis of Human‐Derived Microglia

PROTEOMICS, EarlyView.
ABSTRACT Single‐cell omics tools provide unique insights into heterogeneous cell populations and their responses to stimuli. For example, single‐cell RNA sequencing has identified several transcriptionally distinct populations of microglia, which are resident immune cells of the central nervous system (CNS) that are responsive to CNS injury, infection,
Ashley N. Ives, James M. Fulcher, Alex R. Bautista, Reta Birhanu Kitata, Sarah M. Williams, David A. Bennett, Philip L. De Jager, Vladislav A. Petyuk   +7 more
wiley   +1 more source

Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia. [PDF]

Int J Mol Sci
Liampas I, Demiri S, Siokas V, Tsika A, Marogianni C, Stamati P, Nasios G, Messinis L, Lyketsos CG, Dardiotis E.   +9 more
europepmc   +1 more source