Results 251 to 260 of about 207,429 (294)

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, EarlyView.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source

Apolipoprotein E drives microglia activation in the development of autoimmune uveitis through up-regulation of peptidyl prolyl isomerase F. [PDF]

Sci Adv
Zeng S, Wang Y, Liu X, Feng H, Cao F, Chu B, Wu C, Fan W, Hu K, Lei F, Hou S.   +10 more
europepmc   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, EarlyView.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

Apolipoprotein E-Containing High-Density Lipoprotein is Independently Associated with Atherosclerotic Plaque Progression. [PDF]

J Atheroscler Thromb
Ni P, Li J, Duan Y, Hu P, Deng Q, Hao Y, Yang Z, Han L, Qi Y, Liu J.   +9 more
europepmc   +1 more source

Cardiovascular Health in Women—Across the Lifespan

Clinical Endocrinology, EarlyView.
ABSTRACT Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity among women worldwide. However, CVD continues to be perceived as a predominantly male issue. CVD in women therefore remains understudied, underrecognized and undertreated.
Jaya Chandrasekhar, Jessica Yao, Simone Gong, Madhuka Wijayarathne, Monique Watts, Swati Mukherjee   +5 more
wiley   +1 more source

Correction: Pre-treatment serum apolipoprotein E: a promising prognostic indicator for nasopharyngeal carcinoma. [PDF]

Eur J Med Res
He XM, Jiang SC, Luo QW, Ding JW, Hu RH, Hu JL, Liu MM, Tao L, Zhang JZ, Wu JY, Deng S, Zeng L.   +11 more
europepmc   +1 more source

Dynamics of Apolipoprotein J Levels and Metabolic Parameters Following Bariatric Surgery

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Bariatric surgery has emerged as a potent intervention for ameliorating insulin resistance and its associated comorbidities in obese patients. Apolipoprotein J (ApoJ) and adiponectin are closely associated with insulin resistance and sensitivity, respectively.
Kellen Cristina da Cruz Rodrigues, Minjin Lee, Yejee Lim, Jennie Young, Brendon Chung, Susan Phillips, Theodore P. Ciaraldi, Young‐Bum Kim   +7 more
wiley   +1 more source

Relationship Between Apolipoprotein E Genotypes, Unhealthy Weight Status, and Cognitive Impairment in Older Adults of Predominantly African Descent. [PDF]

Diseases
Clotilde JP, Nicolas L, Larifla L, Velayoudom FL, Gaete S, Ancedy Y, Cirederf I, Fanhan R, Foucan L.   +8 more
europepmc   +1 more source

The Need to Promote Olfactory Health in Public Health Agendas Across the Globe

Clinical Otolaryngology, EarlyView.
ABSTRACT Background A good sense of smell is essential for physical and mental health, and social wellbeing; however, across the globe, regardless of the setting, national public health agendas never consider smell health. This review aims to summarise the wide‐reaching impact of smell health in public health. Methods Narrative review of the literature
Carl Martin Philpott, Thomas Hummel, Valentina Parma, Matt Lechner, Duncan Boak, Marianna Obrist   +5 more
wiley   +1 more source