Results 261 to 270 of about 195,708 (344)

No effect of apolipoprotein E polymorphism on MRI brain activity during movie watching. [PDF]

Brain Neurosci Adv
Raykov PP, Daly J, Fisher SE, Eising E, Geerligs L, Bird CM.   +5 more
europepmc   +1 more source

Population Studies of Polymorphisms at Loci of Neuropsychiatric Interest (Tryptophan Hydroxylase (TPH), Dopamine Transporter Protein (SLC6A3), D3 Dopamine Receptor (DRD3), Apolipoprotein E (APOE), μ Opioid Receptor (OPRM1), and Ciliary Neurotrophic Factor (CNTF))

, 1998
Joel Gelernter, Henry R. Kranzler, James Lacobelle   +2 more
openalex   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

Prognostic Value of Apolipoprotein E in Predicting One-year Mortality in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. [PDF]

Int J Chron Obstruct Pulmon Dis
Li Y, Wu Q, Li Z, Xiao Y, Wei L.
europepmc   +1 more source

Apolipoprotein E phenotypes in patients with gout: relation with hypertriglyceridaemia.

, 1995
Yasuhiro Moriwaki, Tetsuya Yamamoto, Satoru Takahashi, Z. Tsutsumi, Kazuya Higashino   +4 more
openalex   +1 more source

Population Pharmacokinetics and Exposure‐Response Modeling for Evinacumab in Children, Adolescents, and Adults With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 (ANGPTL3) inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C), independent of low‐density lipoprotein receptor, in patients with homozygous familial hypercholesterolemia (HoFH). A population pharmacokinetic (PK)/pharmacodynamic (PD) model was previously developed to characterize ...
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Yuhuan Wang, Poulabi Banerjee, Robert Pordy, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +8 more
wiley   +1 more source

Comparison of Model‐Predicted and Observed Evinacumab Pharmacokinetics and Efficacy in Children Aged < 5 Years With Homozygous Familial Hypercholesterolemia

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Evinacumab, an angiopoietin‐like 3 inhibitor, significantly reduces low‐density lipoprotein cholesterol (LDL‐C) in patients with homozygous familial hypercholesterolemia (HoFH). Herein, we report pharmacokinetic and efficacy analyses of evinacumab in < 5‐year‐old patients with HoFH.
Sébastien Bihorel, Robert Dingman, Jeanne Mendell, Katy C. Norman, Richard T. George, Xue‐Qiao Zhao, Robert Pordy, Daniel Garcia, Wendy S. Putnam, Geetha Raghuveer, Brian W. McCrindle, Elena Fornari, Ivo Baric, Shubha Srinivasan, Melissa Diamond, Eliot A. Brinton, John D. Davis, A. Thomas DiCioccio, Lutz Harnisch   +18 more
wiley   +1 more source

Correction: Exercise reduces hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice via its effects against inflammation and oxidative stress. [PDF]

Sci Rep
Pei Z, Ji J, Gao Y, Wang H, Wu Y, Yang J, Yang Q, Zhang L.   +7 more
europepmc   +1 more source

Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell, Amin Rostami‐Hodjegan, Guy Meno‐Tetang, Donald E. Mager, Kayode Ogungbenro   +4 more
wiley   +1 more source

Recruitment of apolipoprotein E facilitates Herpes simplex virus 1 attachment and release. [PDF]

Npj Viruses
Liu L, Bano F, Conca DV, Thorsteinsson K, Jayaweera SW, Avinens D, Pace H, Lövheim H, Olofsson A, Bally M.   +9 more
europepmc   +1 more source