Results 61 to 70 of about 334,081 (324)
, 2022 Cancer Communications, Volume 42, Issue 12, Page 1407-1411, December 2022.
Chao Liu +9 more
wiley +1 more source
Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023 Dyslipidemias, hepatic steatosis index, and ABCA1 (rs1800977) gene polymorphism CC genotype; were the only independent predictors of advanced fibrosis in NAFLD‐patients. Abstract Introduction It had been evident that non‐alcoholic fatty liver disease (NAFLD) is the new era epidemic.
Samar E. Ghanem +7 more
wiley +1 more source
Lipoprotein Glomerulopathy, First Case Report from Canada
International Journal of Nephrology and Renovascular Disease, 2022 Julie Anne Ting,1 Susanna A McRae,1,2 Daniel Schwartz,1 Sean J Barbour,1 Maziar Riazy1,2 1Division of Nephrology, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada; 2Department of Pathology, University of British Columbia, Vancouver, BC, V6Z
Ting JA +4 more
doaj
Folding of the apolipoprotein A1 driven by the salt concentration as a possible mechanism to improve cholesterol trapping [PDF]
arXiv, 2014 The folding of the cholesterol trapping apolipoprotein A1 in aqueous solution at increasing ionic strength is studied using atomically detailed molecular dynamics simulations. We calculate various structural properties to characterize the conformation of the protein, such as the radius of gyration, the radial distribution function and the end to end ...
arxiv
Role of Apolipoprotein E in Anxiety
Neural Plasticity, 2007 Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in ...
openaire +3 more sources
Advanced Functional Materials, EarlyView.Supramolecular biomimetic nanoaggregates (HFCu NAs), constructed with fluorinated histidine and copper ions via metal coordination and aromatic packing, exhibit enhanced reactive oxygen species （ROS）generation at tumor sites, which results in stepwise collapse of the extracellular matrix (ECM), affording tumor microenvironment responsive “turn‐on” 19F ...
Hui Wang +8 more
wiley +1 more source
Antigen targeting to dendritic cells: Still a place in future immunotherapy?
European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022 Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner +4 more
wiley +1 more source
Observation of Cholesterol Dissolved in Microscopic Deposits of Free Fatty Acids in the Lumen of an Aorta of a Mouse Model for Human Atherosclerosis [PDF]
SPIE 7 5321A-11 (2004), 2008 The Raman spectrum of microscopic droplets of lipid material on the lumen of the aorta of an apolipoprotein E knock-out mouse were reported in the proceedings of an SPIE conference. Based on the absence of the carbonyl band in the spectrum, at that time it was determined that the spectrum represents free fatty acids rather than triglycerides.
arxiv
Hydroxyapatite Binding Peptide Lipid Nanoparticles for Biomimetic mRNA Delivery to Bone
Advanced Therapeutics, EarlyView.Targeted delivery of therapeutic mRNA to peripheral tissues, including bone, is currently challenging. In the current work, a hydroxyapatite binding peptide (HABP) is conjugated to mRNA lipid nanoparticles (LNPs). HABP‐LNPs delivered systemically are demonstrated to reduce transfection in the liver and improve transfection in the femurs of mice ...
Joshua A. Choe +6 more
wiley +1 more source
ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022 Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen +3 more
wiley +1 more source