Results 61 to 70 of about 20,685,408 (374)

Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation

Nature Communications, 2018
Cholesterol homeostasis has a pivotal function in regulating immune cells. Here we show that apolipoprotein E (apoE) deficiency leads to the accumulation of cholesterol in the cell membrane of dendritic cells (DC), resulting in enhanced MHC-II-dependent ...
F. Bonacina, D. Coe, Guosu Wang, M. Longhi, A. Baragetti, A. Moregola, K. Garlaschelli, P. Uboldi, F. Pellegatta, L. Grigore, L. Da Dalt, A. Annoni, S. Gregori, Q. Xiao, D. Caruso, N. Mitro, A. Catapano, F. Marelli-Berg, G. Norata   +18 more
semanticscholar   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

IMPORTANCE OF PLASMA E APOLYPROTEIN DOSAGE, OF GENETIC POLYMORPHISM AND LIPID PROFILE IN DIABETIC PATIENTS [PDF]

Romanian Journal of Medical Practice, 2019
Apolipoproteine E (ApoE) is known for its ability to suppress atherosclerosis. Besides its activity to remove the remaining lipoproteins from plasma, ApoE is also known for its direct influence on the numerous cells of the vascular walls, immune system ...
Silviu Daniel Moldovan, Romana Olivia Popețiu, Oana Lucia Amza, Luminiţa Pilat, Maria Pușchiță   +4 more
doaj   +1 more source

Effects of dalcetrapib in patients with a recent acute coronary syndrome [PDF]

, 2012
In observational analyses, higher levels of high-density lipoprotein (HDL) cholesterol have been associated with a lower risk of coronary heart disease events.
Abt, Markus, Ballantyne, Christie M., Barter, Philip J., Brumm, Jochen, Chaitman, Bernard R., Colquhoun, David, Holme, Ingar M., Kallend, David, Leiter, Lawrence A., Leitersdorf, Eran, McMurray, John J. V., Mundl, Hardi, Nicholls, Stephen J., Olsson, Anders G., Schwartz, Gregory G., Shah, Prediman K., Tardif, Jean-Claude, The dal-OUTCOMES Investigators, Wright, R. Scott   +18 more
core   +2 more sources

CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang, Yujie Liu, Fei Li, Xuelin Li, Lanlan Li, Jie Zhang, Yali Xu   +6 more
wiley   +1 more source

High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer’s disease [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Alzheimer’s disease (AD) is a major public concern and one of the primary types of dementia characterized by memory impairment and cognitive decline.
Mohamad Reza Kordi, Nooshin Khademi, Amir Mohammad Zobeydi, Samane Torabi, Esmaeil Mahmoodifar, Abbasali Gaeini, Siroos choobineh, Parisa Pournemati   +7 more
doaj   +1 more source

Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]

, 2016
The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T, Bateman, Randall J, Bollinger, James G, Cairns, Nigel J, Franklin, Erin E, Holtzman, David, Jiang, Hong, Kasten, Tom, Liao, Fan, Mawuenyega, Kwasi G, Morris, John C, Ovod, Vitaliy   +11 more
core   +3 more sources

PRELIVE: A Framework for Predicting Lipid Nanoparticles In Vivo Efficacy and Reducing Reliance on Animal Testing

Advanced Functional Materials, EarlyView.
PREdicting LNP In Vivo Efficacy (PRELIVE) framework enables the prediction of lipid nanoparticle (LNPs) organ‐specific delivery through dual modeling approaches. Composition‐based models using formulation parameters and protein corona‐based models using biological fingerprints both achieve high predictive accuracy across multiple organs.
Belal I. Hanafy, Chuan‐En Lu, Kai Liu, Audrey Gallud   +3 more
wiley   +1 more source

Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis

Hypertension in Pregnancy, 2020
Objective The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE. Methods A comprehensive search was carried out through PubMed, Scopus, and Embase.
Morteza Abyadeh, Fatemeh Heydarinejad, Maliheh Khakpash, Yaser Asefi, Sakineh Shab-Bidar   +4 more
doaj   +1 more source

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Alber, KF, Bassett, P, Chambers, S, Croca, S, Davari, M, Giles, I, Ioannou, Y, Isenberg, D, Leach, O, Rahman, A   +9 more
core   +1 more source