Results 61 to 70 of about 194,689 (341)

Apolipoprotein E Uptake and Low-Density Lipoprotein Receptor-Related Protein Expression by the NTera2/D1 Cell Line: A Cell Culture Model of Relevance for Late-Onset Alzheimer's Disease

Neurobiology of Disease, 1997
Apolipoprotein E has been shown to be a risk factor for late-onset Alzheimer's disease, with the apolipoprotein ϵ4 allele conferring the risk. Apolipoprotein E is found in neurofibrillary tangles and senile plaques, the pathological characteristics of ...
Kieran R. Williams, Victoria Pye, Ann M. Saunders, Allen D. Roses, Patricia J. Armati   +4 more
doaj  

APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES [PDF]

Romanian Medical Journal, 2019
Apolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides-rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins (HDL).
Silviu Daniel Moldovan, Romana Olivia Popeţiu, Oana Lucia Amza, Maria Puşchiţă   +3 more
doaj   +1 more source

Production of a soluble and functional recombinant apolipoproteinD in the Pichia pastoris expression system [PDF]

, 2016
ApolipoproteinD (ApoD) is a human glycoprotein from the lipocalin family. ApoD contains a conserved central motif of an 8-stranded antiparallel β-sheet, which forms a beta-barrel that can be used for transport and storage of diverse hydrophobic ligands ...
Armanmehr, S., Kalhor, H.R., Tabarraei, A.   +2 more
core   +1 more source

Advanced Multipurpose Spectroscopic Nanobio‐Device for Concurrent Lab‐on‐a‐Chip Label‐Free Separation and Detection of Extracellular Vesicles as Key‐Biomarkers for Point‐of‐Care Cardiovascular Disease Diagnostics

Advanced Healthcare Materials, EarlyView.
AIMSPec‐LoC is a novel lab‐on‐a‐chip platform integrating size‐based extracellular vesicle (EVs) separation with label‐free Raman spectroscopy and AI‐powered classification via SKiNET. This high‐throughput, portable system enables real‐time, multiplexed molecular fingerprinting of EVs from biofluids, offering transformative potential for early, non ...
Emma Buchan, Jonathan James Stanley Rickard, Mark Robert Thomas, Pola Goldberg Oppenheimer   +3 more
wiley   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Role of Apolipoprotein E in Anxiety

Neural Plasticity, 2007
Anxiety is most common among Alzheimer's disease (AD) patients with an age at onset under age 65. Apolipoprotein E4 (apoE4) is a risk factor for developing AD at an earlier age and might contribute to this effect. In mice, apoE plays a role in the regulation of anxiety, which might involve histamine receptor-mediated signaling and steroidogenesis in ...
openaire   +3 more sources

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer’s disease [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Alzheimer’s disease (AD) is a major public concern and one of the primary types of dementia characterized by memory impairment and cognitive decline.
Mohamad Reza Kordi, Nooshin Khademi, Amir Mohammad Zobeydi, Samane Torabi, Esmaeil Mahmoodifar, Abbasali Gaeini, Siroos choobineh, Parisa Pournemati   +7 more
doaj   +1 more source

Utilization of cognitive support in episodic free recall as a function of apolipoprotein E and vitamin B12 or folate among adults aged 75 years and older [PDF]

, 2004
Apolipoprotein E (APOE), vitamin B12, and folate were examined in relation to free recall among 167 community-based older adults. Cognitive support at encoding and retrieval was also taken into account.
Bunce, D, Kivipelto, M, Wahlin, A
core