Results 71 to 80 of about 103,941 (262)
International Journal of Nanomedicine, 2021 Jia Ouyang,1 Yu Jiang,2 Chao Deng,2 Zhiyuan Zhong,2 Qing Lan1 1Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People’s Republic of China; 2Biomedical Polymers Laboratory, College of Chemistry ...
Ouyang J +4 more
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Кардиоваскулярная терапия и профилактика, 2020 Aim. To analyze the associations of apolipoprotein E (APOE) gene polymorphisms (rs7412 and rs4420638) with the risk of coronary artery disease (CAD) and the effectiveness of lipid-lowering therapy with rosuvastatin.Material and methods.
M. I. Churilin +12 more
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Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
Исследования и практика в медицине, 2015 Objective. APOE genotype association with the level of iron in plasma and the risk of endometrial neoplastic diseases has not been studied. The aim of the work was to analyze the genotypic associations of the apolipoprotein E (APOE) with iron and lipid ...
T. A. Ivanova +8 more
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Advanced Science, EarlyView.Sterol engineering enables precise control of mRNA lipid nanoparticles by tuning membrane organization. Replacing cholesterol with bile acid‐derived sterols redirects protein expression from the liver to the spleen. Notably, CA‐20 LNP enhances antigen‐specific immune responses while exhibiting a favorable safety profile, highlighting sterols as a ...
Sanghyuk Jeon +27 more
wiley +1 more source
Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions
Journal of Integrative NeuroscienceAlzheimer’s disease (AD) is a multifactorial neurodegenerative disease that is conventionally characterized by amyloid-β and tau pathology. There is growing evidence, however, that lipid metabolic disturbances are part of the biology of the disease, and ...
Jeyakumar Balakrishnan +3 more
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International Journal of General Medicine, 2023 Caiyan Gan,1– 3 Yinmei Zhang,1– 3 Xianyan Zhang,4 Qionghui Huang,1– 3 Xuemin Guo1– 4 1Research Experimental Center, Meizhou People’s Hospital, Meizhou, People’s Republic of China; 2Guangdong Engineering Technological Research Center of Clinical Molecular
Gan C, Zhang Y, Zhang X, Huang Q, Guo X
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Lipids in Health and Disease, 2019 Background Chronic kidney disease (CKD) associates with complex lipoprotein disturbances resulting in high cardiovascular risk. Apolipoprotein E (APOE) is a polymorphic protein with three common isoforms (E2; E3; E4) that plays a crucial role in ...
Monika Czaplińska +9 more
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Advanced Science, EarlyView.CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou +14 more
wiley +1 more source
Zhongguo cuzhong zazhi目的 分析不同载脂蛋白E（apolipoprotein E，APOE）基因型急性缺血性卒中患者的临床特征差异，探讨APOE基因多态性与卒中后认知功能变化的相关性。 方法 本研究基于多中心、前瞻性的中国血管性认知障碍预测、预防和个性化研究，纳入2022年9月1日—2023年8月31日中国6家医疗机构收治的急性缺血性卒中患者，收集入组患者基线期年龄、性别、受教育年限、BMI、既往史（高血压、糖尿病、心脏病、高脂血症、卒中或TIA）、吸烟史、饮酒史、药物治疗史、NIHSS评分、MoCA评分 ...
李汶逸，姜季委，任琦玮，王琳琳，赵敏，徐俊LI Wenyi, JIANG Jiwei, REN Qiwei, WANG Linlin, ZHAO Min, XU Jun
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