Results 81 to 90 of about 103,941 (262)

Effect of Apolipoprotein E ϵ4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels

Pharmacogenomics and Personalized Medicine, 2022
Wenbing Ma,1,2,* Liting Zhang,1,* Lei Luo,1 Suya Zhang,1,* Shuang Yang,1 Hongping Yao,1 Lei Zhang,1 Xiaoyun Lu,2 Weiyi Feng1 1Department of Pharmacology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061 ...
Ma W, Zhang L, Luo L, Zhang S, Yang S, Yao H, Zhang L, Lu X, Feng W   +8 more
doaj  

Membranous Nephropathy-Like Apolipoprotein E Deposition Disease with Apolipoprotein E Toyonaka (Ser197Cys) and a Homozygous Apolipoprotein E2/2

Case Reports in Nephrology and Dialysis, 2018
A 20-year-old female student underwent renal biopsy because of chance proteinuria and hematuria. Histological study revealed a membranous nephropathy-like appearance by light microscopy. But immunoglobulins and complements were negative in the glomerulus
Megumu Fukunaga, Kiyotaka Nagahama, Michiko Aoki, Akira Shimizu, Shigeo Hara, Akira Matsunaga, Eri Muso, Takao Saito   +7 more
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, EarlyView.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

Association between mild cognitive impairment and APOE Ɛ4, low education level, and lack of spousal relationship in community-dwelling older persons in Nigeria

Current Medicine Research and Practice
Background: Apolipoprotein Ɛ4 has been established as a risk factor for cognitive impairment and dementia among Caucasians; however, the relationship among Black Africans has not been consistent.
Isyaku Gwarzo Mukhtar, Mohamed Mabrouk Elkhashab, Muhammad Ali Salim, Salisu Ahmed Ibrahim, Isyaku Umar Yarube   +4 more
doaj   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

Association of the serum level of apolipoprotein E with coronary artery disease and carotid artery atherosclerosis in Kyrgyz men with dyslipidemia

Терапевтический архив, 2010
Aim: to study an association of the serum level of apolipoprotein E (apo-E) with risk factors for coronary heart disease (CHD), blood lipids and that with CHD and carotid artery (CA) atherosclerotic lesion in Kyrgyz men with dyslipidemia.
Ol'ga Sergeevna Lunegova, Magdalena Andreevna Pavlenko, Alina Suyyunbekovna Kerimkulova, Aygul' Mukashevna Noruzbaeva, Bermet Tazabekovna Samanchina, Yuliana Vladimirovna Zalesskaya, Saamay Sagymbaevna Abilova, Aybek Erkiovich Mirrakhimov, Cholpon Bolotbekovna Moldokeeva, E M Mirrakhimov, O S Lunegova, M A Pavlenko, A S Kerimkulova, A M Noruzbayeva, B T Samanchina, Yu V Zalesskaya, S S Abilova, A E Mirrakhimov, Ch B Moldokeyeva, E M Mirrakhimov   +19 more
doaj  

High-intensity interval training combined with cannabidiol supplementation improves cognitive impairment by regulating the expression of apolipoprotein E, presenilin-1, and glutamate proteins in a rat model of amyloid β-induced Alzheimer’s disease [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Alzheimer’s disease (AD) is a major public concern and one of the primary types of dementia characterized by memory impairment and cognitive decline.
Mohamad Reza Kordi, Nooshin Khademi, Amir Mohammad Zobeydi, Samane Torabi, Esmaeil Mahmoodifar, Abbasali Gaeini, Siroos choobineh, Parisa Pournemati   +7 more
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

Association of Apolipoprotein E gene polymorphism with Preeclampsia: a meta-analysis

Hypertension in Pregnancy, 2020
Objective The aim of this meta-analysis was to examine the association of ApoE polymorphism with the risk of developing PE. Methods A comprehensive search was carried out through PubMed, Scopus, and Embase.
Morteza Abyadeh, Fatemeh Heydarinejad, Maliheh Khakpash, Yaser Asefi, Sakineh Shab-Bidar   +4 more
doaj   +1 more source