Results 81 to 90 of about 121,670 (308)

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Association of the serum level of apolipoprotein E with coronary artery disease and carotid artery atherosclerosis in Kyrgyz men with dyslipidemia

Терапевтический архив, 2010
Aim: to study an association of the serum level of apolipoprotein E (apo-E) with risk factors for coronary heart disease (CHD), blood lipids and that with CHD and carotid artery (CA) atherosclerotic lesion in Kyrgyz men with dyslipidemia.
Ol'ga Sergeevna Lunegova, Magdalena Andreevna Pavlenko, Alina Suyyunbekovna Kerimkulova, Aygul' Mukashevna Noruzbaeva, Bermet Tazabekovna Samanchina, Yuliana Vladimirovna Zalesskaya, Saamay Sagymbaevna Abilova, Aybek Erkiovich Mirrakhimov, Cholpon Bolotbekovna Moldokeeva, E M Mirrakhimov, O S Lunegova, M A Pavlenko, A S Kerimkulova, A M Noruzbayeva, B T Samanchina, Yu V Zalesskaya, S S Abilova, A E Mirrakhimov, Ch B Moldokeyeva, E M Mirrakhimov   +19 more
doaj  

Role of apolipoprotein E in neurodegenerative diseases

, 2015
Vo Van Giau,1 Eva Bagyinszky,1 Seong Soo A An,1 SangYun Kim2 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Seongnam, South Korea; 2Department of Neurology, Seoul National University College of Medicine in Seoul
Kim SY, An SS, Giau VV, Bagyinszky E
core  

Effect of Apolipoprotein E epsilon 4 on the association between health behaviors and cognitive function in late midlife

, 2010
The extent to which the effect of risk factors on cognitive ageing is dependent on APOE epsilon 4 remains unclear. The objective of this study is to examine whether APOE epsilon 4 allele modifies the association between health behaviors and cognition in ...
Kumari, Meena, Singh-Manoux, Archana, Kivimaki Mika, Séverine Sabia, Sabia, Séverine, Mika Kivimaki, Kivimaki, Mika, Sabia Séverine, Kivimaki, M, Singh-Manoux Archana, Archana Singh-Manoux, Kumari Meena, Martin J Shipley, Meena Kumari, Singh-Manoux, A, Shipley, MJ, Shipley Martin J, Sabia, S, Kumari, M, Shipley, Martin   +19 more
core   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Research progress on the mechanisms of apolipoprotein E in Alzheimer’s disease

Guoji laonian yixue zazhi
Alzheimer’s disease (AD) is a degenerative disorder of the central nervous system that predominantly affects the elderly.The Apolipoprotein E (ApoE) gene is identified as the most significant genetic factor associated with AD.This article reviews current
Jiayuan Li, Ting Liu, Shengxi Meng
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Diagnostic Accuracy of Serum Calcitonin Gene-Related Peptide and Apolipoprotein E in Migraine: A Preliminary Study

International Journal of General Medicine, 2021
Rabia Latif,1 Nazish Rafique,1 Lubna Al Asoom,1 Ahmed A Alsunni,1 Ayad Mohammed Salem,1 Dinah Abdulhadi AlNoaimi,2 Wasan Mohammed AlHarbi,2 Ahad Yasir Shaikh,2 Shoug Abdullah AlRaddadi,2 Leena Abdulrahman AlMuhaish,2 Dana Almohazey,3 Sayed Abdulazeez,4 J
Latif R, Rafique N, Al Asoom L, Alsunni AA, Salem AM, AlNoaimi DA, AlHarbi WM, Shaikh AY, AlRaddadi SA, AlMuhaish LA, Almohazey D, Abdulazeez S, Borgio JF   +12 more
doaj  

Heredity Links Natural Hazards and Human Health: Apolipoprotein E Gene Moderates the Health of Earthquake Survivors [PDF]

, 2011
Objective: This study aimed to investigate the role of the apolipoprotein ε4 allele in moderating the influence of an exogenous stressor, an earthquake, on health.
Daly, Michael, Malcolm MacLachlan, Michael Daly, MacLachlan, Malcolm   +3 more
core   +1 more source