Results 101 to 110 of about 121,670 (308)

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Multiple system atrophy and apolipoprotein E

, 2018
Background: Dysregulation of the specialized lipid metabolism involved in myelin synthesis and maintenance by oligodendrocytes has been associated with the unique neuropathology of MSA.
Alexandra I. Soto, Henrietta M. Nielsen, Zbigniew K. Wszolek, Dickson, Dennis W., Owen A. Ross, Anna I. Wernick, Jay A. van Gerpen, Low, Phillip A., Yuka A. Martens, Walton, Ronald L., Ross, Owen A., Singer, Wolfgang, Wolfgang Singer, Koga, Shunsuke, Kanekiyo, Takahisa, Vargas, Emily R., Bu, Guojun, Wszolek, Zbigniew K., Martens, Yuka A., Lorenzo-Betancor, Oswaldo, Soto, Alexandra I., Labbe, Catherine, van Gerpen, Jay A., Ronald L. Walton, Ryan J. Uitti, Heckman, Michael G., Nielsen, Henrietta M., Shunsuke Koga, Oswaldo Lorenzo‐Betancor, William P. Cheshire, Wernick, Anna I., Uitti, Ryan J., Guojun Bu, Takahisa Kanekiyo, Fujioka, Shinsuke, Shinsuke Fujioka, Dennis W. Dickson, Phillip A. Low, Ogaki, Kotaro, Cheshire, William P., Catherine Labbé, Emily R. Vargas, Nielsen, Henrietta M.,, Kotaro Ogaki, Michael G. Heckman   +44 more
core   +1 more source

Dual Functions of Dietary Rubber Seed Oil Supplementation: Enriching N‐3 Polyunsaturated Fatty Acids and Enhancing Antioxidant Capacity in Pekin Ducks

Animal Research and One Health, EarlyView.
Dietary RSO supplementation improved growth performance, simultaneously enriched n‐3 polyunsaturated fatty acids (n‐3 PUFA), and enhanced antioxidant capacity in Pekin ducks, which suggested that RSO has the potential to be a novel n‐3 PUFA source and an antioxidant for Pekin ducks to generate animal functional foods.
Lei Zhuang, Yongbao Wu, Zitao Zhao, Junting Cao, Yanhong Guo, Zhanyue Wu, Qimeng Wang, Peilong Yang, Sen Wu, Zhiguo Wen, Shuisheng Hou   +10 more
wiley   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, EarlyView.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

Doxorubicin Delivered via ApoE-Directed Reduction-Sensitive Polymersomes Potently Inhibit Orthotopic Human Glioblastoma Xenografts in Nude Mice

International Journal of Nanomedicine, 2021
Jia Ouyang,1 Yu Jiang,2 Chao Deng,2 Zhiyuan Zhong,2 Qing Lan1 1Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, People’s Republic of China; 2Biomedical Polymers Laboratory, College of Chemistry ...
Ouyang J, Jiang Y, Deng C, Zhong Z, Lan Q   +4 more
doaj  

ApoE gene therapy: an overview and update

, 2005
Atherosclerosis remains the leading cause of death in industrialized societies. Apolipoprotein E (ApoE) is an attractive candidate to treat hypercholesterolemia and coronary heart disease, as it is a circulating protein with pleiotropic ...
Owen, J.S.
core  

Elevated apolipoprotein(A) levels in cancer patients

, 1989
Elevated plasma lipoprotein(a) has been associated with an increased risk of cardiovascular disease. We report a significant elevation of total plasma apolipoprotein(a) levels in cancer patients compared with hospitalized control patients and normal ...
Dyne, Marlen, Mountford, Carolyn E., Wright, Lesley C., Tattersall, Martin H. N., Sullivan, David R., Muller, Mark   +5 more
core   +1 more source

Application of apolipoprotein E-modified liposomal nanoparticles as a carrier for delivering DNA and nucleic acid in the brain [PDF]

, 2014
Mina Tamaru,* Hidetaka Akita,* Taichi Nakatani, Kazuaki Kajimoto, Yusuke Sato, Hiroto Hatakeyama, Hideyoshi Harashima Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan *These authors contributed equally to this work Abstract: An
Nakatani T, Sato, Yusuke, Akita, Hidetaka, Nakatani, Taichi, Hatakeyama, Hiroto, Tamaru, Mina, Sato Y, Hatakeyama H, Kajimoto K, Harashima, Hideyoshi, Harashima H, Tamaru M, Kajimoto, Kazuaki, Akita H   +13 more
core   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

Secretion of lipoproteins, apolipoprotein A-I and apolipoprotein E by isolated and perfused liver of rat with experimental nephrotic syndrome.

, 1981
Nephrotic syndrome induced in the rat by the administration of puromycin aminonucleoside is accompanied by a hyperlipoproteinemia characterized by an elevation of all plasma lipoproteins, particularly of VLDL (1.006 g/ml) and HDL1 (1.050-1.090 g/ml). The
Bartosek I., Fainaru M, CALANDRA BUONAURA, Sebastiano, Gherardi E, Guaitani A   +4 more
core