Results 71 to 80 of about 194,689 (341)
Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism [PDF]
, 2018 Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3.
Herz, Joachim +9 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.Engineering of a functional protein corona with a synergistic heparin‐ATIII complex significantly improves hemocompatibility of PEG nanoparticles. Through deliberate engineering of the protein corona, a 4‐fold reduction in coagulation activation (F1 + 2) without inducing adverse thromboinflammatory reactions (CD11b, C5a) is achieved without disrupting ...
Vaidehi Londhe +5 more
wiley +1 more source
Apolipoprotein E ε4 is superior to apolipoprotein E ε2 in predicting cognitive scores over 30 months
Clinical Interventions in Aging, 2013 Paul Regal, Balakrishnan Nair, Eileen Hetherington Geriatric Medicine and Gerontology, University of Newcastle, Callaghan, NSW, Australia Background: The purpose of this study was to compare apolipoprotein E ε4 (Apo E ε4) and ...
Regal P, Nair B, Hetherington E
doaj
Case Reports in Nephrology and Dialysis, 2018 A 20-year-old female student underwent renal biopsy because of chance proteinuria and hematuria. Histological study revealed a membranous nephropathy-like appearance by light microscopy. But immunoglobulins and complements were negative in the glomerulus
Megumu Fukunaga +7 more
doaj +1 more source
Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin [PDF]
, 2010 OBJECTIVE The aim of this study was to investigate whether apolipoprotein B100 of LDL suffers increased damage by glycation, oxidation, and nitration in patients with type 2 diabetes, including patients receiving metformin therapy.
A. Ceriello +25 more
core +3 more sources
Advanced Materials, EarlyView.ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac +7 more
wiley +1 more source
Apolipoprotein E Protects against NMDA Excitotoxicity
Neurobiology of Disease, 2002 Preclinical and clinical evidence implicates a role for endogenous apolipoprotein E in modifying the response of the brain to focal and global ischemia.
Mitsuo Aono +7 more
doaj
Apolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis [PDF]
Journal of Clinical and Diagnostic Research, 2013 Background & Objectives: Myocardial infarction and stroke are leading causes of death worldwide. Primarily, arteriosclerosis is responsible for these events. There is a strong family history suggesting a genetic cause.
P. D. Zende +3 more
doaj +1 more source
Correction of the neuropathogenic human apolipoprotein E4 (APOE4) gene to APOE3 in vitro using synthetic RNA/DNA oligonucleotides (chimeraplasts) [PDF]
, 2005 Apolipoprotein E (apoE) is a multifunctional circulating 34-kDa protein, whose gene encodes single-nucleotide polymorphisms linked to several neurodegenerative diseases.
Dickson, JG +3 more
core +1 more source
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source