Results 71 to 80 of about 25,315 (305)

Different Apolipoproteins Impact Nanolipoprotein Particle Formation

, 2016
Spontaneous interaction of purified apolipoproteins and phospholipids results in formation of lipoprotein particles with nanometer-sized dimensions; we refer to these assemblies as nanolipoprotein particles or NLPs.
Vicki L. Walsworth (2369560), Jenny A. Cappuccio (2427784), Brett A. Chromy (245886), Graham Bench (245888), Angie K. Hinz (2467030), Edward A. Kuhn (245887), Paul D. Hoeprich (245890), Matthew A. Coleman (131460), Henry Benner (2467018), Joseph B. Pesavento (2467027), Paul T. Henderson (847604), Todd A. Sulchek (262642), Erin Arroyo (2467024), Craig D. Blanchette (245880), Brent W. Segelke (245883), Ted Tarasow (2467021)   +15 more
core   +1 more source

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

Advanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du, Yinming Li, Ziyue Li, Yuedan Wang, Shaopeng Li, Yijie Wang, Yingying Qu, Bingyang Lv, Ying Li, Ting Chen, Yu Zhou, Xuan Xiao   +11 more
wiley   +1 more source

Major Lipids, Apolipoproteins, and Alterations of Gut Microbiota

, 2021
The gut microbiota has been linked to blood lipids. However, the relationship between the gut microbiome and other lipid markers like apolipoproteins A1 (apoA1) and B (apoB) as well as classical lipid markers in Asians remain unclear.
김형래
core   +2 more sources

Major lipids, apolipoproteins, and risk of vascular disease [PDF]

, 2009
Context: Associations of major lipids and apolipoproteins with the risk of vascular disease have not been reliably quantified. Objective: To assess major lipids and apolipoproteins in vascular risk.
Willeit J, Psaty BM, Danesh, J, Strandberg TE, Harald K, Tipping RW, Ebrahim S, Nakagawa H, Walldius G, Taylor J, Panagiotakos DB, Gómez-Gerique JA, Kromhout D, Thompson, S. G., Lappas G, Walker M, Bladbjerg, Else-Marie; id_orcid, Salonen JT, Chetrit A, Hedblad B, Shipley M, Yarnell JW, Rodeghiero F, Barrett Connor E, Benderly M, Donfrancesco C, Sarwar, Nadeem, He Y, Wennberg P, Blokstra A, Thompson, Simon, Fletcher A, Naito Y, Ray, K. K., Ray KK, Khaw KT, Tanne D, Pencina MJ, Marin Ibañez A, Stefanadis C, Sarwar, N., Casiglia E, Aspelund T, Mayr A, Ray, Kausik K., Ben Shlomo Y, Di Angelantonio, Emanuele, The Emerging Risk Factors Collaboration*, Sattar, Naveed, White IR, Panico S, Wald N, Jespersen, Jørgen; id_orcid, Danesh J., Dankner R, Lannfelt L, Orfei L, Sato S, Njølstad I, Poppelaars, J.L., Jousilahti P, Manson J, Tybjaerg Hansen A, Gómez Gerique JA, Nagel D, Nijpels G, Davey-Smith G, Friedlander Y, Mathiesen EB, Packard, Chris J, Pressel SL, Tavendale R, Brunner E, Barrett-Connor E, Thompson A, Kaptoge, S., Folsom AR, Sattar, N, Emerging Risk Factors Collaboration Di Angelantonio E, Emerging Risk Factors Collaboration, Nyyssönen K, Giedraitis V, Danesh, J., Nordestgaard BG, Wood, Angela M, Wensley F, Wood, A., Kardys I, Thompson, S.G., Kaptoge, S, Evans A, Kuller LH, Bas Bueno-de-Mesquita H, Meisinger C, Mraz W, Breteler M, Fowkes FG, Benn M, Wood, AM, Lawlor DA, Davey Smith G, Eriksson H, Chambless LE, Meade TW, Hankinson S, Lamarche B, Verschuren WM, Selmer R, Lewington, Sarah, Collins, R, Dekker, J.M., Perry, Philip, Wallace R, Knottenbelt C, Thompson SG, Tunstall Pedoe H, Lind L, Gallacher J, Witteman J, Ray, KK, Garcia Palmieri MR, Erqou S, Perry, P, Wood, A.M., Jørgensen T, Collins R, Dekker JM, Nietert PJ, Collins, R., Whincup PH, Di Angelantonio, E, Deeg, D.J.H., Lubin F, Marmot M, Schulte H, Diem G, Ben-Shlomo Y, Zhang Y, Raum E, Berglund G, Guralnik J, Arveiler D, Morris RW, Guralnik JM, Gaziano JM, Ridker P, Robertson M, Wingard DL, Sigurdsson G, Gudnason V, Jansson JH, Thorsson B, Tuomainen TP, Bachman DL, Møller L, Ford CE, Tunstall-Pedoe H, Packard, C. J., Onat A, Nissinen A, Wood, A. M., Tracy RP, Engstrom G, Nystad W, Thompson, Simon G, Umans J, Jouven X, Holme I, Stampfer M, Kaptoge, Stephen, Gómez de la Cámara A, Tilvis RS, Løchen ML, Bengtsson C, Ukendt, m.fl., Tosetto A, Brenner H, Jespersen J, Ray, R.R., Poppelaars JL, Rosengren A, Blazer DG, Miura K, Wannamethee SG, Buring J, Palmieri L, Salomaa V, Giampaoli S, Sattar, N., Nijpels, M.G.A.A.M., Sattar N, Shepherd J, Dagenais GR, Cobbe SM, Perry, P., Sarwar N, Crespo CJ, Best L, Stehouwer CD, Danesh, John, Hofman A, Packard, C.J., D'Agostino RB, Assmann G, Woodward M, Tikhonoff V, Bas Bueno de Mesquita H, Ducimetiere P, Cremer P, Packard, CJ, Knuiman M, Lewington S, Goldbourt U, Rimm E, Iso H, Döring A, Cooper JA, Ford I, Lewington, S, Rothenbacher D, Wilsgaard T, Watson S, Clarke R, PANICO, SALVATORE, Wood, Angela M., Thompson, Alexander, Thompson, A, Amouyel P, Ferrieres J, Howard BV, Kaptoge S, Verschure WM, Sarwar, N, Lewington, S., Vartiainen E, Wolf PA, Björkelund C, Gillum R, Müller H, Pilotto L, Després JP, Frikke Schmidt R, Perry PL, Noda H, Vasan RS, Phillips CL, Pitsavos C, Collaboration, Emerging Risk Factors, Wood AM, Bladbjerg EM, Ray, Kausik K, Kiechl S, Lee AJ, Di Angelantonio E, Collins, Rory, Thompson, A., Jungner I, Cantin B, Feskens EJ, Ingelsson E, Bauer KA, Ulmer H, Tverdal A, Frikke-Schmidt R, Chrysohoou C, Ray, K.K., Rodriguez B, Pennells L, Alexander M, Smith FB, Bettencourt R, Lowe GD, Santer P, Vanuzzo D, Concin H, Keil JE, Grandits G, McCallum J, Wilhelmsen L, Pai JK, Kitamura A, Cushman M, Trevisan M, Packard CJ, Koenig W, Di Angelantonio, E., Mussolino M, Sutherland SE, Thompson, SG, Simons L, Lissner L, Tybjaerg-Hansen A, Perry P, Deeg DJ, Packard, Chris J.   +294 more
core   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

Incorporation of Novel Synthetic Glycolipids in Liposomal Nanoparticles Affects Opsonization and In Vivo Clearance

Angewandte Chemie, EarlyView.
We prepared five glycosylated liposomal nanoparticles (G‐LNPs) to investigate the role of glycosylation and protein corona in modulating the in vivo behavior of G‐LNPs. We show that IgG and complement C3 adsorption enhanced liposomal nanoparticle clearance, with IgG promoting subsequent C3 binding.
Yingjie Yu, Xuehan Li, Yu Gao, Shijia Tao, Xiaofei Li, Lemei Zhao, Wenshuai Han, Hao Fan, Ying Qiu, Man Wang, Luying Zhou, Xiaoyan Fang, Wenhua Yang, Haiyang Zhang, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang, Xiangzhao Mao   +18 more
wiley   +2 more sources

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Abnormalities in lipoproteins of d < 1.006 g/ml in familial lecithin:cholesterol acyltransferase deficiency

Journal of Lipid Research, 1980
Studies of different sized lipoproteins of d < 1.006 g/ml from patients with familial lecithin:cholesterol acyltransferase deficiency have yielded new evidence of abnormalities in this lipoprotein class.
J A Glomset, K Applegate, T Forte, W C King, C D Mitchell, K R Norum, E Gjone   +6 more
doaj   +1 more source

Bacterial lipopolysaccharide forms aggregates with apolipoproteins in male and female rat brains after ethanol binges

Alcohol binge drinking allows the translocation of bacterial lipopolysaccharide (LPS) from the gut to the blood, which activates the peripheral immune system with consequences in neuroinflammation.
Escudero Moreno, Berta, López Valencia, Leticia, Orio Ortiz, Laura, Moya Montes, Marta, García Bueno, Borja   +4 more
core   +1 more source

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source