Results 81 to 90 of about 23,749 (264)

Lipoprotein metabolism in the ovariectomized rat.

Journal of Lipid Research, 1983
The hyperlipoproteinemia observed after ovariectomy in rats was previously shown to be associated with increased concentrations of cholesterol, triglycerides, and apolipoproteins B, E, and C.
B J van Lenten, G W Melchior, P S Roheim
doaj   +1 more source

Controllable Cascade Aggregation Ion Programmed Nanomachines and Simple Isolation Enable Tumor‐Derived Small Extracellular Vesicles Detection for Enhanced Breast Cancer Assessment

Advanced Science, EarlyView.
This study developed a convenient, enzyme‐free detection platform based on controllable aggregation ion nanomachines. Its favorable anti‐interference capacity and high sensitivity meet the detection requirements for clinical samples processed via a simple filtration method within 10 min.
Zhihao Zhang, Zijing Liu, Xiangyue Meng, Pengjun Jiang, Jie Qu, Yu Jiang, Binxu Qiu, Jie Chen, Piaopiao Chen   +8 more
wiley   +1 more source

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Genetic Influence of APOB XbaI Polymorphism on Eating Behaviors and Hematological Profiles in Depressed Adults: A Pilot Clinical Insight

Proceedings
Introduction: Lipid metabolism disturbances have been linked to depression pathophysiology, with apolipoprotein B (APOB)—a key component of LDL particles—emerging as a relevant biomarker [...]
Antonio A. F. Soares, Dante M. T. Teixeira, Alexandre S. R. Pereira, Alexandre P. Batista, Bruna F. M. Alencar, Calliandra M. S. Silva, Marcela M. G. Paes, Matheus G. Castro, Sophia T. T. Alves, Izabel C. R. Silva   +9 more
doaj   +1 more source

Human apolipoprotein B: analysis of internal repeats and homology with other apolipoproteins.

Journal of Lipid Research, 1987
Apolipoprotein B (apoB) is the major protein component of plasma low density lipoproteins (LDL) and, through its binding to the LDL receptor, it plays a prominent role in lipoprotein metabolism and in the development of atherosclerosis.
H De Loof, M Rosseneu, C Y Yang, W H Li, A M Gotto, Jr, L Chan   +5 more
doaj   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Both apolipoproteins B-48 and B-100 are synthesized and secreted by the human intestine

Journal of Lipid Research, 1990
Apolipoprotein B (apoB), an apolipoprotein associated with very low density lipoproteins and the atherogenic low density lipoproteins (LDL), directs the metabolism of lipoprotein particles in plasma by interacting with the LDL receptor.
JM Hoeg, DD Sviridov, GE Tennyson, SJ Demosky, Jr, MS Meng, D Bojanovski, IG Safonova, VS Repin, MB Kuberger, VN Smirnov   +9 more
doaj   +1 more source

Sex Differences in the Association of Simultaneous Decline in Blood Pressure and Decline in Cognition during Aging

Annals of Neurology, EarlyView.
Objective Both high and declining blood pressure (BP) are associated with risk of cognitive decline in older adults, and women have higher rates of hypertension and faster cognitive decline in late‐life. In old age, the relationship between changes in BP and changes in cognition is complex, and although sex differences in cognitive function and decline
Nicholas W. Baumgartner, Ana W. Capuano, Lisa L. Barnes, David A. Bennett, Zoe Arvanitakis   +4 more
wiley   +1 more source

Diabetes and the Metabolic Syndrome as Drivers of Neurodegeneration: Convergent Mechanisms Linking Peripheral Neuropathy and Dementia

Annals of Neurology, EarlyView.
The metabolic syndrome, a state of progressive metabolic dysfunction, injures the peripheral and central nervous systems, promoting peripheral neuropathy (PN) and cognitive impairment (CI), respectively. We posit PN and CI are connected in the metabolic syndrome framework, built on the premise that neurons, whether in the peripheral or central nervous ...
Masha G. Savelieff, David L. Bennett, Troels S. Jensen, Eva L. Feldman   +3 more
wiley   +1 more source