Results 211 to 220 of about 21,816 (261)

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus ...
R E, Pitas, J K, Boyles, S H, Lee, D, Foss, R W, Mahley   +4 more
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Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease

Ageing Research Reviews, 2009
The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
SERIPA D, PANZA F, FRANCESCHI M, D'ONOFRIO G, DALLAPICCOLA B, PILOTTO A., SOLFRIZZI, Vincenzo   +6 more
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Apolipoprotein E polymorphism and gallstones

Gastroenterology, 1996
Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
A, Bertomeu, E, Ros, D, Zambón, M, Vela, R M, Pérez-Ayuso, E, Targarona, M, Trías, C, Sanllehy, E, Casals, J M, Ribó   +9 more
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Molecular biology of apolipoprotein E

Current Opinion in Lipidology, 2002
Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein.
Warren J, Strittmatter, Carol, Bova Hill
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Apolipoprotein E genotype and psychosis

Biological Psychiatry, 1997
Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD).
R, Igata-Yi, T, Igata, K, Ishizuka, T, Kimura, S, Sakamoto, S, Katsuragi, J, Takamatsu, T, Miyakawa   +7 more
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Apolipoprotein E levels in vegetarians

Metabolism, 1982
Vegetarians are known to have low lipoprotein lipid and apolipoprotein Al and B levels. Since dietary cholesterol has recently been shown to have important effects on apolipoprotein E (apo E) metabolism, we measured plasma apo E levels in three groups of vegetarians. Group I (n = 36) consumed less than 10 mg cholesterol daily and 42% of calories as fat
D R, Lock, A, Varhol, S, Grimes, W, Patsch, G, Schonfeld   +4 more
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ApolipoproteinE and Alzheimer's Disease

Biochemical Society Transactions, 1996
Abstract: The specific molecular pathway by which apolipoprotein E modifies the expression of Alzheimer's disease remains elusive. Isoform‐ specific interactions of apolipoprotein E with other molecules determine the outcome from other neurologic disorders and may provide more tractable model systems.
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Apolipoprotein E

Molecular and Cellular Biochemistry, 1982
V I, Zannis, J L, Breslow
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Apolipoprotein E and cholesterol metabolism

Klinische Wochenschrift, 1983
The role of apo-E in mediating lipoprotein interaction with specific receptors has been established. Through the use of selective chemical modification of specific amino acid residues of certain lipoproteins, we have gained insight into the importance of the lysine and arginine residues in this process. This understanding has been expanded by structure-
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Apolipoprotein E and Alzheimer disease

Neurology, 2006
Apolipoprotein (apo) E, a multifunctional protein with central roles in lipid metabolism and neurobiology, has three common isoforms (apoE2, apoE3, and apoE4) with different effects on lipid homeostasis and neurobiology. Unlike apoE3, the most common isoform, apoE4, is associated with increased risk of developing Alzheimer disease (AD) and other ...
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