Results 251 to 260 of about 37,409 (305)

Genotyping of Apolipoprotein E

2003
Apolipoprotein E (apo E) is a 299-amino acid plasma protein involved in cholesterol transport and is found in chylomicrons, very low density lipopro-tein, intermediate-density lipoprotein, and high-density lipoprotein (1,1).
I C, Ozturk, N, Akel, A A, Killeen
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Apolipoprotein E in neurology

Current Opinion in Neurology, 1996
Apolipoprotein E became relevant for neurologists in 1993 when the association of the apolipoprotein E-epsilon 4 allele with familial and sporadic late-onset Alzheimer disease was reported. Since that time, more than 100 confirmations and many research papers have appeared.
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Apolipoprotein in E in Myasthenia Gravis

Annals of the New York Academy of Sciences, 1998
It is believed that apo E may moderate T lymphocytes by activation of mitogens or antigens. In that way, it has an influence on immune processes and it is reasonable to study the relationship between apo E genotypes and myasthenia gravis phenotypes. We tried to find any feature connected to the development of a different intensity of myasthenia gravis.
Šoštarko, Marija, Sertić, Jadranka, Gregurić, A, Stavljenić Rukavina, Ana, Brzović, Zdravko, Matić, Vesna   +5 more
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Apolipoprotein E

2013
For the past two decades the epsilon 4 (ε4) allele of the Apolipoprotein E (APOE) gene has remained the only well established and greatest genetic risk factor for late-onset Alzheimer's disease (LOAD). ApoE is a 299-amino acid, 34.2 kDa, glycoprotein that has been implicated in multiple biological functions which will be described in this chapter ...
Carrasquillo, Minerva M., Bu, Guojun, Nielsen, Henrietta M.   +2 more
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Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1987
We have previously demonstrated that astrocytes synthesize and secrete apolipoprotein E in situ. In the present work, primary cultures of rat brain astrocytes were used to study apolipoprotein E synthesis, secretion, and metabolism in vitro. The astrocytes in culture contained immunoreactive apolipoprotein E in the area of the Golgi apparatus ...
R E, Pitas, J K, Boyles, S H, Lee, D, Foss, R W, Mahley   +4 more
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Non-apolipoprotein E and apolipoprotein E genetics of sporadic Alzheimer's disease

Ageing Research Reviews, 2009
The genetic epidemiology of sporadic Alzheimer's disease (SAD) remains a very active area of research,making it one of the most prolifically published areas in medicine and biology. Numerous putative candidate genes have been proposed. However, with the exception of apolipoprotein E (APOE), the only confirmed genetic risk factor for SAD, all the other ...
SERIPA D, PANZA F, FRANCESCHI M, D'ONOFRIO G, DALLAPICCOLA B, PILOTTO A., SOLFRIZZI, Vincenzo   +6 more
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Apolipoprotein E polymorphism and gallstones

Gastroenterology, 1996
Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
A, Bertomeu, E, Ros, D, Zambón, M, Vela, R M, Pérez-Ayuso, E, Targarona, M, Trías, C, Sanllehy, E, Casals, J M, Ribó   +9 more
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Molecular biology of apolipoprotein E

Current Opinion in Lipidology, 2002
Apolipoprotein E, first identified 26 years ago as a serum protein that mediates extracellular cholesterol transport, is now known to regulate multiple additional metabolic pathways. Several clinically important disorders of the vasculature and brain are differentially caused, or modified, by the three isoforms of this protein.
Warren J, Strittmatter, Carol, Bova Hill
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Apolipoprotein E genotype and psychosis

Biological Psychiatry, 1997
Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD).
R, Igata-Yi, T, Igata, K, Ishizuka, T, Kimura, S, Sakamoto, S, Katsuragi, J, Takamatsu, T, Miyakawa   +7 more
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Apolipoprotein E levels in vegetarians

Metabolism, 1982
Vegetarians are known to have low lipoprotein lipid and apolipoprotein Al and B levels. Since dietary cholesterol has recently been shown to have important effects on apolipoprotein E (apo E) metabolism, we measured plasma apo E levels in three groups of vegetarians. Group I (n = 36) consumed less than 10 mg cholesterol daily and 42% of calories as fat
D R, Lock, A, Varhol, S, Grimes, W, Patsch, G, Schonfeld   +4 more
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