Results 101 to 110 of about 26,023 (245)

Gender disparity in access to advanced therapies for patients with Parkinson’s disease: a retrospective real-word study

Frontiers in Neurology
BackgroundGender differences in the access to advanced therapies for Parkinson’s disease (PD) are poorly investigated.ObjectiveThe objective of this study was to investigate the presence of any gender disparity in the access to advanced therapies for PD ...
Giuseppe Maccarrone, Gennaro Saporito, Patrizia Sucapane, Chiara Rizi, Federico Bruno, Alessia Catalucci, Maria Letizia Pistoia, Alessandra Splendiani, Alessandro Ricci, Ernesto Di Cesare, Marina Rizzo, Rocco Totaro, Francesca Pistoia, Francesca Pistoia   +13 more
doaj   +1 more source

Repeated Intrastriatal Botulinum Neurotoxin-A Injection in Hemiparkinsonian Rats Increased the Beneficial Effect on Rotational Behavior

Toxins, 2018
Injection of botulinum neurotoxin-A (BoNT-A) into the striatum of hemiparkinsonian (hemi-PD) rats reduced apomorphine-induced rotation behavior significantly, for at least 3 months. Thereafter, rotation behavior increased again.
Alexander Hawlitschka, Carsten Holzmann, Andreas Wree, Veronica Antipova   +3 more
doaj   +1 more source

1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine （MPTP） ユウハツ イッソクセイ サル パーキンソンビョウ モデル ノ カクリツ [PDF]

, 2009
背景:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)を用いてパーキンソン病モデルサルを作製する場合、その効果には個体差が大きいことが問題となる。そのため作製したモデル動物がパーキンソン病様の病態を示しているかどうかは、脳の病理組織学的検査と線条体のドーパミン量から判断する必要がある。しかし作製した病態モデル動物を治療薬の開発に用いるためには、生きた動物を信頼性の高い客観的方法によって評価する必要がある。本研究は ...
大和田 一雄, 藤井 雅典, 藤井 順逸   +2 more
core   +1 more source

The Management of Parkinson's Disease Before, during and after Pregnancy—an MDS Scientific Issues Committee Review

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 44-59, January 2026.
Abstract Background Pregnancy after a Parkinson's diagnosis presents complex challenges. Due to the paucity of literature, there is no evidence‐based guidelines and protocols for preconception care, management of pregnancy, childbirth and the postpartum period in women with early‐onset Parkinson's disease (PD).
Alexander C. Lehn, Jee‐Young Lee, Giorgia Sciacca, Stacy Patterson, Adam Morton, Paul Pun, Walaa A. Kamel, Marina Picillo, Bart Post, Eng‐King Tan, Tamine Capato, Bastiaan R. Bloem, Manon Auffret, Annelien M. Oosterbaan, Willanka Kapelle, Michiko K. Bruno, Lorraine V. Kalia, Jeffrey H. Kordower, Daniela Berg   +18 more
wiley   +1 more source

The Influence of Genetics in the Early Development of Axial Postural Abnormalities in Parkinson's Disease

Movement Disorders Clinical Practice, Volume 13, Issue 1, Page 230-235, January 2026.
ABSTRACT Background Postural abnormalities (PA) can complicate Parkinson's disease (PD). While age and motor severity are established predictors, the genetic role remains underexplored. Objective To evaluate the influence of major genetic variants on PA development in PD over 4 years.
Ilaria A. Di Vico, Silvia Gallo, Eleonora Bertoncello, Claudia Ledda, Michele Tinazzi, Leonardo Lopiano, Carlo Alberto Artusi   +6 more
wiley   +1 more source

Further Insights Into Anticholinergic Action Informed by Japanese Anticholinergic Risk Scale

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT The increased anticholinergic burden caused by medications in older adults is one of the adverse drug reactions of particular concern, as it can exacerbate the onset of geriatric syndromes or induce cognitive dysfunction, and is also related to the issue of polypharmacy.
Masaki Mogi, Shuang Liu, Yasuyuki Suzuki, Yuuka Shibata, Shizuo Yamada   +4 more
wiley   +1 more source

What's a brain: neuroanatomy and neurochemistry of anxiety disorders in dogs [PDF]

, 2011
This review deals with the neurocircuitry of fear and anxiety disorders, with the focus on neuroanatomy and neurochemistry. This knowledge is required to correctly diagnose and treat dogs with anxiety-related behavioral disorders.
Audenaert, Kurt, De Meester, Rudy, Dobbeleir, André, Peremans, Kathelijne, van Bree, Henri, Vandermeulen, Eva, Vermeire, Simon   +6 more
core   +1 more source

Synergistic Effects of Levodopa, Benserazide, and Nortriptyline on Behavioral Impairments and Brain Pathology in an Experimental Rat Model of Parkinson’s Disease

Neurology Research International, Volume 2026, Issue 1, 2026.
Background Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). In addition to postural instability, rigidity, tremor, and bradykinesia, patients will experience depression and/or anxiety at any time during PD.
Maryam Ezzedin, Sam Zarbakhsh, Houman Parsaei, Ali Ghanbari, Abbas Ali Vafaei, Zohre Mohsenvand, Seyed Ali Seyedinia, Parnia Tarahomi, Manouchehr Safari, Rita Chiaramonte   +9 more
wiley   +1 more source

Non-Targeted Metabolomics Reveal Apomorphine’s Therapeutic Effects and Lysophospholipid Alterations in Steatohepatitis

Antioxidants
Metabolic dysfunction-associated steatohepatitis (MASH), characterized by progressive inflammation and fibrosis, evolves from metabolic dysfunction-associated steatotic liver disease and significantly heightens the risk of cirrhosis and hepatocellular ...
Hideo Ogiso, Kouichi Miura, Ryozo Nagai, Hitoshi Osaka, Kenichi Aizawa   +4 more
doaj   +1 more source

Long-term safety and efficacy of apomorphine infusion in Parkinson's disease patients with persistent motor fluctuations: Results of the open-label phase of the TOLEDO study [PDF]

, 2021
Regina Katzenschlager, Werner Poewe, Olivier Rascol, Claudia Trenkwalder, Günther Deuschl, К. Ray Chaudhuri, Tove Henriksen, Teus van Laar, Donna Lockhart, Harry Staines, Andrew J. Lees   +10 more
openalex   +1 more source