BMC Complementary and Alternative Medicine, 2017 Background The hydro-ethanolic whole plant extract of Synedrella nodiflora (SNE) has demonstrated anticonvulsant, sedative and analgesic effects. Preliminary studies conducted in animals, SNE significantly decreased stereotypic behaviours suggesting ...
Patrick Amoateng +6 more
doaj +1 more source
Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers. [PDF]
PLoS ONE, 2013 The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter ...
Roi Treister +3 more
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Implanted Reuptake-deficient or Wild-type Dopaminergic Neurons Improve ON L-dopa Dyskinesias Without OFF-dyskinesias in a Rat Model of Parkinson's Disease [PDF]
, 2012 OFF-L-dopa dyskinesias have been a surprising side-effect of intrastriatal foetal ventral mesencephalic transplantation in patients with Parkinson's disease.
Caron, M. G. +7 more
core +1 more source
Journal of Veterinary Pharmacology and Therapeutics, EarlyView.ABSTRACT The ATP‐binding cassette transporter MDR1 P‐glycoprotein (syn. ABCB1) is an efflux carrier at the cell membrane that regulates drug absorption, distribution, and elimination. At the blood–brain barrier, MDR1 restricts brain entry of potentially neurotoxic drugs, such as ivermectin. In dogs and cats, MDR1 (syn.
Lisa Siegl +6 more
wiley +1 more source
Evaluation of Antipsychotic Activity of Ethanolic Bark Extract of Myrica esculenta in Rats
Pharmaceutical Sciences and Research, 2020 The antipsychotic properties of Myrica esculenta stem bark were evaluated. The stem bark was collected, shade dried, and pulverized. Extraction was carried out with 70% ethanol by occasional shaking. Preliminary phytochemical screening of the extract was
Biswash Sapkota +3 more
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Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease [PDF]
, 2018 Several neurotrophic factors ( NTF) are shown to be neuroprotective and neurorestorative in pre-clinical animal models for Parkinson's disease ( PD), particularly in models where striatal dopamine neuron innervation partially exists.
Airavaara, Mikko +10 more
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Apomorphine is a potent inhibitor of ferroptosis independent of dopaminergic receptors
Scientific ReportsOriginally, apomorphine was a broad-spectrum dopamine agonist with an affinity for all subtypes of the Dopamine D1 receptor to the D5 receptor. We previously identified apomorphine as a potential therapeutic agent for mitochondrial diseases by screening ...
Akihiko Miyauchi +13 more
doaj +1 more source
Apomorphine-induced disruption of prepulse inhibition that can be normalised by systemic haloperidol is insensitive to clozapine pretreatment [PDF]
, 2018 Rationale: Prepulse inhibition (PPI) of startle refers to the phenomenon in which a weak prepulse attenuates the startle response to a succeeding intense stimulus.
Durkin, S. +4 more
core
A New Phenotype–Genotype Correlation for FIG4 and Parkinson's Disease
Movement Disorders Clinical Practice, EarlyView.
Iro Boura +4 more
wiley +1 more source
Brain and Behavior, Volume 16, Issue 2, February 2026.In Parkinson's disease, the death of dopamine neurons in the substantia nigra, resulting in a decrease in dopamine levels in the striatum. This leads to striatal damage through the HMGB1/RAGE/NF‐κB signaling pathway, thereby inducing motor and cognitive dysfunction.
Yaofeng Zhu +7 more
wiley +1 more source