Results 61 to 70 of about 63,014 (274)

Loss of Tripartite Motif–Containing Protein 21 and UVB‐Induced Systemic Inflammation by Regulating DNA‐Sensing Pathways

open access: yesArthritis &Rheumatology, Volume 78, Issue 1, Page 172-183, January 2026.
Objective Patients with systemic lupus erythematosus (SLE) experience photosensitivity, with exposure to UVB light driving lupus flares and triggering symptoms like joint pain, fatigue, and cutaneous lesions. Although the mechanism(s) linking UVB exposure to systemic effects are unclear, type I interferons (IFNs) are known to play a role.
Gantsetseg Tumurkhuu   +17 more
wiley   +1 more source

Biochemical evaluation of focal non-reperfusion cerebral ischemia by middle cerebral artery occlusion in rats Avaliação bioquímica da isquemia cerebral focal, não associada à reperfusão, por oclusão da artéria cerebral média em ratos

open access: yesArquivos de Neuro-Psiquiatria, 2008
Cerebral ischemia is an important event in clinical and surgical neurological practice since it is one of the diseases that most compromise the human species. In the present study 40 adult rats were submitted to periods of focal ischemia of 30, 60 and 90
Benedicto Oscar Colli   +4 more
doaj   +1 more source

Entwicklung und funktionelle Charakterisierung rekombinanter Formen der pro-apoptotischen Enzyme Granzym B und Caspase-3 zur gezielten Induktion des programmierten Zelltods in Tumorzellen [PDF]

open access: yes, 2004
Zytotoxische T-Lymphozyten und natürliche Killer-Zellen sind hochspezialisierte Zellen des Immunsystems, die durch Sekretion der Serin-Protease Granzym B (GrB) und des membranolytischen Proteins Perforin Virusinfizierte, körperfremde oder auch ...
Giesübel, Ulrike
core  

Advancing Mechano‐Bactericidal Surfaces: Mechanisms, Fabrication, and Synergistic Antimicrobial Strategies

open access: yesAdvanced Materials Interfaces, Volume 12, Issue 23, December 8, 2025.
This review provides a detailed introduction to the fabrication and modulation of nanostructured mechano‐bactericidal surfaces and emphasizes integration of photoactive materials, chemical biocides, stimuli‐responsive self‐cleaning coatings, and electro‐mediated strategies to achieve multifunctional and synergistic antimicrobial effects, providing ...
Yiwen Zhong   +8 more
wiley   +1 more source

Identifizierung eines Moleküls, das den Abbau der aktivierten Checkpoint‐Kinase‐1 auslöst und Charakterisierung der nicht‐katalytischen Funktionen von Checkpoint‐Kinase‐1 in Tumorzellen

open access: yesAngewandte Chemie, Volume 137, Issue 49, December 1, 2025.
In Tumorzellen führt die durch HU induzierte Verlangsamung der DNA‐Replikation zur Aktivierung von CHK1 durch Autophosphorylierung, was einen Zellzyklusarrest bewirkt und die Rekrutierung des DNA‐Reparaturproteins WRN zur Förderung der DNA‐Reparatur und des Zellüberlebens ermöglicht.
Ramy Ashry   +13 more
wiley   +1 more source

Calcium and cell death signaling in neurodegeneration and aging

open access: yesAnais da Academia Brasileira de Ciências, 2009
Transient increase in cytosolic (Cac2+) and mitochondrial Ca2+ (Ca m2+) are essential elements in the control of many physiological processes. However, sustained increases in Ca c2+ and Ca m2+ may contribute to oxidative stress and cell death.
Soraya Smaili   +10 more
doaj   +1 more source

S1‐Leitlinie für bildgebende Diagnostik von Hauterkrankungen

open access: yesJDDG: Journal der Deutschen Dermatologischen Gesellschaft, Volume 23, Issue 12, Page 1616-1632, December 2025.
Zusammenfassung Nichtinvasive Bildgebungstechniken erlauben schnell und schmerzfrei diagnostische Blicke in die Haut, je nach angewandter Methode mit unterschiedlich hoher Auflösung und Eindringtiefe. Schon seit Jahrzehnten aus dem Alltag nicht wegzudenken sind die etablierten Untersuchungsmethoden wie die Dermatoskopie und die hochauflösende ...
Maximilian Deußing   +21 more
wiley   +1 more source

Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters

open access: yesAnais da Academia Brasileira de Ciências, 2009
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a ...
Alexandre Kanashiro   +6 more
doaj   +1 more source

India ink induces apoptosis in the yellow clam Mesodesma mactroides (Deshayes, 1854). Optical and ultrastructural study

open access: yesAnais da Academia Brasileira de Ciências, 2015
This paper reports on the acute inflammatory and cellular process in the yellow clam, Mesodesma mactroides, induced by injection of India ink into the muscular foot.
YURI B.M. CARVALHO   +3 more
doaj   +1 more source

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