Results 61 to 70 of about 64,094 (275)

Untersuchung der Adressierbarkeit des Cysteinoms der Proteinkinasen durch Kovalente Fragmente

Angewandte Chemie, Volume 137, Issue 8, February 17, 2025.
Trotz umfangreicher Forschungsarbeiten an kovalenten Kinaseinhibitoren bleibt ein Großteil des „Cysteinoms“ der Proteinkinasen unerforscht. Hier skizzieren wir einen verallgemeinerbaren Ansatz zur Adressierung von Cysteinen der ATP‐Bindetasche mit fragmentartigen kovalenten Inhibitoren.
Guiqun Wang, Nico J. Seidler, Sandra Röhm, Yufeng Pan, Xiaojun Julia Liang, Lisa Haarer, Benedict‐Tilman Berger, Saran Aswathaman Sivashanmugam, Valentin R. Wydra, Michael Forster, Stefan A. Laufer, Apirat Chaikuad, Matthias Gehringer, Stefan Knapp   +13 more
wiley   +1 more source

Effect of linear energy transfer (LET) on complexity of alpha-particle-induced chromosome aberrations in human CD34+ cells. [PDF]

, 2007
The aim of this study was to assess the relative influence of linear energy transfer (LET) of α-particles on chromosome aberration complexity in the absence of significant other track structure differences.
Anderson, RM, Goodhead, DT, Hill, MA, Stevens, DL, Sumption, ND, Tounsend, KMS   +5 more
core  

Neuroprotektion und Aktivierung von Neurotrophin-Signaltransduktionswegen durch Hemmung von Protein-Tyrosin-Phosphatasen und durch NO-Donatoren [PDF]

, 2004
Trotz des enormen Fortschrittes der Medizin und neuen Erkenntnissen über die pathologischen Mechanismen des neuronalen Zelltodes steht bislang keine wirkungsvolle, kausale Therapie zur Behandlung neurodegenerativer Erkrankungen zur ...
Gerling, Norbert, Krieglstein, Josef (Prof. Dr. Dr.)   +1 more
core   +1 more source

Efeito do Plasma Rico em Plaquetas na apoptose pós-traumática de condrócitos

, 2011
OBJECTIVE: To evaluate if the injection of intra-articular platelet-rich plasma (PRP) can reduce impact-induced chondrocyte apoptosis. METHODS: A double-blind experimental study was developed in four knees of two adult rabbits.
M. U. Rezende, Ronald Bispo Barreto da Silva, A. Bassit, N.H. Tatsui, David Sadigursky, R. B. Neto   +5 more
semanticscholar   +1 more source

Caspase-3 activation and increased procollagen type I in irradiated hearts

Anais da Academia Brasileira de Ciências, 2013
The caspase-3-cleaved presence was evaluated in this study in the heart of irradiated rats, during the decline of ventricular function. Female Wistar rats were irradiated with a single dose of radiation (15 Gy) delivered directly to the heart and the ...
Samara C. Ferreira-Machado, Camila Salata, Nazareth N. Rocha, Alexandre F.S. Corrêa, Suzana Côrte-Real, Antônio A.F. Peregrino, Vera M.A. de Campos, Cherley B.V. Andrade, Mario Bernardo-Filho, Januário B. Cabral-Neto, Carlos E. Dealmeida   +10 more
doaj   +1 more source

Chaperon‐Abgeleitete Kupfer(I)‐Bindende Peptidnanofibrillen stören die Kupferhomöostase in Krebszellen

Angewandte Chemie, Volume 136, Issue 51, December 16, 2024.
Wir präsentieren ein von Chaperonen abgeleitetes Cu+‐bindendes Peptid, das das konservierte MTCGGC−Cu+‐Bindungsmotiv enthält und sich innerhalb von Krebszellen zu Nanofibrillen selbstassembliert. Diese Nanofibrillen besitzen mehrere MTCGGC−Cu+‐Bindungsmotive auf ihrer Oberfläche, wodurch eine effiziente Bindung intrazellulärer Cu+‐Ionen ermöglicht wird.
M. T. Jeena, Julian Link, Jian Zhang, Iain Harley, Petri Turunen, Robert Graf, Manfred Wagner, Luis Andre Baptista, Hendrik R. A. Jonker, Liyang Cui, Ingo Lieberwirth, Katharina Landfester, Jianghong Rao, David Y. W. Ng, Tanja Weil   +14 more
wiley   +1 more source

Expressão de marcadores de proliferação celular e apoptose no carcinoma espinocelular de pele e ceratose actínica

, 2009
BACKGROUND: Skin cancer is the most frequent type of human cancer and has shown an increase in its incidence. In many cases, before the onset of the carcinoma, there might be a precursor lesion - actinic keratosis, which can develop into squamous cell ...
Marilho Tadeu Dornelas, Michele Fernandes Rodrigues, Dequitier Carvalho Machado, Â. M. Gollner, A. Ferreira   +4 more
semanticscholar   +1 more source

Understanding the mechanisms of glutamine action in critically ill patients

Anais da Academia Brasileira de Ciências, 2010
Glutamine (Gln) is an important energy source and has been used as a supplementary energy substrate. Furthermore, Gln is an essential component for numerous metabolic functions, including acid-base homeostasis, gluconeogenesis, nitrogen transport and ...
Gisele P. Oliveira, Cristina M. Dias, Paolo Pelosi, Patricia R.M. Rocco   +3 more
doaj   +1 more source

Chemisch stabile Diazopeptide als selektive Sonden für Cysteinproteasen in lebenden Zellen

Angewandte Chemie, Volume 136, Issue 49, December 2, 2024.
Die Diazogruppe ist aufgrund ihrer selektiven und vielfältigen Reaktivität ein interessantes Werkzeug in der medizinischen Chemie und chemischen Biologie. Wir zeigen, dass chemisch stabile Diazopeptide, die sogar 95 % Trifluoressigsäure standhalten, hergestellt und als hochpräzise chemische Instrumente eingesetzt werden können.
Juliane Wahl, Ahsanullah, Hana Zupan, Franziska Gottschalk, Andreas Nerlich, Christoph Arkona, Andreas C. Hocke, Bettina G. Keller, Jörg Rademann   +8 more
wiley   +1 more source

Proliferação de linfócitos e apoptose de células CD5+ de bovinos infectados pelo vírus da leucose enzoótica bovina

, 2011
The purpose of the present trail was to evaluate the lymphocyte proliferation and the apoptosis rates of CD5+ cells in dairy cows infected with bovine leukemia virus (BLV) with distinct lymphocyte profiles in infected animals known as alymphocytotic (AL)
F. N. Souza, Andréia Oliveira Latorre, Beatriz Dorr Caniceiro, M. Sakai, Karin Kieling, M. G. Blagitz, A. D. Libera   +6 more
semanticscholar   +1 more source