Results 251 to 260 of about 2,361,281 (339)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

RSL3 promotes PARP1 apoptotic functions by distinct mechanisms during ferroptosis. [PDF]

Cell Mol Biol Lett
Chen D, Xie F, Mo Y, Qin D, Zheng B, Chen L.   +5 more
europepmc   +1 more source

Evidence for early induction of calmodulin gene expression in lymphocytes undergoing glucocorticoid-mediated apoptosis.

, 1991
Diane R. Dowd, Paul N. MacDonald, Barry S. Komm, Mark R. Haussler, Roger L. Miesfeld   +4 more
openalex   +1 more source

A protein produced by a monocytic human cell line can induce apoptosis on tumor cells [PDF]

, 1994
Lina Ghibelli, Simona Coppola, C. Nosseri, Alberto Bergamini, Simone Beninati   +4 more
openalex   +1 more source

LIN28B Promotes Cancer Cell Dissemination and Angiogenesis

Advanced Biology, EarlyView.
Children diagnosed with high‐risk neuroblastoma have a 5‐year event‐free survival rate of less than 50% and poor outcomes after recurrence. Deregulation of the LIN28B oncogene can be addressed in these patients. Upregulation of LIN28B is shown to support the metastatic cascade.
Diana Corallo, Sara Menegazzo, Marcella Pantile, Silvia Bresolin, Carlo Zanon, Alessandro Davini, Massimiliano Mazzone, Alessandra Biffi, Sanja Aveic   +8 more
wiley   +1 more source

Oxidative stress-mediated apoptosis via the <i>SLC23A2</i>-ascorbic acid interaction contributes to cleft lip development. [PDF]

Front Pediatr
Yin B, Xu YC, Lu Y.
europepmc   +1 more source

The c-kit ligand suppresses apoptosis of human natural killer cells through the upregulation of bcl-2.

, 1994
William E. Carson, Subrata Haldar, Robert A. Baiocchi, Carlo M. Croce, M. A. Caligiuri   +4 more
openalex   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Deubiquitinating enzyme USP42 promotes breast cancer progression by inhibiting JNK/p38-mediated apoptosis. [PDF]

Sci Rep
He C, Chen J, Tian R, Yang L, He W, He L, Xu J, Li J, Wang G, Jiang C, Liu Q, Wan X, Yu T.   +12 more
europepmc   +1 more source

Adipose Mesenchymal Stem Cell‐Derived Exosomes in Conjunction with Roflumilast Ameliorate Chronic Kidney Disease Through the Modulation of Fibrosis and Inflammation

Advanced Biology, EarlyView.
The novelty of this study showed that the injection of exosomes produced from ADMSCs in combination with Roflumilast poses a more favorable therapeutic outcome for CKD induced by Adriamycin, compared to therapy with exosomes or Roflumilast alone. Roflumilast and exosomes treatment lowered the expression of the apoptotic, fibrotic, and inflammatory ...
Mohamed Ali, Mohamed H. Sherif, Nashwa Barakat, Bassant Yahia, Ahmed A. Shokeir, Basel Sitohy   +5 more
wiley   +1 more source