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Apoptosis

The American Journal of Surgical Pathology, 1997
Reading this article will introduce the reader to the basic concept of physiologic cell death referred to as apoptosis. In addition, the role of apoptosis in immune function as well as its contribution to various clinical disorders will be developed.The author's experience with recently described patients who have a unique autoimmune syndrome ...
Cummings, MC, Winterford, CM, Walker, NI
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Thymocyte Apoptosis

Journal of Clinical Immunology, 1999
Apoptosis is the fate of most thymocytes. Many molecules participate in the decision of whether a thymocyte is to live or to die, including cell surface receptors, such as the T cell receptor for antigen, Notch-1, and costimulatory receptors, ligand-regulated nuclear transcription factors such as the glucocorticoid receptor, signaling, and effector ...
Y, Yang, J D, Ashwell
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Proinflammatory apoptosis

Science Signaling, 2023
Apoptotic cells that cannot be expelled from the epithelium provoke inflammation by releasing ATP.
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Epithelial apoptosis

BioEssays, 1997
AbstractApoptosis is an essential part of the normal cellular phenotype repertoire. In the absence of appropriate survival factors, apoptosis is activated through specific signalling cassettes. Epithelia form distinctive three‐dimensional cohesive structures that depend on adhesive interactions in order for these tissues to carry out their specialised ...
Metcalfe, Anthony, Streuli, C.H.
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Apoptosis

Immunology Today, 1993
Cell death can be accidental or programmed in a multicellular organism. Evidence supports the proposition that there is a 'suicide program' inherent in vertebrate cells which can be activated when the cell's death is desirable for the good of the rest of the community.
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Apoptosis Assays

2006
A large number of methods devoted to the identification of apoptotic cells and the analysis of the morphological, biochemical, and molecular changes that take place during this universal biological process have been developed. Apoptotic cells are recognized on the basis of their reduced DNA content and morphological changes that include nuclear ...
Marcela, Oancea   +3 more
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Apoptosis Signaling

Annual Review of Biochemistry, 2000
▪ Abstract  Apoptosis, a physiological process for killing cells, is critical for the normal development and function of multicellular organisms. Abnormalities in cell death control can contribute to a variety of diseases, including cancer, autoimmunity, and degenerative disorders.
A, Strasser, L, O'Connor, V M, Dixit
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Surviving apoptosis

Apoptosis, 2002
The concept that cells subjected to chromatin cleavage during apoptosis are destined to die is being challenged. The execution phase of apoptosis is characterized by the activation of effector caspases, such as caspase-3, that cleave key regulatory or structural proteins and in particular activate apoptotic nucleases such as the caspase activated ...
A T M, Vaughan   +2 more
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Liver apoptosis

Journal of Hepatology, 1997
Apoptosis, also called programmed cell death, is a peculiar form of cell death different from cell necrosis in many morphological and biochemical aspects. Like mitosis or differentiation, apoptosis is a normal cell phenomenon which depends on the expression of genes capable of inducing or inhibiting this type of cell destruction. But apoptosis can also
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Hepatocyte Apoptosis

2009
Apoptosis has been documented as a frequent hurdle phenomenon that occurs in human hepatocytes during isolation, storage, infusion and after engraftment within the recipient liver parenchyma. Apoptosis is an active form of cell death that involves programmed cellular machineries leading to a progressive self-destruction of the cell.
Mustapha, Najimi   +2 more
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