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APOPTOSIS. THE ROLE OF APOPTOSIS IN CANCERS
, 2023 Apoptosis is a complex mechanism that is involved at any stage during organism development or in cellular damage. It is triggered by specific external and internal factors such as ultraviolet radiation, hypoxia, growth factors, viruses, and bacteria, which activate the two main pathways: the extrinsic pathway, also known as the death receptor pathway ...
Orlov Alina, Dumitraș Grigore
openaire +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells
Leukemia Research Reports, 2014 The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations.
Denis V. Baev +3 more
doaj +1 more source
The Drosophila Inhibitor of Apoptosis (IAP) DIAP2 Is Dispensable for Cell Survival, Required for the Innate Immune Response to Gram-negative Bacterial Infection, and Can Be Negatively Regulated by the Reaper/Hid/Grim Family of IAP-binding Apoptosis Inducers [PDF]
, 2007 Many inhibitor of apoptosis (IAP) family proteins inhibit apoptosis. IAPs contain N-terminal baculovirus IAP repeat domains and a C-terminal RING ubiquitin ligase domain.
Chen, Chun Hong +8 more
core
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway
eLife, 2013 Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same ...
Ainhoa Pérez-Garijo +2 more
doaj +1 more source
Quantitative assessment of cell fate decision between autophagy and apoptosis [PDF]
, 2017 Autophagy and apoptosis are cellular processes that regulate cell survival and death, the former by eliminating dysfunctional components in the cell, the latter by programmed cell death.
Bahar, Ivet +6 more
core +3 more sources
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Advances in Lung Stem Cells and Lung Cancer Stem Cells
Chinese Journal of Lung Cancer, 2015 Cancer stem cells (CSCs) are emerging as a hot topic for cancer research. Lung CSCs share many characteristics with normal lung stem cells (SCs), including self-renewal and multi-potency for differentiation.
Huijing YIN, Jiong DENG
doaj +1 more source
BioTechniques, 2013 The genetic transformation of target cells is a key tool in modern biological research, as well as in many gene therapy and biotechnology applications. Here we describe a new method for delivery of DNA into several industrially important species of yeast,
Yevhen Filyak +7 more
doaj +1 more source