Results 51 to 60 of about 2,974,203 (387)

Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy

Nature Communications, 2018
IRE1/XBP-1 activation has a major role in Triple negative breast cancer (TNBC). Here, the authors show that inhibition of IRE1’s RNase activity attenuates autocrine and paracrine signaling of pro-tumorigenic cytokines and synergizes with paclitaxel to ...
Susan E. Logue, Eoghan P. McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M. Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C. Madden, Brian Leuzzi, Joanna Obacz, Qingping Zeng, John B. Patterson, Richard Jäger, Adrienne M. Gorman, Afshin Samali   +18 more
doaj   +1 more source

BCL-2 family members and the mitochondria in apoptosis.

Genes & Development, 1999
A variety of physiological death signals, as well as pathological cellular insults, trigger the genetically programmed pathway of apoptosis (Vaux and Korsmeyer 1999). Apoptosis manifests in two major execution programs downstream of the death signal: the
A. Gross, J. McDonnell, S. Korsmeyer
semanticscholar   +1 more source

SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis

, 2017
Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis ...
Domanskyi, Sergii, Libert, Sergiy, Nicholatos, Justin W., Privman, Vladimir, Schilling, Joshua E.   +4 more
core   +1 more source

Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]

, 2001
Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Chen, Youhai, El-Deiry, Wafik S., Göke, Alexandra, Göke, Burkhard, Göke, Rüdiger   +4 more
core   +1 more source

miR-15 and miR-16 induce apoptosis by targeting BCL2.

Proceedings of the National Academy of Sciences of the United States of America, 2005
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated
A. Cimmino, G. Calin, M. Fabbri, M. Iorio, M. Ferracin, M. Shimizu, Sylwia E. Wojcik, R. Aqeilan, S. Zupo, M. Dono, L. Rassenti, H. Alder, S. Volinia, Chang-gong Liu, T. Kipps, M. Negrini, C. Croce   +16 more
semanticscholar   +1 more source

Confocal Raman data analysis enables identifying apoptosis of MCF-7 cells caused by anticancer drug paclitaxel [PDF]

, 2013
Confocal Raman microscopy is a noninvasive, label-free imaging technique used to study apoptosis of live MCF-7 cells. The images are based on Raman spectra of cells components, and their apoptosis is monitored through diffusion of cytochrome c in ...
Attila-Gergely Vegh, Csilla Gergely, Elodie Middendorp, Frederic Cuisinier, Hamideh Salehi, Ivan Panayotov, Pierre-Yves Collart Dutilleul, Sathish Ramakrishnan   +7 more
core   +1 more source

Apoptosis in the lungs of pigs infected with porcine reproductive and respiratory syndrome virus and associations with the production of apoptogenic cytokines [PDF]

, 2003
International audienceApoptosis was studied in the lungs of pigs during an infection with a European strain of porcine reproductive and respiratory syndrome virus (PRRSV) and it was examined if cytokines were involved in the induction of apoptosis ...
Labarque, Geoffrey, Nauwynck, Hans, Pensaert, Maurice, Van Gucht, Steven, Van Reeth, Kristien   +4 more
core   +3 more sources

Photoablation at single cell resolution and its application in the Drosophila epidermis and peripheral nervous system

Frontiers in Physiology, 2023
Tissues contain diverse cell populations that, together, make up physiologically functional units. A remarkable example is the animal epidermis, where neuronal and non-neuronal cells intermingle to allow somatosensory perception.
Federica Mangione, Rocco D’Antuono, Nicolas Tapon   +2 more
doaj   +1 more source

Bid participates in genotoxic drug-induced apoptosis of HeLa cells and is essential for death receptor ligands' apoptotic and synergistic effects [PDF]

, 2008
Background: The BH3-only protein Bid is an important component of death receptor-mediated caspase activation. Bid is cleaved by caspase-8 or -10 into t-Bid, which translocates to mitochondria and triggers the release of caspase-activating factors.
Anguissola, Sergio, Concannon, Caoimhin G., Kögel, Donat, Köhler, Barbara, Prehn, Jochen H. M., Rehm, Markus   +5 more
core   +1 more source

Apoptosis

Bitlis Eren Üniversitesi Fen Bilimleri Dergisi, 2014
Apoptozis ya da programlı hücre ölümü sağlıklı çok hücreli organizmada meydana gelen fizyolojik bir olgudur. Bu olgu, temel tıp bilimlerinde anlaşılması güç birçok olayın açıklanmasında kullanılmıştır. Hücre ölümüne sebep olan temel faktörlerden birinin serbest radikaller olduğu bilinmektedir.
MİS, Leyla, YELTEKİN, Aslı Çilingir
openaire   +3 more sources