Results 61 to 70 of about 2,974,203 (387)
The BH3-mimetic ABT-737 effectively kills acute myeloid leukemia initiating cells
Leukemia Research Reports, 2014 The anti-apoptotic proteins Bcl-XL and Bcl-2 are abundantly expressed in hematopoietic stem cells and/or progenitor cells. Furthermore, leukemic cells expressing these proteins are enriched in minimal residual disease cell populations.
Denis V. Baev +3 more
doaj +1 more source
A caspase-3 'death-switch' in colorectal cancer cells for induced and synchronous tumor apoptosis in vitro and in vivo facilitates the development of minimally invasive cell death biomarkers [PDF]
, 2013 Novel anticancer drugs targeting key apoptosis regulators have been developed and are undergoing clinical trials. Pharmacodynamic biomarkers to define the optimum dose of drug that provokes tumor apoptosis are in demand; acquisition of longitudinal tumor
Brown, G. +14 more
core +2 more sources
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway
eLife, 2013 Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same ...
Ainhoa Pérez-Garijo +2 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2022 Background Medulloblastoma is the most common malignant pediatric brain tumor and group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis.
Meng Li +6 more
doaj +1 more source
The Journal of Pathology, 1999 The dogma that antineoplastic treatments kill tumour cells by damaging essential biological functions has been countered by the notion that treatment itself initiates a programmed cellular response. This response often produces the morphological features of apoptosis and is determined by a network of proliferation and survival genes, some of which are ...
Scott W. Lowe, Clemens A. Schmitt
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Cell Death and DiseaseSmac mimetic compounds (SMCs) are small molecule drugs that sensitize cancer cells to TNF-α-induced cell death and have multiple immunostimulatory effects through alterations in NF-κB signaling.
Kyle Malone +5 more
doaj +1 more source
Biomarker Research, 2020 Background Clinically relevant methods are not available that prioritize and validate potential therapeutic targets for individual tumors, from the vast amount of tumor descriptive expression data. Methods We established inducible transgene expression in
Wen-Hsin Liu +10 more
doaj +1 more source
Accumulation of tissue factor in endothelial cells induces cell apoptosis, mediated through p38 and p53 activation [PDF]
, 2015 We previously reported that high levels of tissue factor (TF) can induce cellular apoptosis in endothelial. In this study, TF-mediated mechanisms of induction of apoptosis were explored.
Collier, Mary E. W. +3 more
core +1 more source
APOPTOSIS. THE ROLE OF APOPTOSIS IN CANCERS
, 2023 Apoptosis is a complex mechanism that is involved at any stage during organism development or in cellular damage. It is triggered by specific external and internal factors such as ultraviolet radiation, hypoxia, growth factors, viruses, and bacteria, which activate the two main pathways: the extrinsic pathway, also known as the death receptor pathway ...
Orlov Alina, Dumitraș Grigore
openaire +2 more sources